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Relationships Between Extracellular pH, Intracellular pH, and Cell Injury During ‘Chemical Hypoxia’

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Integration of Mitochondrial Function

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Abstract

Injury to hepatocytes, reversible and irreversible, is a common event in human disease. The essential mechanisms preceding and culminating in irreversible hepatocyte injury, a key phenomenon in all hepatic diseases, are still poorly understood. Therefore, experimental models of hepatocellular injury are critical to our understanding the cellular events producing irreversible liver injury.

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Author information

Authors and Affiliations

  1. Laboratories for Cell Biology, Department of Cell Biology & Anatomy School of Medicine, University of North Carolina at Chapel Hill, Campus Box 7090, 108 Swing Building, Chapel Hill, North Carolina, 27599, USA

    Gregory J. Gores, Anna-Liisa Nieminen, Thomas L. Dawson, Brian Herman & John J. Lemasters

Authors
  1. Gregory J. Gores
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  2. Anna-Liisa Nieminen
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  3. Thomas L. Dawson
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  4. Brian Herman
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  5. John J. Lemasters
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Editor information

Editors and Affiliations

  1. Laboratories for Cell Biology, Department of Cell Biology & Anatomy, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599-7090, USA

    John J. Lemasters  & Charles R. Hackenbrock  & 

  2. Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC, 27599, USA

    Ronald G. Thurman

  3. Laboratory of Molecular Biology NIDDK, NIH, Building 2, Room 319, Bethesda, MD, 20892, USA

    Hans V. Westerhoff

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© 1988 Springer Science+Business Media New York

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Gores, G.J., Nieminen, AL., Dawson, T.L., Herman, B., Lemasters, J.J. (1988). Relationships Between Extracellular pH, Intracellular pH, and Cell Injury During ‘Chemical Hypoxia’. In: Lemasters, J.J., Hackenbrock, C.R., Thurman, R.G., Westerhoff, H.V. (eds) Integration of Mitochondrial Function. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2551-0_39

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  • DOI: https://doi.org/10.1007/978-1-4899-2551-0_39

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-2553-4

  • Online ISBN: 978-1-4899-2551-0

  • eBook Packages: Springer Book Archive

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