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Candida Blastospore Adhesion, Association, and Invasion of the Gastrointestinal Tract of Vertebrates

  • Chapter
The Fungal Spore and Disease Initiation in Plants and Animals

Abstract

Survival, implantation, and dissemination from the alimentary tract by Candida species, and Candida albicans in particular, may play an important role in human and animal health. Recurrent vaginitis and systemic candidosis, for instance, have both been linked to colonization of the gastrointestinal (GI) tract by C. albicans (Krause et al., 1969; Stone, 1974; Miles et al., 1977; Myerowitz et al., 1977; Nystatin Multicenter Study Group, 1986), and the alimentary tract is now regarded by some as the proximate source of infection in these and other types of infections caused by Candida species (Odds, 1988). The “overgrowth” of C. albicans in the GI tract, and its subsequent passage through the gut mucosa into the host bloodstream is thus believed to be the primary mechanism leading to systemic candidosis in severely compromised patients (Stone et al., 1974). This type of “autoinoculation” or “self-inoculation” appears to be particularly prevalent among individuals with acute leukemia (Myerowitz et al., 1977). Similarly, colonization of the GI tract by C. albicans and other Candida species may also lead to involvement in a number of other disease syndromes that include esophageal, gastric, and intestinal thrush, gastric and intestinal ulceration, GI bleeding, diarrhea, peritonitis, perianal itch, napkin dermatitis, chronic “irritable bowel” syndrome, autobrewery syndrome, and growth depression in food-producing animals (Odds, 1988; Rippon, 1988).

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  1. The Upjohn Company, Kalamazoo, Michigan, 49001, USA

    Michael J. Kennedy

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  1. The University of Texas at Austin, Austin, Texas, USA

    Garry T. Cole

  2. New York State Agricultural Experiment Station, Cornell University, Geneva, New York, USA

    Harvey C. Hoch

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Kennedy, M.J. (1991). Candida Blastospore Adhesion, Association, and Invasion of the Gastrointestinal Tract of Vertebrates. In: Cole, G.T., Hoch, H.C. (eds) The Fungal Spore and Disease Initiation in Plants and Animals. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2635-7_7

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