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Behavior in Autoimmune Mice

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International Perspectives on Self-Regulation and Health

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Abstract

Several lines of research suggest that the nervous system and the immune system interact at several levels to constitute an integrated mechanism of defense. For example, recent studies document that lymphoid tissue is innervated by the sympathetic nervous system (Feiten, Feiten, Bellinger, Carlson, Ackerman, Madden, Olschowka, & Livnat, 1987), and lesions or electrical stimulation of hypothalamic structures alter immunologic reactivity (Roszman, Jackson, Cross, Titus, Markesbery, & Brooks, 1985; Stein, Schleifer, & Keller, 1981). Conversely, activation of the immune system by injecting animals with antigen results in an increase in the firing rate of neurons within the ventromedial hypothalamus (Besedovsky, Sorkin, Keller, Felix, & Haas, 1977). The exogenous alteration of blood levels of a variety of hormones also influences immune responses, and, conversely, activation of the immune system elicits endocrine responses such as changes in adrenocortical steroid and catecholamine levels (Besedovsky, del Rey, Sorkin, DaPrada, Burri, & Honegger, 1983; Besedovsky, Sorkin, Keller, & Muller, 1975; Livnat, Feiten, Carlson, Bellinger, & Feiten, 1985; Shek & Sabiston, 1983). In this chapter, I propose to discuss some of the evidence for a similar reciprocal relationship between behavior and immune function based, presumably, on the existence of neural and endocrine pathways that provide a link between these adaptive systems.

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Authors and Affiliations

  1. Department of Psychiatry, University of Rochester School of Medicine and Dentistry, Rochester, New York, 14642, USA

    Robert Ader

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  1. Robert Ader
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Editors and Affiliations

  1. Department of Psychology, University of Hawaii at Manoa, Honolulu, Hawaii, 96822, USA

    John G. Carlson

  2. Behavioral Institute of Atlanta, Atlanta, Georgia, 30342, USA

    A. Ronald Seifert

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Ader, R. (1991). Behavior in Autoimmune Mice. In: Carlson, J.G., Seifert, A.R. (eds) International Perspectives on Self-Regulation and Health. The Springer Series in Behavioral Psychophysiology and Medicine. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2596-1_9

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  • DOI: https://doi.org/10.1007/978-1-4899-2596-1_9

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