Abstract
The kidney has been traditionally considered as one of the two primary target organs in gout (1), but long-term follow-up studies have failed to show a deleterious effect of gout on renal function (2). However, it has been reported that some patients with uncomplicated gout have developed rapidly progressive renal failure (2). Moreover, several families have been described with hyperuricemia or gout, usually appearing at an early age and often in both sexes, associated with progressive renal failure (3–15). The pathogenesis of this syndrome has not been clearly elucidated. We describe eight patients in two families who had hyperuricemia or gout, renal insufficiency, and bilaterally small kidney size.
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Puig, J.G., Carús, M.E.M., Mateos, F.A., Picazo, M.L., Jiménez, M.L., Vázquez, J.O. (1991). Familial Nephropathy and Gout: Which Comes First?. In: Harkness, R.A., Elion, G.B., Zöllner, N. (eds) Purine and Pyrimidine Metabolism in Man VII. Advances in Experimental Medicine and Biology, vol 309A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2638-8_44
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DOI: https://doi.org/10.1007/978-1-4899-2638-8_44
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