Abstract
Our previous studies showed that β-(±)-2-aminobicyclo-(2.2.1)-heptane-2-carboxylic acid (BCH), a synthetic and non-metabolizable amino acid, stimulates liver glutaminase in intact mitochondria and isolated hepatocytes (Zaleski et al., 1986a,b). Since the effect on glutaminase, a protein associated with the inner mitochondrial membrane (McGivan et al., 1980), required preservation of mitochondrial integrity, it was proposed that not the enzyme itself but the membrane is a primary target for BCH action. It has, furthermore, been suggested that interactions between glutaminase and the mitochondrial membrane are controlled by mitochondrial metabolism (Zaleski et al., 1986b).
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Zaleski, J., Zaleska, M., Erecinska, M. (1988). Possible Role of Membrane-Enzyme Interactions in Activation of Pyruvate Carboxylation and Decarboxylation in Mitochondria. In: Lemasters, J.J., Hackenbrock, C.R., Thurman, R.G., Westerhoff, H.V. (eds) Integration of Mitochondrial Function. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2551-0_29
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DOI: https://doi.org/10.1007/978-1-4899-2551-0_29
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