Skip to main content

Interactions between Zinc, Vitamins A and D and Hormones in the Regulation of Growth

  • Chapter
Nutrient Regulation during Pregnancy, Lactation, and Infant Growth

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 352))

Abstract

The essentiality of zinc for normal growth of young mammals was one of the first deficiency characteristics to be recorded. The decline in growth is severe and rapid and is accompanied by a simultaneous reduction in appetite. Although a portion of the decline in growth can be attributed to diminished voluntary food intake, pair-feeding and force-feeding experiments have shown a decline in food efficiency independent of the appetite phenomenon (Chesters and Quarterman, 1970). Moreover, comprehensive studies by Lucille Hurley and colleagues (1980) have shown that zinc deprivation during gestation results in a large number of teratogenic outcomes. Thus, the clinical manifestations of zinc deficiency reflect a wide range of metabolic roles for this ion.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Abbasi, A. A., Prasad, A. S., Ortega, J., Congco, E., and Oberleas, D., 1976, Gonadal function abnormalities in sickle cell anemia: studies in adult male patients, Ann. Intern. Med. 85:601.

    Article  PubMed  CAS  Google Scholar 

  • Bedo, G., Santisteban, P., Aranda, A., 1989, Retinoic acid regulates growth hormone gene expression, Nature 339:231.

    Article  PubMed  CAS  Google Scholar 

  • Caldwell, D. F., Oberleas, D., Clancy, J. J., and Prasad, A. S., 1970, Behavioural impairment in adult rats following acute zinc deficiency, Proc. Soc. Exp. Biol. Med. 133:1417.

    Article  PubMed  CAS  Google Scholar 

  • Caldwell, D. F., Oberleas, D., and Prasad, A. S., 1973, Reproductive performance of chronically mildly zinc deficient rats and the effect on behavior of their offspring, Nutr. Rep. Int. 7:309.

    CAS  Google Scholar 

  • Chesters, J. K., 1978, Biochemical functions of zinc in animals, Wld. Rev. Nutr. Diet. 32:135.

    CAS  Google Scholar 

  • Chesters, J. K., and Quarterman, J., 1970, Effects of zinc deficiency on food intake and feeding patterns of rats, Br. J. Nutr. 24:1061.

    Article  PubMed  CAS  Google Scholar 

  • Colvard, D. S., and Wilson, E. M., 1984, Zinc potentiation of androgen receptor binding to nuclei in vitro, Biochemistry 23:3471.

    Article  PubMed  CAS  Google Scholar 

  • DePasquale-Jardieu, P., and Fraker, P. J., 1980, Further characterization of the role of corticosterone in the loss of humoral immunity in zinc-deficient A/J mice as determined by adrenalectomy, J. Immunol. 124:2650.

    PubMed  CAS  Google Scholar 

  • Eklund, A., Agren, G., Nordgren, H. and Stenram, U., 1974, Effects on urine volume and composition of rats fed protein concentrates from rapeseed and sunflower seed, with blood, post-mortem and histo-pathological observations, J. Sci. Fd. Agric. 25:343.

    Article  CAS  Google Scholar 

  • Gordon, E. F. Bond, J. T., and Denny, M. R., 1982, Zinc deficiency and behavior: a developmental perspective, Physiol. Behav. 28:893.

    Article  PubMed  CAS  Google Scholar 

  • Halas, E. S., Heinrich, M. D., and Sandstead, H. H., 1979, Long term memory deficits in adult rats due to postnatal malnutrition, Physiol. Behav. 22:991.

    Article  PubMed  CAS  Google Scholar 

  • Herdegen, T., Walker, T., Leah, J. D., Bravo, R., and Zimmerman, M., 1990, The KROX-24 protein, a new transcription regulating factor: expression in the rat central nervous system following afferent somatosensory stimulation, Neuroscience Lttrs. 120:21.

    Article  CAS  Google Scholar 

  • Hesketh, J. E., 1982, Effects of dietary zinc deficiency on Leydig cell ultrastructure in the boar, J. Comp. Path. 92:239.

    Article  PubMed  CAS  Google Scholar 

  • Hurley, L., 1980, “Developmental Nutrition,” Prentice-Hall, Englewood Cliffs, NJ.

    Google Scholar 

  • Johnson, P. F., and McKnight, S. L., 1989, Eukaryotic transcriptional regulatory proteins, Annu. Rev. Biochem. 58:799.

    Article  PubMed  CAS  Google Scholar 

  • Kratzer, F. H., Vohra, P., Allred, J. B., and Davis, P. N., 1958, Effect of zinc upon growth and incidence of perosis in turkey poults, Proc. Soc. Exp. Biol. Med. 98:205.

    Article  PubMed  CAS  Google Scholar 

  • Laudet, V., and Stehelin, D., 1992, Flexible friends, Current Biol 2:293.

    Article  CAS  Google Scholar 

  • Martial, J. A., Seeburg, P. H., Guenzi, D., 1977, Regulation of growth hormone gene expression: syngeristic effects of thyroid and glucocorticoid hormones, Proc. Natl. head. Sci. USA 74:4293.

    Article  CAS  Google Scholar 

  • McClain, C. J., Gavaler, J. S., and Van Thiel, D. H., 1984, Hypogonadism in the zinc-deficient rat: localization of the functional abnormalities, J. Lab. Clin. Med. 104:1007.

    PubMed  CAS  Google Scholar 

  • Miller, J., McLachlan, A. D. and Klug, A., 1985, Repetitive zinc-binding domains in the protein transcription factor IIIA from Xenopus oocytes, EMBO J. 4:1609.

    PubMed  CAS  Google Scholar 

  • Miller, J. K., and Miller, W. J., 1960, Development of zinc deficiency in Holstein calves fed a purified diet, J. Dairy Sci. 43:1854.

    Article  CAS  Google Scholar 

  • Miller, J. K., and Miller, W. J., 1962, Experimental zinc deficiency and recovery of calves, J. Nutr. 76:467.

    PubMed  CAS  Google Scholar 

  • Morley, J. E., Gordon, J., and Hershman, J. M., 1980, Zinc deficiency, chronic starvation, and hypothalamic-pituitary-thyroid function, Am. J. Clin. Nutr. 33:1767.

    PubMed  CAS  Google Scholar 

  • Nikolaev, E., Kaminska, B., Tischmeyer, W., Matthies, H., and Kaczmarek, L., 1992, Induction of expression of genes encoding transcriptional factors in the rat brain elicited by behavioral training, Brain Res. Bull. 28:479.

    Article  PubMed  CAS  Google Scholar 

  • Norrdin, R. W., Krook, L., Pond, W. G., and Walker, E. F., 1973, Experimental zinc deficiency in weanling pigs on high and low calcium diets, Cornell Vet.

    Google Scholar 

  • O’Dell, B. L., Newberne, P. M., and Savage, J. E., 1958, Significance of dietary zinc for the growing chicken, J. Nutr. 65:503.

    PubMed  Google Scholar 

  • Podlecki, D. A., Smith, R. M., Kao, M., Tsai, P., Huecksteadt, T., Brandenburg, D., Lasher, R. S., Jarett, L., and Olefsky, J. M., 1987, Nuclear translocation of the insulin receptor, J. Biol. Chem. 262:3362.

    PubMed  CAS  Google Scholar 

  • Prasad, A. S., Miale, A., Jr., Farid, Z., Sandstead, H. H., and Schulert, A. R., 1963b, Zinc metabolism in patients with syndrome of iron deficiency anemia, hepatosplenomegaly, dwarfism and hypogonadism, Lab. Clin. Med. 61:537.

    CAS  Google Scholar 

  • Prasad, A. S., Miale, A., Jr., Farid, Z., Sandstead, H. H., Schulert, A. R., and Darby, W. J., 1963a, Biochemical studies on dwarfism, hypogonadism and anemia, Arch. Intern. Med. 111:407.

    Article  PubMed  CAS  Google Scholar 

  • Predki, P. F. and Sarkar, B., 1992, Effect of replacement of “zinc finger” zinc on estrogen receptor DNA interactions, J. Biol. Chem. 267:5842.

    PubMed  CAS  Google Scholar 

  • Ronaghy, H. A., and Halsted, J. A., 1975, Zinc deficiency occurring in females. Report of two cases, Am. J. Clin. Nutr. 28:831.

    PubMed  CAS  Google Scholar 

  • Root, A. W., Duckett, G., Sweetland, M., and Reiter, E. O., 1979, Effects of zinc deficiency upon pituitary function in sexually mature and immature male rats, J. Nutr. 109:958.

    PubMed  CAS  Google Scholar 

  • Roth, H. P., and Kirchgessner, M., 1974, Z. Tierphysiol. Tierernaehr. Futtermittelkd. 32:296, as reported by Hambidge, K. M., Casey, C. E., and Krebs, N. F., 1986, Zinc, in “Trace Elements in Human and Animal Nutrition, 5th Ed.,” W. Mertz, ed., Academic Press, Orlando, FL, USA.

    Google Scholar 

  • Sabbah, M., Redeuilh, G., Secco, C. and Baulieu, E-E., 1987, The binding activity of estrogen receptor to DNA and heat shock protein (Mr 90,000) is dependent on receptor-bound metal, J. Biol. Chem. 262:8631.

    PubMed  CAS  Google Scholar 

  • Sandstead, H. H., Prasad, A. S., Farid, Z., et al, 1967, Human zinc deficiency, endocrine manifestations, and response to treatment, Am. J. Clin. Nutr. 20:422.

    PubMed  CAS  Google Scholar 

  • Styrud, J., Dahlstrom, V. E., and Eriksson, U. J., 1986, Induction of skeletal malformations in the offspring of rats fed a zinc deficient diet, Uppsala J. Med. Sci. 91:29.

    Article  CAS  Google Scholar 

  • Sunderman, F.W., Jr., and Barber, A.M., 1988, Finger-loops, oncogenes, and metals, Ann. Clin. Lab. Sci. 18:267.

    PubMed  CAS  Google Scholar 

  • Thiesen, H-J., 1990, Multiple genes encoding zinc finger domains are expressed in human T cells, The New Biologist 2:363.

    PubMed  CAS  Google Scholar 

  • Vallee, B. L., and Auld, D. S., 1990, Zinc coordination, function and structure of zinc enzymes and other proteins, Biochemistry 29:5647.

    Article  PubMed  CAS  Google Scholar 

  • Williams, R. J. P., 1989, An introduction to the biochemistry of zinc, in “Zinc in Human Biology,” C. F. Mills, ed., Springer-Verlag, London.

    Google Scholar 

  • Yamaguchi, M., and Oishi, H., 1989, Effect of 1,25-dihydroxy vitamin D3 on bone metabolism in tissue culture: enhancement of the steroid effect by zinc, Biochem. Pharmacol. 38:3543.

    Article  Google Scholar 

  • Yamaguchi, M., Oishi, H., and Suketa, Y., 1987, Stimulatory effect of zinc on bone formation in tissue culture, Biochem. Pharmacol. 36:4007.

    Article  PubMed  CAS  Google Scholar 

  • Yamaguchi, M., and Yamaguchi, R., 1986, Action of zinc on bone metabolism in rats: increases in alkaline phosphatase activity and DNA content, Biochem. Pharmacol. 35:773.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1994 Springer Science+Business Media New York

About this chapter

Cite this chapter

Bunce, G.E. (1994). Interactions between Zinc, Vitamins A and D and Hormones in the Regulation of Growth. In: Allen, L., King, J., Lönnerdal, B. (eds) Nutrient Regulation during Pregnancy, Lactation, and Infant Growth. Advances in Experimental Medicine and Biology, vol 352. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2575-6_23

Download citation

  • DOI: https://doi.org/10.1007/978-1-4899-2575-6_23

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-2577-0

  • Online ISBN: 978-1-4899-2575-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics