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Role of Ubiquinone Diffusion in Mitochondrial Electron Transfer

  • Chapter
Integration of Mitochondrial Function

Abstract

It is presently recognized that the transfer of electrons from substrates to molecular oxygen in mitochondria involves integral membrane protein complexes containing redox groups of increasing redox potentials (Tzagoloff, 1982). According to the original intuition of Green (1966), it is widely accepted that electron transfer between complexes is ensured by mobile components acting as cosubstrates, vz. ubiquinone (Q) and cytochrome c (cyt.c). In particular, ubiquinone holds a central position in the chain, being reduced by a large collection of flavoprotein dehydrogenases and reoxidized by the ubiquinol-cyt.c reductase complex (bql complex or Complex III)(Lenaz et al., 1985 b): such position is likely to mark a strategic point for a regulatory role in electron transfer.

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Author information

Authors and Affiliations

  1. Department of Biology, University of Bologna, 40126, Bologna, Italy

    G. Lenaz, R. Fato, C. Castelluccio, M. Degli Esposti & C. M. Samworth

  2. Department of Biochemistry, University of Bologna, 40126, Bologna, Italy

    M. Battino & G. Parenti Castelli

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  1. G. Lenaz
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  2. R. Fato
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  3. C. Castelluccio
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Editors and Affiliations

  1. Laboratories for Cell Biology, Department of Cell Biology & Anatomy, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599-7090, USA

    John J. Lemasters  & Charles R. Hackenbrock  & 

  2. Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC, 27599, USA

    Ronald G. Thurman

  3. Laboratory of Molecular Biology NIDDK, NIH, Building 2, Room 319, Bethesda, MD, 20892, USA

    Hans V. Westerhoff

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Lenaz, G. et al. (1988). Role of Ubiquinone Diffusion in Mitochondrial Electron Transfer. In: Lemasters, J.J., Hackenbrock, C.R., Thurman, R.G., Westerhoff, H.V. (eds) Integration of Mitochondrial Function. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2551-0_4

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