Skip to main content
SpringerLink
Log in

Anti-Nutritive Effects of Dietary Tin

  • Chapter
Nutritional and Toxicological Consequences of Food Processing

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 289))

Abstract

Tin is usually present in foods at levels of less than 4 μg/g. Higher levels may be found in some processed foods due to the addition of tin-based preservatives and stabilizers or to corrosion and leaching of the metal from unlacquered cans or from tin foils used in packaging. Estimates of dietary intake range from about 0.2 to > 5 mg Sn/day. Diets including a high proportion of canned vegetables and fish could supply > 30 mg Sn/day. Although intakes from dietary sources are generally considered to be harmless, a variety of adverse effects of tin have been reported, including effects on serum and bone alkaline phosphatase, lactic dehydrogenase, heme oxygenese, and 5-aminolevulinic acid dehydratase. Perturbations in glutathione metabolism have been reported, as have adverse effects on metabolism of essential trace minerals such as copper, zinc, and iron. Specific effects on calcium content of bone, serum, and kidney have also been described. Reported effects vary with the chemical form, dose of tin, and route and frequency of administration. Effects of tin in animal systems and on essential trace mineral absorption and excretion in human volunteers are reviewed. A summary of recent investigations on dietary tin-copper interactions and effects of tin on rat hepatocellular antioxidant protection are also presented.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Allen, K. G. D., Arthur, J. R., Movica, P. C., Nichol, F., and Hills, C. F. (1988). Copper deficiency and tissue glutathlonine concentration in the rat. Proc. Soc. Exp. Blol. Med. 187, 38–43.

    Article  CAS  Google Scholar 

  • Alvarez, G. H. and Capar, S. G. (1987). Determination of tin in foods by hydride generation atomic absorption spectrometry. Anal. Chem. 59(3), 530–533.

    Article  CAS  Google Scholar 

  • American Institute of Nutrition. (1977). Report of the AIN ad hoc Committee on Standards for Nutritional Studies. J. Nutr. 107, 1340–1348.

    Google Scholar 

  • American Institute of Nutrition. (1980). Second report of the ad hoc Committee on Standards for Nutritional Studies. J. Nutr. 110, 1726.

    Google Scholar 

  • Athar, M., Hasan, S. K., and Srivastava, R.C. (1987). Role of glutathione metabolzing enoymes in nickel-mediated induction of hepatic glutathione. Res. Commun. Chem. Pathol. Pharmacol. 57, 421–424.

    CAS  Google Scholar 

  • Barker, W. H., Jr. and Runte, V. (1972). Tomato juice-associated gastroenteritis, Washington and Oregon 1969. Am. J. Epidemiol. 96, 219–226.

    Google Scholar 

  • Barnes, J. M. and Stoner, H. B. (1959). The toxicology of tin compounds. Pharmacol. Rev. 11, 211–231.

    CAS  Google Scholar 

  • Benoy, C. J., Hooper, P. A., and Schneider, R. (1971). The toxicity of tin in canned fruit juices and solid foods. Food Cosmet. Toxicol. 9, 645–656.

    Article  CAS  Google Scholar 

  • Boyer, I. J. (1989). Toxicity of dibutyl tin, tributyl tin and other organotin compounds to humans and to experimental animals. Toxicol. 55, 253–298.

    Article  CAS  Google Scholar 

  • Burba, J. V. (1983). Inhibition of hepatic azo-reductase and aromatic hydrozylase by radiopharmaceuticals containing tin. Toxicol. Lett. 18, 269–272.

    Article  CAS  Google Scholar 

  • Capar, S.G. and Boyer, K.W. (1980). Multielement analysis of foods stored in their opened cans. J. Food Saf. 2, 105–118.

    Article  CAS  Google Scholar 

  • Chiba, H., Ogihara, K., and Kikuchi, N. (1980). Effect of tin on porphyrin biosynthesis. Arch. Toxicol. 45, 189–195.

    Article  CAS  Google Scholar 

  • Davis, G. K. and Mertz, W. (1987). Copper. In: “Trace Elements in Human and Animal Nutrition”, W. Mertz, ed., Academic Press, New York, 5th edition, pp. 301–364.

    Google Scholar 

  • DeGroot, A. P. (1973). Subacute toxicity of inorganic tin as influenced by dietary levels of iron and copper. Food Cosmet. Toxicol. 11, 955–962.

    Article  CAS  Google Scholar 

  • DeGroot, A. P., Feron, V. J., and Til, H. P. (1973). Short-term toxicity studies on some salts and oxides of tin in rats. Food Cosmet. Toxicol. 11, 11–30.

    Article  Google Scholar 

  • DeRosa, G., Keen, C. L., Leach, R. M., and Hurley, L.S. (1980). Regulation of Superoxide dismutase activity by dietary manganese. J. Nutr. 110: 895–804.

    Google Scholar 

  • Dwivedi, R. S., Kaur, G., Srivastava, R. C., and Krishna Murti, C. R. (1984). Lipid peroxldation in tin-intoxicated partially-hepatectomized rats. Bull. Environ. Contain, Toxicol. 33, 200–209.

    Article  CAS  Google Scholar 

  • Fritech, P., DeSalnt-Blanquat, G., and Derache, R. (1977). Effect of various dietary components on absorption and tissue distribution of orally administered inorganic tin in rats. Food Cosmet. Toxicol. 15, 147–149.

    Article  Google Scholar 

  • Furchner, J. E. and Drake, G. A. (1976). Comparative metabolism of radionuclides in mammals-XI. Retention of 113-Sn in the mouse, rat, monkey, and dog. Health Phys. 21, 219–224.

    Article  Google Scholar 

  • Greger, J. L. and Baier, M. (1981). Tin and iron content of canned and bottled foods. J. Food Sci. 46, 1751–1753 and 1765.

    Article  CAS  Google Scholar 

  • Greger, J. L. and Johnson, M. A. (1981). Effect of dietary tin on zinc, copper and iron utilization by rats. Food Cosmet. Toxicol. 19, 163–166.

    Article  CAS  Google Scholar 

  • Greger, J. L. and Lane, H. W. (1987). The toxicology of dietary tin, aluminum, and selenium. In: “Nutritional Toxicology”, J.N. Hathcock, ed., Academic Press, New York, Vol. 2, pp. 223–247.

    Google Scholar 

  • Greger, J. L., Smith, S. A., Johnson, H. A., and Baler, M. J. (1982). Effects of dietary tin and aluminum on selenium utilization by adult males. Biol. Trace Elem. Res. 2, 269–278.

    Article  Google Scholar 

  • Griffith, O. W. (1980). Determination of glutathione and glutathione dlsulflde using glutathione reductase and 2-vinylpyridine. Anal. Biochem. 106, 207–212.

    Article  CAS  Google Scholar 

  • Hiles, R. A. (1974). Absorption, distribution, and excretion of inorganic tin in rats. Toxicol. Appl. Pharmacol. 27, 366–379.

    Article  CAS  Google Scholar 

  • Jenkinson, S. G., Lawrence, R.A., Burk, R. F., and Williams, D.M. (1982). Effects of copper deficiency on the activity of the selenoenoyme glutathione peroxldase and on the excretion and tissue retention of 75SeO3 2−. J. Nutr. 112: 197–204.

    CAS  Google Scholar 

  • Johnson, M. A., Baler, M. J., and Greger, J. L. (1982). Effects of dietary tin on zinc, copper, iron, manganese, and magnesium metabolism in adult males. Am. J. Clin. Nutr. 35, 1332–1338.

    CAS  Google Scholar 

  • Johnson, M. A. and Greger, J. L. (1982). Effects of dietary tin on tin and calcium metabolism in adult males. Am. J. Clin. Nutr. 35, 655–660.

    CAS  Google Scholar 

  • Johnson, M. A. and Greger, J. L. (1984). Absorption, distribution and endogenous excretion of zinc by rats fed various dietary levels of inorganic tin and zinc. J. Nutr. 114, 1843–1852.

    CAS  Google Scholar 

  • Johnson, M. A. and Greger, J. L. (1985). Tin, copper, iron and calcium metabolism in rats fed various levels of inorganic tin and zinc. J. Nutr. 115, 615–624.

    CAS  Google Scholar 

  • Kappas, A. and Maines, M. D. (1976). Tin: A potent lnducer of heme oxygenase in kidney. Science 192, 60–62.

    Article  CAS  Google Scholar 

  • Levine, W.G. (1982). Glutathione, lipid peroxidation and regulation of cytochrome P-450 activity. Life Sci. 31, 779–784.

    Article  CAS  Google Scholar 

  • Magos, L. (1986). Tin. In: “Handbook on the Toxicology of Metals”, L. Friberg, G. F. Nordberg, and V. B. Vouk, eds., Elsevier, New York, 2nd ed., Vol. II, pp. 568–593.

    Google Scholar 

  • Nielsen, F. H. (1986). Other Elements: Sb, Ba, B, Br, Cs, Ge, Rb, Ag, Sr, Sn, Ti, Zr, Be, Bi, Ga, Au, In, Nb, Sc, Te, Tl, W. In: “Trace Elements in Human and Animal Nutrition”, W. Mertz, ed., Academic Press, New York, 5th ed., Vol. 2, pp. 415–463.

    Chapter  Google Scholar 

  • Paglia, D. E. and Valentine, W. M. (1967). Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J. Lab. Clin. Med. 70, 158–169.

    CAS  Google Scholar 

  • Paynter, D. I., Moir, R. J., and Underwood, E. J. (1979). Changes in activity of Cu-Zn Superoxide dismutase enoyme in tissues of the rat with changes in dietary copper. J. Hutr. 109, 1570–1576.

    CAS  Google Scholar 

  • Prohaska, J.R., Downing, S. W., and Lukasewycz, O. A. (1983). Chronic dietary deficiency alters biochemical and morphological properties of mouse lymphoid tissue. J. Nutr. 113: 1583–1590.

    CAS  Google Scholar 

  • Rader, J. I., Hight, S. C., and Capar, S. G. (1990). Effects of dietary sugars and cellulose on tissue minerals in weanling rats fed purified diets of adequate or marginal nutrient content. J. Trace Elem. Exptl. Med., in press

    Google Scholar 

  • Rader, J. I., Volnik, K. A., Gaston, C. M., Celesk, E. M., Peeler, J. T., Fox, M. R. S., and Frlcke, F. L. (1984). Trace element studies in weanling rats: Maternal diets and baseline tissue mineral values. J. Nutr. 114, 1946–1954.

    CAS  Google Scholar 

  • Rader, J. I., Wolnik, K. A., Gaston, C. M., Fricke, F. L., and Fox, M. R, S. (1986). Purified reference diets for weanling rats: Effects of biotin and cellulose. J. Nutr. 116, 1777–1788.

    CAS  Google Scholar 

  • Rotruck, J. T., Pope, A. L., Ganther, H.E., Hafeman, D. G., and Hoekstra, W. G. (1973). Selenium: Biochemical role as a component of glutathione peroxidase. Science 179, 588–590.

    Article  CAS  Google Scholar 

  • Schosinsky, K. H., Lehmann, H. P., and Beeler, M. F. (1974). Measurement of ceruloplasmin from its oxidase activity in serum by use of o-dianisidine dlhydrochloride. Clin. Chea. 20, 1556–1563.

    CAS  Google Scholar 

  • Shukla, G. S., Srlvasta, R. S., and Chandra, S. V. (1987). Glutathione metabolism in liver, kidney, and testis of rats exposed to cadmium. Ind. Health 25, 139–146.

    Article  CAS  Google Scholar 

  • Stacey, N. H. and Klaassen, D. C. (1981). Comparison of the effects of metals on cellular injury and lipid peroxidation in isolated rat hepatocytes. Toxicol. Environ. Health 7, 139–147.

    Article  CAS  Google Scholar 

  • Valberg, L. S., Flanagan, P. R., and Chamberlain, M. J. (1984), Effects of iron, tin, and copper on zinc absorption in humans. Am. J. Clin. Nutr. 40, 536–541.

    CAS  Google Scholar 

  • Warburton, S-, Udler, W., Ewert, R. M., and Haynes, W. S. (1962). Outbreak of foodborne illness attributed to tin. Public Health Rep. 77, 798–800.

    Article  CAS  Google Scholar 

  • World Health Organization United Nations Environmental Program. (1980). Tin and Organotin Compounds, Environmental and Health Criteria, 15. World Health Organization, Geneva.

    Google Scholar 

  • Yamaguchi, M., Saito, R., and Okada, S. (1980). Dose-effect of inorganic tin on biochemical indices in rats. Toxicol. 16, 267–273.

    Article  CAS  Google Scholar 

  • Yamaguchi, M., Sugli, K., and Okada, S. (1981). Inorganic tin in the diet affects the femur in rats. Toxicol. Lett. 9, 207–209.

    Article  CAS  Google Scholar 

  • Yamaguchi, M., Sugli, K., and Okada, S. (1982). Tin decreases femoral calcium Independently of calcium homeostasis in rats. Toxicol. Lett. 10, 7–10.

    Article  CAS  Google Scholar 

  • Yamamoto, T., Yamaguchi, M., and Sato, H. (1976). Accumulation of calcium in kidney and decrease in calcium in serum of rats treated with tin chloride, J. Toxicol. Environ. Health 1, 749–756.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Nutrition, Food and Drug Administration, 200 C Street, S.W., Washington, DC, 20204, USA

    Jeanne I. Rader

Authors
  1. Jeanne I. Rader
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. U.S. Department of Agriculture, Albany, California, USA

    Mendel Friedman

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Springer Science+Business Media New York

About this chapter

Cite this chapter

Rader, J.I. (1991). Anti-Nutritive Effects of Dietary Tin. In: Friedman, M. (eds) Nutritional and Toxicological Consequences of Food Processing. Advances in Experimental Medicine and Biology, vol 289. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2626-5_34

Download citation

  • DOI: https://doi.org/10.1007/978-1-4899-2626-5_34

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-2628-9

  • Online ISBN: 978-1-4899-2626-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation