Abstract
The uricosuric substance benzbromarone initially was reported to be debrominated to bromobenzarone and benzarone (Yü 1976). Recently hydroxilation was shown to be the primary metabolic pathway (Walter-Sack et al 1987). In addition, in a few individuals pharmacokinetic studies showed evidence for a deficient benzbromarone elimination from plasma, characterized by a longer persistance of benzbromarone in the plasma (Walter-Sack et al 1988; Walter-Sack et al 1990a), which is likely to be a familial disorder (Zöllner et al 1990).
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Gresser, U., Empl, H., Kamilli, I., Zöllner, N. (1991). Pharmacokinetics of Benzbromarone: Evidence for a Biliary-Intestinal-Biliary Recirculation. In: Harkness, R.A., Elion, G.B., Zöllner, N. (eds) Purine and Pyrimidine Metabolism in Man VII. Advances in Experimental Medicine and Biology, vol 309A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2638-8_33
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DOI: https://doi.org/10.1007/978-1-4899-2638-8_33
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