Abstract
All organisms have evolved to succeed in a particular niche, and fungi pathogenic to man are no exception. Many colonize healthy hosts at low levels as commensals. When the host becomes physiologically or immunologically compromised, or in some cases, even when the host exhibits no obvious predisposing conditions, these fungi multiply and penetrate tissue, causing infection and, in an ever-increasing number of cases, death. Our primary interest is the capacity of these fungi to cause disease, and our ultimate goals are to control their growth and invasiveness, and to irradicate them in infected hosts. The application of new technologies of molecular biology will, without doubt, play a crucial role in this endeavor since it will be through them that we ultimately elucidate the genes, regulatory pathways, and gene products which combine to make these fungi such successful pathogens. In this review, the discussion will focus first upon the basic biology of one of the more prominent of these fungi, Candida albicans. The progress which has been made as well as the potential which now exists for applying molecular genetic techniques to the pathogenesis and epidemiology of this opportunistic pathogen will be reviewed.
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References
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© 1991 Springer Science+Business Media New York
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Soll, D.R. (1991). Current Status of the Molecular Basis of Candida Pathogenicity. In: Cole, G.T., Hoch, H.C. (eds) The Fungal Spore and Disease Initiation in Plants and Animals. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2635-7_23
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