Abstract
Classical equilibrium thermodynamics (Gibbs, 1875–1878) has been used to evaluate many of the central reactions in intermediary metabolism (Holzer, et al., 1956, Huckabee, 1957, Bucher and Klingenberg, 1958, Hohorst, et al., 1959, Williamson, et al., 1967). Such near-equilibrium reactions usually have a high forward and reverse flux relative to the net flux through the enzyme and thus, due to analytical limitations, can not be distinguished from reactions which are in true equilibrium. They differ from true equilibrium reactions in that they violate the law of microscopic reversibility since there is a small net flux instead of a true equilibrium where the forward flux, v1 exactly equals the reverse flux, v−1.
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© 1988 Springer Science+Business Media New York
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Gitomer, W.L., Veech, R.L. (1988). The Near-Equilibrium Thermodynamics Approach to Living Systems. In: Lemasters, J.J., Hackenbrock, C.R., Thurman, R.G., Westerhoff, H.V. (eds) Integration of Mitochondrial Function. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2551-0_16
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DOI: https://doi.org/10.1007/978-1-4899-2551-0_16
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