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Vitamin Nutriture and Requirements of the Elderly

  • Chapter
Nutrition, Aging, and the Elderly

Part of the book series: Human Nutrition ((HUNU,volume 6))

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Abstract

In 1983, 27 million in the U.S. population (11.7%) were over 65 years of age, and by the year 2050 this number is expected to be nearly double (U.S. Census of Population, 1980). In view of this projection, there is concern for maintaining health and function as late as possible into an individual’s life span. In the maintenance of health and prevention of disease, adequacy of nutrition is an important component. At different stages of life, sufficiency of intakes of nutrients is prescribed by the recommended dietary allowances (National Academy of Sciences, 1980), which have been defined as “the levels of intake of essential nutrients considered, in the judgment of the Committee on Dietary Allowances of the Food and Nutrition Board on the basis of available scientific knowledge, to be adequate to meet the known nutritional needs of practically all healthy persons.” The basis for this definition is discussed in Chapter 1. In the case of adults, the 1980 RDAs are divided into two age categories, namely, 23–50 years and 51 years upwards. It is, however, unlikely that the nutrient requirements of a 50-year-old adult are the same as those of a person of 23 years, and it is even more improbable that a person of 90 years has the same needs as an individual aged 51 years. Acceptance of these broad categories for RDAs underlines the paucity of data on which to base narrower age bands.

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References

  • Alexander, M., Emanuel, G., Golin, T., Pinto, J. T., and Rivlin, R. S., 1984, Relation of riboflavin nutriture in healthy elderly to intake of calcium and vitamin supplements: Evidence against riboflavin supplementation, Am. J. Clin. Nutr. 39:540–546.

    CAS  Google Scholar 

  • Ames, S. R., 1974, Age, parity, and vitamin A supplementation and the vitamin E requirement of female rats, Am. J. Clin. Nutr. 27:1017–1025.

    CAS  Google Scholar 

  • Anderson, B. B., Peart, M. B., and Fulford-Jones, C. E., 1970, The measurement of serum pyridoxal by a microbiological assay using Lactobacillus casei, J. Clin. Pathol. 23:232–242.

    Article  CAS  Google Scholar 

  • Andrews, J., Letcher, M., and Brook, M., 1969, Vitamin C supplementation in the elderly: 17-month trial in an old person’s home, Br. Med. J. 2:416–418.

    Article  CAS  Google Scholar 

  • Anonymous, 1979a, Dietary fiber and vitamin B-12 balance, Nutr. Rev. 37:116-118.

    Google Scholar 

  • Anonymous, 1979b, Pitfalls in the diagnosis of vitamin B-12 deficiency by radiodilution assay, Nutr. Rev. 37:313-316.

    Google Scholar 

  • Anonymous, 1981, Biotin deficiency as a complication of incomplete parenteral nutrition, Nutr. Rev. 39:274-277.

    Google Scholar 

  • Anonymous, 1982a, Vitamin K, vitamin E and the coumarin drugs, Nutr. Rev. 40:180-182.

    Google Scholar 

  • Anonymous, 1982b, Abnormal plasma prothrombin in the diagnosis of subclinical vitamin K deficiency, Nutr. Rev. 40:298-300.

    Google Scholar 

  • Anwar, M., 1978, Nutritional hypovitaminosis-D and the genesis of osteomalacia in the elderly, J. Am. Geriatr. Soc. 7:309–317.

    Google Scholar 

  • Ardeman, S., and Chanarin, I., 1966, Intrinsic factor secretion in gastric atrophy, Gut 7:99–101.

    Article  CAS  Google Scholar 

  • Armbrecht, H. J., Zenser, T. V., and Davis, B. B., 1980a, Effect of age on the conversion of 25-hydroxyvitamin D3 to 1,25-dihydroxyvitamin D3 by kidney of rat, J. Clin. Invest. 66:1118–1123.

    Article  CAS  Google Scholar 

  • Armbrecht, H. J., Zenser, T. V., Gross, C. J., and Davis, B. B., 1980b, Adaptation to dietary calcium and phosphorus restriction changes with age in the rat, Am. J. Physiol. 239:E322–E327.

    CAS  Google Scholar 

  • Armbrecht, H. J., Wongsurawat, N., Zenser, T. V., and Davis, B. B., 1982, Differential effects of parathyroid hormone on the renal 1,25-di-hydroxyvitamin D3 and 24,25-dihydroxyvitamin D3 production of young and adult rats, Endocrinology 111:1339–1344.

    Article  CAS  Google Scholar 

  • Armbrecht, H. J., Forte, L. R., and Halloran, B. P., 1984, Effect of age and dietary calcium on renal 25-(OH)D3 metabolism, serum 1,25-(OH)2D3, and PTH, Am. J. Physiol. 246:E266–270.

    CAS  Google Scholar 

  • Attwood, E. C., Robey, E., Kramer, J. J., Ovenden, N., Snape, S., Ross, J., and Bradley, F., 1978, A survey of the haematological, nutritional and biochemical state of the rural elderly with particular reference to vitamin C., Age Aging 7:46–56.

    Article  CAS  Google Scholar 

  • Babu, S., and Srikantia, S. G., 1976, Availability of folates from some food, Am. J. Clin. Nutr. 29:376–379.

    CAS  Google Scholar 

  • Bailey, L. B., Wagner, P. A., Christakis, G. J., Araujo, P. E., Appledorf, H., Davis, C. G., Masteryanni, J., and Dinning, J. S., 1979, Folacin and iron status and hematological findings in predominantly black elderly persons from urban low income households, Am. J. Clin. Nutr. 32:2346–2353.

    CAS  Google Scholar 

  • Bailey, L. B., Wagner, P. A., Christakis, G. J., Araujo, P. E., Appledorf, H., Davis, C. G., Dorsey, E., and Dinning, J. S., 1980, Vitamin B-12 status of elderly persons from urban low income households, J. Am. Geriatr. Soc. 28:276–278.

    CAS  Google Scholar 

  • Bailey, L. B., Cerda, J. J., Bloch, B. S., Busby, M. J., Vargas, L., Chandler, C. J., and Halsted, C. H., 1984, Effect of age on poly-and monoglutamyl folacin absorption in human subjects, J. Nutr. 114:1770–1776.

    CAS  Google Scholar 

  • Baker, E. M., 1967, Vitamin C requirements in stress, Am. J. Clin. Nutr. 20:583–590.

    CAS  Google Scholar 

  • Baker, H., Frank, O., Feingold, S., and Leevy, C. M., 1967, Vitamin distribution in human plasma proteins, Nature 215:84–85.

    Article  CAS  Google Scholar 

  • Baker, H., Jaslow, S. P., and Frank, O., 1978, Severe impairment of dietary folate utilization in the elderly, J. Am. Geriatr. Soc. 26:218–221.

    CAS  Google Scholar 

  • Baker, H., Frank, O., Thind, I. S., Jaslow, S. P., and Louria, D. B., 1979, Vitamin profiles in elderly persons living at home or in nursing homes, versus profile in healthy young subjects, J. Am. Geriatr. Soc. 27:444–450.

    CAS  Google Scholar 

  • Baker, M. R., Peacock, M., and Nordin, B. E. C., 1980, The decline in vitamin D status with age, Age Aging 9:249–252.

    Article  CAS  Google Scholar 

  • Baksi, S. N., and Kenny, A. D., 1981, Vitamin D metabolism in aged Japanese quail: Dietary calcium and estrogen effects, Am. J. Physiol. 241:E275–E280.

    CAS  Google Scholar 

  • Bamji, M. S., 1981, Laboratory tests for the assessment of vitamin nutritional status, in: Vitamins in Human Biology and Medicine (M. H. Briggs, ed.), CRC Press, Boca Raton, FL, pp. 1–28.

    Google Scholar 

  • Barnard, D. L., and Heaton, K. W., 1973, Bile acids and vitamin A absorption in man: The effects of two bile acid-binding agents, cholestyramine and lignin, Gut 14:316–318.

    Article  CAS  Google Scholar 

  • Barnes, K. J., and Chen, L. H., 1981, Vitamin E status of the elderly in central Kentucky, J. Nutr. Elderly 1:41–49.

    Article  Google Scholar 

  • Barr, S. I., Chrysomilides, S. A., Willis, E. J., and Beattie, B. L., 1983, Nutrient intakes of the old elderly: A study of female residents of a long-term care facility, Nutr. Res. 3:417–431.

    Article  Google Scholar 

  • Barragry, J. M., France, M. W., Corless, D., Gupta, S. P., Switala, S., Boucher, B. K., and Cohen, R. D., 1978, Intestinal cholecalciferol absorption in the elderly and in younger adults, Clin. Sci. Mol. Med. 55:213–220.

    CAS  Google Scholar 

  • Bates, C. J., Rutishauser, I. H. E., Black, A. E., Paul, A. A., Mandai, A. R., and Patnaik, B. K., 1977, Long-term vitamin status and dietary intake of healthy elderly subjects: 2. Vitamin C., Br. J. Nutr. 42:43–56.

    Article  Google Scholar 

  • Bates, C. J., Fleming, M., Paul, A. A., Black, A. E., and Mandai, A. R., 1980, Folate status and its relation to vitamin C in healthy elderly men and women, Age Aging 9:241–248.

    Article  CAS  Google Scholar 

  • Baum, R. A., and Iber, F. L., 1984, Thiamin—the interaction of aging, alcoholism, and malabsorption in various populations, World Rev. Nutr. Diet. 44:85–116.

    CAS  Google Scholar 

  • Beadle, P. C., 1977, Sunlight, ozone and vitamin D, Br. J. Dermatol. 97:585–591.

    Article  CAS  Google Scholar 

  • Beauchene, R. E., and Davis, T. A., 1979, The nutritional status of the aged in the USA, Age 2:23–28.

    Article  CAS  Google Scholar 

  • Bell, N. H., 1985, Vitamin D-endocrine system, J. Clin. Invest. 76:1–6.

    Article  CAS  Google Scholar 

  • Belsey, R., Clark, M. B., Bernat, M., Glowacki, J., Holick, M. F., DeLuca, H. F., and Potts, J. T., 1974, The physiologic significance of plasma transport of vitamin D and metabolites, Am. J. Med. 57:50–56.

    Article  CAS  Google Scholar 

  • Berg, B. N., 1951, Muscular dystrophy in aging rats, J. Gerontol. 11:134–139.

    Article  Google Scholar 

  • Betts, N. M., and Vivian, V. M., 1984, The dietary intake of noninstitutionalized elderly, J. Nutr. Elderly 3:3–11.

    Article  Google Scholar 

  • Bhanthumnavin, K., Wright, J. R., and Halsted, C. H., 1974, Intestinal transport of tritiated folic acid (3H-PGA) in the everted gut sac of different aged rats, Johns Hopkins Med. J. 135:152–160.

    CAS  Google Scholar 

  • Bien, J. G., 1984, Vitamin E, in: Present Knowledge in Nutrition, The Nutrition Foundation, Washington, pp. 226–240.

    Google Scholar 

  • Binder, H. J., Herting, D. C., Hurst, V., Finch, S. C., and Spiro, H. M., 1965, Tocopherol deficiency in man, N. Engl. J. Med. 273:1289–1297.

    Article  CAS  Google Scholar 

  • Blanchard, R. A., Furie, B. C., Jorgensen, M., Kruger, S. F., and Furie, B., 1981, Acquired vitamin K-dependent carboxylation deficiency in liver disease, N. Engl. J. Med. 305:242–248.

    Article  CAS  Google Scholar 

  • Blanchard, R. A., Furie, B. C., Kruger, S. F., Waneck, G., Jorgensen, M. J., and Furie, B., 1983, Immunoassays of human prothrombin species which correlate with functional coagulant activities, J. Lab. Clin. Med. 101:242–255.

    CAS  Google Scholar 

  • Boger, W. P., Wright, L. D., Strickland, S. C., Gylpe, J. S., and Ciminera, J. L., 1955, Vitamin B-12: Correlation of serum concentration with age, Proc. Soc. Exp. Biol. Med. 89:375–381.

    Article  CAS  Google Scholar 

  • Bonati, B., Nani, S., and Rancati, G. B., 1956, Eliminazione urinaria di vitamine del complesso B nei vecchi, Acta Vitaminol. 10:241–244.

    CAS  Google Scholar 

  • Bonjour, J. P., 1977, Biotin in man’s nutrition and therapy—a review, J. Vitam. Nutr. Res. 47:107–118.

    CAS  Google Scholar 

  • Bonjour, J. P., 1980, Vitamins and alcoholism. III. Vitamin B6, Int. J. Vitam. Nutr. Res. 50:215–230.

    CAS  Google Scholar 

  • Bonjour, J. P., 1984, Biotin, in: Handbook of vitamins. Nutritional, Biochemical and Clinical Aspects (L. J. Machlin, ed.), Marcel Dekker, New York, pp. 403–436.

    Google Scholar 

  • Bowman, B. B., and Rosenberg, I. H., 1982, Assessment of the nutritional status of the elderly, Am. J. Clin. Nutr. 35:1142–1151.

    CAS  Google Scholar 

  • Brandt, L. J., Bernstein, L. H., and Wagle, A., 1977, Production of vitamin B12 analogues in patients with small bowel bacterial overgrowth, Ann. Intern. Med. 87:546–551.

    Article  CAS  Google Scholar 

  • Breen, K. J., Buttigieg, R., Iossifidis, S., Lourensz, C., and Wood, B., 1985, Jejunal uptake of thiamin hydrochloride in man: Influence of alcoholism and alcohol, Am. J. Clin. Nutr. 42:121–126.

    CAS  Google Scholar 

  • Brin, M., Dibble, M. V., Peel, A., McMullen, E., Bourquin, A., and Chen, N., 1965, Some preliminary findings on the nutritional status of the aged in Onondaga County, New York, Am. J. Clin. Nutr. 7:240–258.

    Google Scholar 

  • Brody, T., Shane, B., and Stokstad, E. L. R., 1984, Folic acid, in: Handbook of Vitamins. Nutritional, Biochemical and Clinical Aspects (L. J. Machlin, ed.), Marcel Dekker, New York, pp. 459–496.

    Google Scholar 

  • Brook, M., and Grimshaw, J. J., 1968, Vitamin C concentration of plasma and leukocytes as related to smoking habit, age, and sex of humans, Am. J. Clin. Nutr. 21:1254–1258.

    CAS  Google Scholar 

  • Burr, M. L., Hurley, R. J., and Sweetnam, P. M., 1974a, Vitamin C supplementation of old people with low blood levels, Gerontol. Clin. 17:236–243.

    Article  Google Scholar 

  • Burr, M. L., Sweetnam, P. M., Hurley, R. J., and Powell, G. H., 1974b, Effects of age and intake on plasma-ascorbic acid levels, Lancet 1:163–164.

    Article  CAS  Google Scholar 

  • Campbell, G. A., Kamin, J. R., Hosking, D. J., and Boyd, R. V., 1984, How common is osteomalacia in the elderly? Lancet 1:386–388.

    Article  Google Scholar 

  • Cape, R. T. D., and Shinton, N. K., 1961, Serum vitamin B-12 concentration in the elderly, Gerontol. Clin. 3:163–172.

    Article  CAS  Google Scholar 

  • Carmel, R., 1978, Nutritional vitamin B-12 deficiency. Possible contributory role of subtle vitamin B-12 malabsorption, Ann. Intern. Med. 88:647–649.

    Article  CAS  Google Scholar 

  • Cheli, R., Simon, L., Aste, H., Figus, I. A., Nicold, G., Bajtai, A., and Puntoni, R., 1980, Atrophic gastritis and intestinal metaplasia in asymptomatic Hungarian and Italian populations, Endoscopy 12:105–108.

    Article  CAS  Google Scholar 

  • Chen, L. H., 1974, The effect of age and dietary vitamin E on the tissue lipid peroxidation of mice, Nutr. Rep. Int. 10:339–344.

    CAS  Google Scholar 

  • Chen, L. H., 1981, Vitamin E and aging, in: Handbook of Geriatric Nutrition (J. M. Hsu, ed.), Noyes, Park Ridge, NJ, pp. 176–187.

    Google Scholar 

  • Chen, L. H., and Fan Chiang, W. L., 1981, Biochemical evaluation of riboflavin and vitamin B-6 status of institutionalized and noninstitutionalized elderly in central Kentucky, Int. J. Vitam. Nutr. Res. 51:232–238.

    CAS  Google Scholar 

  • Chen, L. H., Hsu, S. J., Huang, P. C., and Chen, J. S., 1977, Vitamin E status of Chinese population in Taiwan, Am. J. Clin. Nutr. 30:728–735.

    CAS  Google Scholar 

  • Cheng, L., Cohen, M., and Bhagavan, H. N., 1985, Vitamin C and the elderly, in: Handbook of Nutrition in the Aged (R. R. Watson, ed.) CRC Press, Boca Raton, FL, pp. 157–185.

    Google Scholar 

  • Chernish, S. M., Helmer, O. M., Fouts, P. J., and Kohlstaedt, K. G., 1957, The effect of intrinsic factor on the absorption of vitamin B-12 in older people, Am. J. Clin. Nutr. 5:651–658.

    CAS  Google Scholar 

  • Chhabra, R. S., 1984, Retinoids and drug-metabolizing enzymes, in: Drugs and Nutrients. Drug Nutrient Interactions (D. A. Roe and T. C. Campbell, eds.), Marcel Dekker, New York, pp. 95–117.

    Google Scholar 

  • Chieffi, M., and Kirk, J. E., 1951, Vitamin studies in middle-aged and old individuals. VI. Tocopherol plasma concentrations, J. Gerontol. 6:17–18.

    Article  CAS  Google Scholar 

  • Chow, B. F., 1958, Vitamin B-12 in relationship to aging, Gerontologica 2:213–221.

    Article  CAS  Google Scholar 

  • Chow, B. F., Gilbert, J. P., Okuda, K., and Rosenblum, C., 1956a, The urinary excretion test for absorption of vitamin B-12. I. Reproducibility of results and agewise variation, Am. J. Clin. Nutr. 4:142–146.

    CAS  Google Scholar 

  • Chow, B. F., Wood, R., Horonick, A., and Okuda, K., 1956b, Agewise variation of vitamin B-12 serum levels, J. Gerontol. 11:142–146.

    Article  CAS  Google Scholar 

  • Chrisley, B. M., and Driskell, J. A., 1979, Vitamin B-6 status of adults in Virginia, Nutr. Rep. Int. 19:553–560.

    CAS  Google Scholar 

  • Chytil, F., 1984, Retinoic acid: Biochemistry, pharmacology, toxicology, and therapeutic use, Pharmacol. Rev. 36(2 Suppl.):93S–100S.

    CAS  Google Scholar 

  • Colby, H. D., Kramer, R. E., Greiner, J. W., Robinson, D. A., Krause, R. F., and Canady, W. J., 1975, Heaptic drug metabolism in retinol-deficient rats, Biochem. Pharmacol. 24:1645–1646.

    Article  CAS  Google Scholar 

  • Colman, N., Green, R., and Metz, J., 1975, Prevention of folate deficiency by food fortification. II. Absorption of folic acid from fortified staple foods, Am. J. Clin. Nutr. 28:459–464.

    CAS  Google Scholar 

  • Colvin, B. T., and Lloyd, M. J., 1977, Severe coagulation defect due to a dietary deficiency of vitamin K, J. Clin. Pathol. 30:1147–1148.

    Article  CAS  Google Scholar 

  • Conely, J., Sumner, D., McKinlay, A., Mclntosh, W., and Dunnigan, M. G., 1977, Prevention of vitamin D deficiency in the elderly, Br. Med. J. 2:1668.

    Article  CAS  Google Scholar 

  • Connelly, T. J., Becker, D. O. A., and McDonald J. W., 1982, Bachelor scurvy, Int. J. Dermatol. 21:209–211.

    Article  CAS  Google Scholar 

  • Corless, D., Boucher, B. J., Beer, M., Gupta, S. P., and Cohen, R. D., 1975, Vitamin D status in long-stay geriatric patients, Lancet 1:1404–1406.

    Article  CAS  Google Scholar 

  • Corless, D., Gupta, S. P., Sattar, D. A., Switala, S., and Boucher, B. J., 1979, Vitamin D status of residents of an old people’s home and long-stay patients, Gerontology 25:350–355.

    Article  CAS  Google Scholar 

  • Corrigan, J. J., Jr., 1982, The effect of vitamin E on warfarin-induced vitamin K deficiency, Ann. N.Y. Acad. Sci. 393:361–368.

    Article  CAS  Google Scholar 

  • Corrigan, J. J., Jr., and Ulfers, L. L., 1981, Effect of vitamin E on prothrombin levels in warfarin-induced vitamin K deficiency, Am. J. Clin. Nutr. 34:1701–1705.

    CAS  Google Scholar 

  • Cullen, R. W., and Oace, S. M., 1978, Methylmalonic acid and vitamin B-12 excretion of rats consuming diets varying in cellulose and pectin, J. Nutr. 108:640–648.

    CAS  Google Scholar 

  • Daiger, S. P., Schanfield, M. S., and Cavalli-Sforza, L. L., 1975, Group-specific component (gc) proteins bind vitamin D and 25-hydroxyvitamin D, Proc. Natl. Acad. Sci. U.S.A. 72:2076–2080.

    Article  CAS  Google Scholar 

  • Dakshinamurti, K., and Bhagavan, H. (eds.), 1985, Biotin, Ann. N.Y. Acad. Sci. 447:1–441.

    Google Scholar 

  • Danford, D. E., and Munro, H. N., 1980, The water-soluable vitamins: Vitamin B complex and ascorbic acid, in: The Pharmacological Basis of Therapeutics, 6th ed. (L. S. Goodman and A. G. Gilman, eds.), New York, Macmillan, pp. 1560–1582.

    Google Scholar 

  • Danford, D. E., and Munro, H. N., 1988, Liver in relation to B-vitamins, in: The Liver: Biology and Pathobiology, 2nd ed. (I. M. Arias, w. B. Jakoby, H. Popper, D. Schachter, and D. A. Shafritz, eds.), Raven Press, New York, pp. 965–984.

    Google Scholar 

  • Darby, W. J., Ferguson, M. E., Furman, R. H., Lemley, J. M., Ball, C. T., and Meneely, G. R., 1949, Plasma tocopherols in health and disease, Ann. N.Y. Acad. Sci. 52:328–333.

    CAS  Google Scholar 

  • Dattani, J. T., Exton-Smith, A. N., and Stephen, J. M. L., 1984, Vitamin D status of the elderly in relation to age and exposure to sunlight, Hum. Nutr. Clin. Nutr. 38C:131–137.

    CAS  Google Scholar 

  • Davie, M., and Lawson, D. E. M., 1980, Assessment of plasma 25-hydroxyvitamin D response to ultraviolet irradiation over a controlled area in young and elderly subjects, Clin. Sci. 58:235–242.

    CAS  Google Scholar 

  • Davies, H. E. F., Davies, J. E. W., Hughes, R. E., and Jones, E., 1984, Studies on the absorption of L-xyloascorbic acid (vitamin C) in young and elderly subjects, Hum. Nutr. Clin. Nutr. 38C:463–471.

    CAS  Google Scholar 

  • Dawson, D. W., Sawers, A. H., and Sharma, R. K., 1984, Malabsorption of protein-bound vitamin B-12, Br. Med. J. 288:675–678.

    Article  CAS  Google Scholar 

  • Del Tredici, A. M., Bernstein, A. L., and Chinn, K., 1985, Carpal tunnel syndrome and vitamin B 6 therapy, in: Vitamin B-6: Its Role in Health and Disease (J. Leklem and B. Reynolds, eds.) Alan R. Liss, New York, pp. 459–462.

    Google Scholar 

  • DeLuca, H. F., 1972, Parathyroid hormone as a trophic hormone for 1,25-dihydroxyvitamin D3, the metabolically active form of vitamin D, N. Engl. J. Med. 287:250–251.

    Article  CAS  Google Scholar 

  • Desai, I. D., 1968, Plasma tocopherol levels in normal adults, Can. J. Physiol. Pharmacol. 46:819–822.

    Article  CAS  Google Scholar 

  • Devgun, M. S., Paterson, C. R., Johnson, B. E., and Cohen, C., 1981, Vitamin D nutrition in relation to season and occupation, Am. J. Clin. Nutr. 34:1501–1504.

    CAS  Google Scholar 

  • Dibble, M. V., Brin, M., Thiele, V. F., Peel, A., Chen, N., and McMullen, E., 1967, Evaluation of the nutritional status of elderly subjects, with a comparison between fall and spring, J. Am. Geriatr. Soc. 15:1031–1061.

    CAS  Google Scholar 

  • Diet, Nutrition, and Cancer Report, 1982, National Academy Press, Washington, pp. 138-144.

    Google Scholar 

  • Dju, M. Y., Mason, K. E., and Flier, L. J., 1958, Vitamin E (tocophero 1) in human tissues from birth to old age, Am. J. Clin. Nutr. 6:50–60.

    CAS  Google Scholar 

  • Doi, K., Matsuura, M., Kawara, A., Tanaka, T., and Baba, S., 1983, Influence of dietary fiber (konjac mannan) on absorption of vitamin B-12 and vitamin E, Tohoku J. Exp. Med. 141:677–681.

    Article  CAS  Google Scholar 

  • Doisy, E. A., Jr., 1961, Nutritional hypoprothrombinemia and metabolism of vitamin K, Fed. Proc. 20:989–994.

    CAS  Google Scholar 

  • Doscherholmen, A., Ripley, D., Chang, S., and Silvis, S. E., 1977, Influence of age and stomach function on serum vitamin B-12 concentration, Scand. J. Gastroenterol. 12:313–319.

    Article  CAS  Google Scholar 

  • Draper, H. H., 1958, Physiological aspects of aging. I. Efficiency of absorption and phosphorylation of radiothiamine, Proc. Soc. Exp. Biol. Med. 97:121–124.

    Article  CAS  Google Scholar 

  • Driskell, J. A., 1984, Vitamin B-6, in: Handbook of Vitamins. Nutritional, Biochemical and Clinical Aspects (L. J. Machlin, ed.), Marcel Dekker, New York, pp. 379–401.

    Google Scholar 

  • Droller, H., and Dossett, J. A., 1959, Vitamin B-12 levels in senile dementia and confusional states, Gerontol. Clin. 1:96–106.

    Article  CAS  Google Scholar 

  • Ellenbogen, L., 1984. Vitamin B-12, in: Handbook of Vitamins. Nutritional, Biochemical and Clinical Aspects (L. J. Machlin, ed.), Marcel Dekker, New York, pp. 497–548.

    Google Scholar 

  • Ellis, J. M., Folkers, K., Levy, M., Shizuknishi, S., Lewandowski, J., Nishi, S., Schubert, H. A., and Ulrich, R., 1982, Response of vitamin B-6 deficiency and the carpal tunnel syndrome to pyridoxine, Proc. Natl. Acad. Sci. U.S.A. 79:7494–7498.

    Article  CAS  Google Scholar 

  • Eisborg, L., 1976, Reversible malabsorption of folic acid in the elderly with nutritional folate deficiency, Acta Haematol. 55:140–147.

    Article  Google Scholar 

  • Eisborg, L., Lund, V., and Bastrup-Madsen, P., 1976, Serum vitamin B-12 levels in the aged, Acta Med. Scand. 200:309–314.

    Article  Google Scholar 

  • Elsborg, L., Nielsen, J. A., Bertram, U., Helms, P., Nielsen, K., and Rosenquist, A., 1983, The intake of vitamins and minerals by the elderly at home, Int. J. Vitam. Nutr. Res. 53:321–329.

    CAS  Google Scholar 

  • Elwood, P. C., Shinton, N. K., Wilson, C. I. D., Sweetnam, P., and Frazer, A. C., 1971, Haemoglobin, vitamin B-12 and folate levels in the elderly, Br. J. Haematol. 21:557–563.

    Article  CAS  Google Scholar 

  • Emerson, G. A., and Evans, H. M., 1939a, Restoration of fertility in successively older vitamin E-low female rats, J. Nutr. 18:501–506.

    CAS  Google Scholar 

  • Emerson, G. A., and Evans, H. M., 1939b, Degrees of sterility in female vitamin E-low rats, Am. J. Physiol. 126:484.

    Google Scholar 

  • Farrell, P. M., 1980, Deficiency states, pharmacological effects and nutrient requirements, in: Vitamin E, a Comprehensive Treatise (L. J. Machlin, ed.), Marcel Dekker, New York, pp. 520–620.

    Google Scholar 

  • Fischer, S., Hendricks, D. G., and Mahoney, A. W., 1978, Nutritional assessment of senior rural Utahns by biochemical and physical measurements, Am. J. Clin. Nutr. 31:667–672.

    Google Scholar 

  • Fleming, B. B., and Barrows, C. H., Jr., 1982a, The influence of aging on intestinal absorption of vitamins A and D by the rat, Exp. Gerontol. 17:115–120.

    Article  CAS  Google Scholar 

  • Fleming, B. B., and Barrows, C. H., 1982b, The influence of aging on intestinal absorption of vitamin B-12 and niacin in rats, Exp. Gerontol. 17:121–126.

    Article  CAS  Google Scholar 

  • Folkers, K., Ellis, J., Watanabe, T., Saji, S., and Kaji, M., 1978, Biochemical evidence for a deficiency of vitamin B-6 in carpal tunnel syndrome based on a crossover clinical study, Proc. Natl. Acad. Sei U.S.A. 75:3410–3412.

    Article  CAS  Google Scholar 

  • Fonda, M. L., and Eggers, D. K., 1980, Vitamin B-6 metabolism in the blood of young adult and senescent mice, Exp. Gerontol. 15:465–472.

    Article  CAS  Google Scholar 

  • Fonda, M. L., Acree, D. W., and Auerbach, S. B., 1973, The relationship of gamma-aminobutyrate levels and its metabolism to age in brains of mice, Arch. Biochem. Biophys. 159:622–628.

    Article  CAS  Google Scholar 

  • Fonda, M. L., Eggers, D. K., and Metha, R., 1980a, Vitamin B-6 metabolism in the livers of young adult and senescent mice, Exp. Gerontol. 15:457–463.

    Article  CAS  Google Scholar 

  • Fonda, M. L., Eggers, D. K., Auerbach, S., and Fritsch, L., 1980b, Vitamin B-6 metabolism in the brains of young adult and senescent mice, Exp. Gerontol. 15:473–478.

    Article  CAS  Google Scholar 

  • Fox, H. M., 1984, Pantothenic acid, in: Handbook of Vitamins. Nutrition, Biochemical and Clinical Aspects (L. J. Machlin, ed.) Marcel Dekker, New York, pp. 437–458.

    Google Scholar 

  • Foy, H., and Mbaya, V., 1977, Riboflavin, Prog. Food Nutr. Sci. 2:357–394.

    CAS  Google Scholar 

  • Frazier, D. R., 1980, Regulation of the metabolism of vitamin D, Physiol. Rev. 60:551–613.

    Google Scholar 

  • Frick, P. G., Riedler, G., and Brogli, H., 1967, Dose response and minimal daily requirement for vitamin K in man, J. Appl. Physiol. 23:387–389.

    CAS  Google Scholar 

  • Fuhr, A., Johnson, R. E., Kaunitz, H., and Slanitz, C. A., 1949, Increased tocopherol requirements during the rat’s menopause, Ann. N.Y. Acad. Sci. 52:83–87.

    CAS  Google Scholar 

  • Fujisawa, J., Kida, K., and Matsuda, H., 1984, Role of change in vitamin D metabolism with age on calcium and phosphorus metabolism in normal human subjects, J. Clin. Endocrinol. Metab. 59:719–726.

    Article  CAS  Google Scholar 

  • Gabriel, E., Machlin, L. J., Filipski, R., and Nelson, J., 1980, Influence of age on the vitamin E requirement for resolution of necrotizing myopathy, J. Nutr. 110:1372–1379.

    CAS  Google Scholar 

  • Gaffney, G. W., Horonick, A., Okuda, K., Meier, P., Chow, B. F., and Shock, N. W., 1957, Vitamin B-12 serum concentration in 528 apparently healthy human subjects of ages 12-94, J. Gerontol. 12:32–38.

    Article  CAS  Google Scholar 

  • Gallagher, J. C., Riggs, B. L., Eisman, J., Hamstra, A., Arnaud, S. B., and DeLuca, H. F., 1979, Intestinal calcium absorption and serum vitamin D metabolites in normal subjects and osteoporotic patients, J. Clin. Invest. 64:729–736.

    Article  CAS  Google Scholar 

  • Gallagher, J. C., Riggs, B. L., Jerpbak, C. M., and Arnaud, C. D., 1980, The effect of age on serum immunoreactive parathyroid hormone in normal and osteoporotic women, J. Lab. Clin. Med. 95:373–385.

    CAS  Google Scholar 

  • Garabedian, M., Holick, M. F., DeLuca, H. F., and Boyle, I. T., 1972, Control of 25-hydroxycholecalciferol metabolism by parathyroid glands, Proc. Natl. Acad. Sci. U.S.A. 69:1673–1676.

    Article  CAS  Google Scholar 

  • Garry, P. J., and Hunt, W. C., 1986, Biochemical assessment of vitamin status in the elderly: Effect of dietary and supplemental intakes, in: Nutrition and Aging (M. L. Hutchinson and H. N. Munro, eds.), Academic Press, Orlando, FL, pp. 117–137.

    Chapter  Google Scholar 

  • Garry, P. J., Goodwin, J. S., Hunt, W. C., Hooper, E. M., and Leonard, A. G., 1982a, Nutritional status in a healthy elderly population: Dietary and supplemental intakes, Am. J. Clin. Nutr. 36:319–331.

    CAS  Google Scholar 

  • Garry, P. J., Goodwin, J. S., and Hunt, W. C., 1982b, Nutritional status in a healthy elderly population: Riboflavin, Am. J. Clin. Nutr. 36:902–909.

    CAS  Google Scholar 

  • Garry, P. J., Goodwin, J. S., Hunt, W. C., and Gilbert, B. A., 1982c, Nutritional status in a healthy elderly population: Vitamin C., Am. J. Clin. Nutr. 36:332–339.

    CAS  Google Scholar 

  • Garry, P. J., Goodwin, J. S., and Hunt, W. C., 1984, Folate and vitamin B-12 status in a healthy elderly population, J. Am. Geriatr. Soc. 32:719–726.

    CAS  Google Scholar 

  • Gehrmann, G., 1965, Pyridoxine-responsive anemias, Br. J. Haematol. 11:86–91.

    Article  CAS  Google Scholar 

  • Giannella, R. A., Broitman, S. A., and Zamcheck, N., 1971, Vitamin B-12 uptake by intestinal microorganisms: Mechamisms and relevance to syndromes of intestinal bacterial overgrowth, J. Clin. Invest. 50:1100–1107.

    Article  CAS  Google Scholar 

  • Gillum, H. L., Morgan, A. F., and Sailer, F., 1955, Nutritional status of the aging: V. Vitamin A and carotene, J. Nutr. 55:655–670.

    CAS  Google Scholar 

  • Girdwood, R. H., Thomson, A. D., and Williamson, J., 1967, Folate status in the elderly, Br. Med. J. 2:670–672.

    Article  CAS  Google Scholar 

  • Glass, G. B. J., Goldbloom, A. A., Boyd, L. J., Laughton, R., Rosen, S., and Rich, M., 1956, Intestinal absorption and hepatic uptake of radioactive vitamin B-12 in various age groups and the effect of intrinsic factor preparations, Am. J. Clin. Nutr. 4:124–133.

    CAS  Google Scholar 

  • Goodman, D. S., 1984, Overview of current knowledge of metabolism of vitamin A and carotenoids, J. Natl. Cancer Inst. 73:1375–1379.

    CAS  Google Scholar 

  • Gracey, M., 1979, The contaminated small bowel syndrome: Pathogenesis, diagnosis, and treatment, Am. J. Clin. Nutr. 32:234–243.

    CAS  Google Scholar 

  • Gray, G. E., Paganini-Hill, A., and Ross, R. K., 1983, Dietary intake and nutrient supplement use in a southern California retirement community, Am. J. Clin. Nutr. 38:122–128.

    CAS  Google Scholar 

  • Gray, R. W., and Gambert, S. R., 1982, Effect of age on plasma 1,25-(OH)2 vitamin D in the rat, Age 5:54–56.

    Article  CAS  Google Scholar 

  • Griffiths, L. L., Brocklehurst, J. C., Scott, D. L., Marks, J., and Blackley, J., 1967, Thiamine and ascorbic acid levels in the elderly, Gerontol. Clin. 9:1–10.

    Article  CAS  Google Scholar 

  • Grimble, R. F., and Hughes, R. E., 1968, The glutathione:dehydroascorbate oxidoreductase activity of guinea-pigs from two different age groups, Life Sci. 7:383–386.

    Article  CAS  Google Scholar 

  • Grinna, L. S., 1976, Effect of dietary alpha-tocopherol on liver microsomes and mitochondria of aging rats, J. Nutr. 106:918–929.

    CAS  Google Scholar 

  • Gubler, C. J., 1984, Thiamin, in: Handbook of vitamins. Nutritional, Biochemical and Clinical Aspects (L. J. Machlin, ed.), Marceil Dekker, New York, pp. 245–298.

    Google Scholar 

  • Guggenheim, K., Kravitz, M., Tal, R., and Kaufman, N. A., 1979, Biochemical parameters of vitamin D nutriture in old people in Jerusalem, Nutr. Metab. 23:172–178.

    Article  CAS  Google Scholar 

  • Guilland, J. C., Bereksi-Reguig, B., Lequeu, B., Moreau, D., Klepping, J., and Richard, D., 1984, Evaluation of pyridoxine intake and pyridoxine status among aged institutionalized people, Int. J. Vitam. Nutr. Res. 54:185–193.

    CAS  Google Scholar 

  • Gyorgy, P., 1971, Developments leading to the metabolic role of vitamin B-6, Am. J. Clin. Nutr. 24:1250–1256.

    CAS  Google Scholar 

  • Hahn, T. J., Birge, S. J., Scharp, C. R., and Avioli, L. V., 1972, Phenobarbital-induced alterations in vitamin D metabolism, J. Clin. Invest. 51:741–748.

    Article  CAS  Google Scholar 

  • Hall, C. A., 1982, The luxus vitamins A and B-12: Reply to McLaren, Am. J. Clin. Nutr. 35:772–774.

    CAS  Google Scholar 

  • Hamfelt, A., 1964, Age variation of vitamin B-6 metabolism in man, Clin. Chim. Acta 10:48–54.

    Article  CAS  Google Scholar 

  • Hampton, D. J., Chrisley, B. M., and Driskell, J. A., 1977, Vitamin B-6 status of the elderly in Montgomery County, VA, Nutr. Rep. Int. 16:743–750.

    CAS  Google Scholar 

  • HANES II, 1982, Health and Nutritional Examination Survey No. 2. Dietary intake source data, United States, 1976–80, National Center for Health Statistics, Hyattsville, MD.

    Google Scholar 

  • Hankes, L. V., 1984, Nicotinic acid and nicotinamide, in: Handbook of Vitamins. Nutritional, Biochemical and Clinical Aspects (L. J. Machlin, ed.), Marcel Dekker, New York, pp. 329–378.

    Google Scholar 

  • Harding, A. E., Matthews, S., Jones, S., Ellis, C. J. K., Booth, I. W., and Muller, D. P. R., 1985, Spinocerebellar degeneration associated with a selective defect of vitamin E absorption, N. Engl. J. Med. 313:32–35.

    Article  CAS  Google Scholar 

  • Harrill, I., and Cervone, N., 1977, Vitamin status of older women, Am. J. Clin. Nutr. 30:431–440.

    CAS  Google Scholar 

  • Hayes, A. N., Willans, D. J., and Skelton, D., 1985, Vitamin B-12 (cobalamin) and folate blood levels in geriatric reference group as measured by two kits, Clin. Biochem. 18:56–61.

    Article  CAS  Google Scholar 

  • Hayes, M. J., Langman, M. J. S., and Short, A. H., 1975, Changes in drug metabolism with increasing age: 1. Warfarin binding and plasma proteins, Br. J. Clin. Pharmacol. 2:69–72.

    CAS  Google Scholar 

  • Hazell, K., and Baloch, K. H., 1970, Vitamin K deficiency in the elderly, Gerontol. Clin. 12:10–17.

    Article  CAS  Google Scholar 

  • Hepburn, F. N., 1982, The USDA national nutrient data bank, Am. J. Clin. Nutr. 35:1297–1301.

    CAS  Google Scholar 

  • Hewick, D. S., Moreland, T. A., Shepherd, A. M. M., and Stevenson, I. H., 1975, The effect of age on the sensitivity to warfarin sodium, Br. J. Clin. Pharmacol. 2:189P–190P.

    CAS  Google Scholar 

  • Hines, J. D., and Love, D., 1975, Abnormal vitamin B-6 metabolism in sideroblastic anemia: Effect of pyridoxal phosphate therapy, Clin. Res. 23:403A.

    Google Scholar 

  • Hitzhuzen, J. C., Taplin, M. E., Stephenson, W. P., and Ansell, J. E., 1986, Vitamin B-12 levels and age, Am. J. Clin. Pathol. 85:32–36.

    Google Scholar 

  • Hogenkamp, H. P. C., 1980, The interaction between vitamin B-12 and vitamin C., Am. J. Clin. Nutr. 33:1–3.

    CAS  Google Scholar 

  • Holick, M. F., and Clark, M. B., 1978, The photobiogenesis and metabolism of vitamin D, Fed. Proc. 37:2567–2574.

    CAS  Google Scholar 

  • Holick, M. F., and Potts, J. T., Jr., 1983, Vitamin D, in: Harrison’s Principles of Internal Medicine (R. G. Petersdorf, R. D. Adams, E. Braunwald, K. J. Isselbacher, J. B. Martin, and J. D. Wilson, eds.), McGraw-Hill, New York, pp. 1944–1949.

    Google Scholar 

  • Hollander, D., and Morgan, D., 1979, Aging: Its influence on vitamin A intestinal absorption in vivo by the rat, Esp. Gerontol. 14:301–305.

    CAS  Google Scholar 

  • Hollander, D., and Tarnawski, H., 1984, Influence of aging on vitamin D absorption and unstirred water layer dimensions in the rat, J. Lab. Clin. Med. 103:462–469.

    CAS  Google Scholar 

  • Holloway, D. E., and Peterson, F. J., 1984, Ascorbic acid in drug metabolism, in: Drugs and Nutrients: The Interaction Effects (D. A. Roe and T. C. Campbell, eds.), Marcel Dekker, New York, Basel, pp. 225–295.

    Google Scholar 

  • Holt, P. R., and Dominguez, A. A., 1981, Intestinal absorption of triglyceride and vitamin D3 in aged and young rats, Dig. Dis. Sci. 26:1109–1115.

    Article  CAS  Google Scholar 

  • Hoorn, R. K. J., Flikweert, J. P., and Westerink, D., 1975, Vitamin B-l, B-2 and B-6 deficiencies in geriatric patients, measured by coenzyme stimulation of enzyme activities, Clin. Chim. Acta 61:151–162.

    Article  CAS  Google Scholar 

  • Hoppner, K., and Lampi, B., 1980, Folate levels in human liver from autopsies in Canada, Am. J. Clin. Nutr. 33:862–864.

    CAS  Google Scholar 

  • Hoppner, K., Phillips, W. E. J., Murray, T. K., and Campbell, J. S., 1968, Survey of liver vitamin A stores of Canadians, Can. Med. Assoc. J. 99:983–986.

    CAS  Google Scholar 

  • Horwitt, M. K., Harvey, C. C., Dahm, C. J., Jr., and Searey, M. T., 1972, Relationship between tocopherol and serum lipid levels for determination of nutritional adequacy, Ann. N.Y. Acad. Sci. 203:223–236.

    Article  CAS  Google Scholar 

  • Houston, J. B., and Levy, G., 1975, Modification of drug biotransformation by vitamin C in man, Nature 255:78–79.

    Article  CAS  Google Scholar 

  • Hoyumpa, A. M., Jr., Breen, K. J., Schenker, S., and Wilson, F. A., 1975, Thiamine transport across the rat intestine. II. Effects of ethanol, J. Lab. Clin. Med. 86:803–816.

    CAS  Google Scholar 

  • Hradsky, M., Groh, J., Langer, F., and Herout, V., 1966, Chronische gastritis bei jungen und alten personen, histologische und histochemische Untersuchung, Gerontol. Clin. 8:164–171.

    Article  CAS  Google Scholar 

  • Hsu, J. M., Kawin, B., Minor, P., and Mitchell, J. A., 1966, Vitamin B-12 concentrations in human tissues, Nature 210:1264–1265.

    Article  CAS  Google Scholar 

  • Hurdle, A. D. F., and Williams, T. C. P., 1966, Folie acid deficiency in elderly patients admitted to hospital, Br. Med. J. 2:202–205.

    Article  CAS  Google Scholar 

  • Hyams, D. E., 1964, The absorption of vitamin B-12 in the elderly, Gerontol. Clin. 6:193–206.

    Article  Google Scholar 

  • Iber, F. L., Blass, J. P., Brin, M., and Leevy, C. M., 1982, Thiamin in the elderly—relation to alcoholism and to neurological degenerative disease, Am. J. Clin. Nutr. 36:1067–1082.

    CAS  Google Scholar 

  • Immerman, A. M., 1981, Vitamin B-12 status on a vegetarian diet, World Rev. Nutr. Diet. 37:38–54.

    CAS  Google Scholar 

  • Ishiguro, K., 1961, Pantothenic acid and age, Tohoku J. Exp. Med. 75:137–150.

    Article  CAS  Google Scholar 

  • Ishiguro, K., 1972, Aging effect of blood pantothenic acid content in female, Tohoku J. Exp. Med. 107:367–372.

    Article  CAS  Google Scholar 

  • Ishiguro, K., Kobayashi, S., and Kaneta, S., 1961, Pantothenic acid content of human blood, Tohoku J. Exp. Med. 74:65–68.

    Article  CAS  Google Scholar 

  • Jacob, R. A., Otradovec, C. L., Russell, R. M., Munro, H. N., Hartz, S. C., McGandy, R. B., Morrow, F. D., and Sadowski, J. A., 1988, Vitamin C status and nutrient interactions in a health population, Am. J. Clin. Nutr. (in press).

    Google Scholar 

  • Jacobs, A., Cavill, I. A. J., and Hughes, J. N. P., 1968, Erythrocyte transaminase activity. Effect of age, sex, and vitamin B-6 supplementation, Am. J. Clin. Nutr. 21:502–507.

    CAS  Google Scholar 

  • Jaffe, G. M., 1984, Vitamin C., in: Handbook of Vitamins: Nutritional, Biochemical and Clinical Aspects (L. J. Machlin, ed.), Marcel Dekker, New York, pp. 199–244.

    Google Scholar 

  • Jagerstad, M., and Westesson, A. K., 1979, Folate, Scand. J. Gastroenterol. 14:(Suppl 52): 196–202.

    CAS  Google Scholar 

  • Kark, R., and Lozner, E. L., 1939, Nutritional deficiency of vitamin K in man, Lancet 2:1162–1164.

    Article  Google Scholar 

  • Kataria, M. S., Rao, D. B., and Curtis, R. C., 1965, Vitamin C levels in the elderly, Gerontol. Clin. 7:189–190.

    Article  Google Scholar 

  • Kelleher, J., and Losowsky, M. S., 1978, Vitamin E in the elderly, in: Tocopherol, Oxygen and Biomembranes (C. de Duve and O. Hayaishi, eds.), Elsevier/North Holland Biomedical Press, Amsterdam, pp. 311–327.

    Google Scholar 

  • Kesavan, V., and Noronha, J. M., 1983, Folate malabsorption in aged rats related to low levels of pancreatic folyl conjugase, Am. J. Clin. Nutr. 37:262–267.

    CAS  Google Scholar 

  • Kheim, T., and Kirk, J. E., 1967, Vitamin B-6 content of human arterial and venous tissue, Am. J. Clin. Nutr. 20:702–707.

    CAS  Google Scholar 

  • Killander, A., 1957, The serum vitamin B-12 levels at various ages, Acta Paediatr. 46:585–594.

    Article  CAS  Google Scholar 

  • Kilpatrick, G. S., and Withey, J. L., 1965, The serum vitamin B-12 concentration in the general population, Scand. J. Haematol. 2:220–229.

    Article  CAS  Google Scholar 

  • King, C. E., Leibach, J., and Toskes, P. P., 1979, Clinically significant vitamin B-12 deficiency secondary to malabsorption of protein-bound vitamin B-12, Dig. Dis. Sci. 24:397–402.

    Article  CAS  Google Scholar 

  • Kirk, E., and Chieffi, M., 1948, Vitamin studies in middle-aged and old individuals. I. The vitamin A, total carotene and alpha + beta carotene concentration in plasma, J. Nutr. 36:315–322.

    CAS  Google Scholar 

  • Kirk, J. E., and Chieffi, M., 1951, Effect of oral thiamine administration on thiamine content of the stool, Proc. Soc. Exp. Biol. Med. 77:464–466.

    Article  CAS  Google Scholar 

  • Kirk, J. E., and Chieffi, M., 1953a, Vitamin studies in middle-aged and old individuals. XI. The concentration of total ascorbic acid in whole blood, J. Gerontol. 8:301–304.

    Article  CAS  Google Scholar 

  • Kirk, J. E., and Chieffi, M., 1953b, Vitamin studies in middle-aged and old individuals. XII. Hypovitaminemia C., J. Gerontol. 8:305–311.

    Article  CAS  Google Scholar 

  • Kistler, L. A., and Giannella, R. A., 1980, Relationship of intestinal bacteria to malabsorption, Prac. Gastroenterol. 4:24–44.

    Google Scholar 

  • Kohrs, M. B., O’Neal, R., Preston, A., Eklund, D., and Abrahams, O., 1978, Nutritional status of elderly residents in Missouri, Am. J. Clin. Nutr. 31:2186–2197.

    CAS  Google Scholar 

  • Krasinski, S., Russell, R. M., Samloff, I. M., Jacob, R. A., Dallai, G. E., McGandy, R. B., and Hartz, S. C., 1983, Prevalence and severity of atrophic gastritis in an elderly population: Effect on serum status of certain nutrients, Gastroenterology 84:1291.

    Google Scholar 

  • Krasinski, S. D., Russell, R. M., Dallai, G. E., and Dutta, S. K., 1985a, Aging changes vitamin A absorption characteristics, Gastroenterology 88:1715.

    Google Scholar 

  • Krasinski, S. D., Russell, R. M., Furie, B. C., Kruger, S. F., Jacques, P. F., and Furie, B., 1985b, The prevalence of vitamin K deficiency in chronic gastrointestinal disorders, Am. J. Clin. Nutr. 41:639–643.

    CAS  Google Scholar 

  • Krawitt, E. L., and Chastenay, B. F., 1980, 25-Hydroxy vitamin D absorption test in patients with gastrointestinal disorders, Calcif. Tissue Int. 32:183–187.

    Article  CAS  Google Scholar 

  • Kreuning, J., Bosman, F. T., Kuiper, G., Wal, A. M., and Lindeman, J., 1978, Gastric and duodenal mucosa in healthy individuals, J. Clin. Pathol. 31:69–77.

    Article  CAS  Google Scholar 

  • Kushner, J. P., and Cartwright, G. E., 1977, Sideroblastic anemia, Adv. Intern. Med. 22:229–249.

    CAS  Google Scholar 

  • Lambert-Allardt, C., 1984, The relationship between serum 25-hydroxy-vitamin D levels and other variables related to calcium and phosphorus metabolism in the elderly, Acta Endocrinol. 105:139–144.

    Google Scholar 

  • Lawrence, V. A., 1983, Demographic analysis of serum folate and folate binding capacity in hospitalized patients, Acta Haematol. 69:289–293.

    Article  CAS  Google Scholar 

  • Lawson, D. E. M., Paul, A. A., Black, A. E., Cole, T. J., Mandai, A. R., and Davie, M., 1979, Relative contributions of diet and sunlight to vitamin D state in the elderly, Br. Med. J. 2:303–305.

    Article  CAS  Google Scholar 

  • Ledvina, M., 1985, Vitamin E in the aged, in: CRC Handbook of Nutrition in the Aged (R. R. Watson, ed.), CRC Press, Boca Raton, FL, pp. 89–109.

    Google Scholar 

  • Leevy, C. M., 1982, Thiamin deficiency and alcoholism, Ann. N.Y. Acad. Sci. 378:316–326.

    Article  CAS  Google Scholar 

  • Leichter, J., Angel, J. F., and Lee, M., 1978, Nutritional status of a select group of free-living elderly people in Vancouver, Can. Med. Assoc. J. 118:40–43.

    CAS  Google Scholar 

  • Leinert, J., Simon, I., and Hotzel, D., 1983, Methoden und deren wertung zur bestimmung des vitamin B-6 versorgungszustandes beim menschen, Int. J. Vitam. Nutr. Res. 53:166–178.

    CAS  Google Scholar 

  • Leitner, Z. A., Moore, T., and Sharman, I. M., 1960, Vitamin A and vitamin E in human blood, Br. J. Nutr. 14:281–287.

    Article  CAS  Google Scholar 

  • Leklem, J. E., Shultz, T. D., and Miller, L. T., 1980, Comparative bioavailability of vitamin B-6 from soybeans and beef, Fed. Proc. 39:558.

    Google Scholar 

  • Leo, M. A., Lowe, N., and Lieber, C. S., 1982, Decreased hepatic vitamin A after drug administration in men and rats, Hepatology 2:679.

    Google Scholar 

  • Leo, M. A., Lowe, N., and Lieber, C. S., 1984, Decreased hepatic vitamin A after drug administration in men and in rats, Am. J. Clin. Nutr. 40:1131–1136.

    Google Scholar 

  • Leonhardt, E. T. G., 1978, Effects of vitamin E on serum cholesterol and triglycerides in hyperlipidemic patients treated with diet and clofibrate, Am. J. Clin. Nutr. 31:100–105.

    CAS  Google Scholar 

  • Lester, E., Skinner, R. K., and Wills, M. R., 1977, Seasonal variation in serum-25-hydroxyvitamin-D in the elderly in Britain, Lancet 1:979–980.

    Article  CAS  Google Scholar 

  • Lewis, J. S., Pian, A. K., Baer, M. T., Acosta, P. B., and Emerson, G. A., 1973, Effect of long-term ingestion of polyunsaturated fat, age, plasma cholesterol, diabetes mellitus, and supplemental tocopherol upon plasma tocopherol, Am. J. Clin. Nutr. 26:136–143.

    CAS  Google Scholar 

  • Lindberg, A. S., Leklem, J. E., and Miller, L. T., 1983, The effect of wheat bran on the bioavailability of vitamin B-6 in young men, J. Nutr. 113:2578–2586.

    CAS  Google Scholar 

  • Lindenbaum, J., and Lieber, C. S., 1969, Alcohol-induced malabsorption of vitamin B-12 in man, Nature 224:806.

    Article  CAS  Google Scholar 

  • Lips, P., Jongen, M. J. M., van Ginkel, F. C., Netelenbos, J. C., and van der Vijgh, W. J. F., 1985, Determinants of vitamin D status in the elderly, in: Vitamin D. A Chemical, Biochemical and Clinical Update (A. W. Norman, K. Schaefer, H. G. Grigoleit, and D. V. Herrath, eds.), Walter de Gruyter & Co., Berlin, New York, pp. 1020–1021.

    Google Scholar 

  • Loh, H. S., 1972, The relationship between dietary ascorbic acid intake and buffy coat and plasma ascorbic acid concentrations at different ages, Int. J. Vitam. Nutr. Res. 42:80–85.

    CAS  Google Scholar 

  • Loh, H. S., and Wilson, C. W. M., 1971, The relationship between leucocyte ascorbic acid and haemoglobin levels at different ages, Int. J. Vitam. Nutr. Res. 41:259–267.

    CAS  Google Scholar 

  • Lonergan, M. E., Milne, J. S., Maule, M. M., and Williamson, J., 1975, A dietary survey of older people in Edinburgh, Br. J. Nutr. 34:517–527.

    CAS  Google Scholar 

  • Lopez, R., Fisher, L. V., and Cooperman, J. M., 1979, Riboflavin deficiency in an aged population, Fed. Proc. 38:451.

    Google Scholar 

  • Lowenstein, F. W., 1982, Nutritional status of the elderly in the United States of America, 1971-1974, J. Am. Coll. Nutr. 1:165–177.

    CAS  Google Scholar 

  • Lumeng, L., and Li, T. K., 1974, Vitamin B-6 metabolism in chronic alcohol abuse, J. Clin. Invest. 53:693–704.

    Article  CAS  Google Scholar 

  • Lund, B., and Sorensen, O. H., 1979, Measurement of 25-hydroxyvitamin D in serum and its relation to sunshine, age and vitamin D intake in the Danish population, Scand. J. Clin. Lab. Invest. 39:23–30.

    Article  CAS  Google Scholar 

  • Machlin, L. J. (ed), 1984a, Handbook of Vitamins: Nutritional, Biochemical, and Clinical Aspects, Marcel Dekker, New York.

    Google Scholar 

  • Machlin, L. J., 1984b, Vitamin E, in: Handbook of Vitamins: Nutritional, Biochemical, and Clinical Aspects (L. J. Machlin, ed.), Marcel Dekker, New York, pp. 99–146.

    Google Scholar 

  • MacLaughlin, J., and Holick, M. F., 1985, Aging significantly decreases the capacity of human skin to produce vitamin D3, J. Clin. Invest. 76:1536–1538.

    Article  CAS  Google Scholar 

  • MacLennan, W. J., and Hamilton, J. C., 1979, Plasma binding capacity for 25-hydroxy-vitamin D in the elderly, J. Clin. Pathol. 32:240–243.

    Article  CAS  Google Scholar 

  • MacLeod, C. C., Judge, T. G., and Caird, F. I., 1974, Nutrition of the elderly at home. II. Intakes of vitamins, Age Aging 3:209–220.

    Article  CAS  Google Scholar 

  • Magnus, E. M., Bache-Wiig, J. E., Anderson, T. R., and Melbostad, E., 1982, Folate and vitamin B-12 (cobalamin) blood levels in elderly persons in geriatric homes, Scand. J. Haematol. 28:360–366.

    Article  CAS  Google Scholar 

  • Majumdar, S. K., Shaw, G. K., and Thomson, A. D., 1983, Vitamin A utilization status in chronic alcoholic patients, Int. J. Vitam. Nutr. Res. 53:273–279.

    CAS  Google Scholar 

  • Markkanen, T., and Mustakallio, E., 1963, Absorption and excretion of biotin after feeding minced liver in achlorhydria and after partial gastrectomy, Scand. J. Clin. Lab. Invest. 15:57–61.

    Article  Google Scholar 

  • Markkanen, T., Heikinheimo, R., and Dahl, M., 1969, Transketolase activity of red blood cells from infancy to old age, Acta Haematol. 42:148–153.

    Article  CAS  Google Scholar 

  • Martin, P. R., Majchrowicz, E., Tamborska, E., Marietta, C., Mukherjee, A. B., and Eckardt, M. J., 1985, Response to ethanol reduced by past thiamine deficiency, Science 227:1365–1368.

    Article  CAS  Google Scholar 

  • Mason, D. Y., and Emerson, P. M., 1973, Primary acquired sideroblastic anemia: Response to treatment with pyridoxal-5-phosphate, Br. Med. J. 1:389–390.

    Article  CAS  Google Scholar 

  • Mawer, E. B., Backhouse, J., Hill, L. F., Lumb, G. A., De Silva, P., Taylor, C. M., and Stanbury, S. W., 1975, Vitamin D metabolism and parathyroid function in man, Clin. Sci. Mol. Med. 48:349–365.

    CAS  Google Scholar 

  • McEvoy, A. W., Fenwick, J. D., Boddy, K., and James, O. F. W., 1982, Vitamin B12 absorption from the gut does not decline with age in normal elderly humans, Age Aging 11:180–183.

    Article  CAS  Google Scholar 

  • McGandy, R. B., Russell, R. M., Hartz, S. C., Jacob, R. A., Tannenbaum, S., Peters, H., Sahyoun, N., and Otradovec, C. L., 1986, Nutritional status survey of healthy, non-institutionalized elderly: Nutrient intakes from 3-day diet records and nutrient supplements, Nutr. Res. 6:785–798.

    Article  Google Scholar 

  • McLaren, D. S., 1981, The luxus vitamins A and B-12, Am. J. Clin. Nutr. 34:1611–1616.

    CAS  Google Scholar 

  • Miller, L. T., Lindberg, A. S., Whanger, P., and Leklem, J. E., 1979, Effect of wheat bran on the bioavailability of vitamin B-6 and the excretion of selenium in men, Fed. Proc. 38:767.

    Google Scholar 

  • Milne, J. S., Lonergan, M. E., Williamson, J., Moore, F. M. L., McMaster, R., and Percy, N., 1971, Leucocyte ascorbic acid levels and vitamin C intake in older people, Br. Med. J. 4:383–386.

    Article  CAS  Google Scholar 

  • Miranda, C. L., Mukhtar, H., Bend, J. R., and Chhabra, R. S., 1979, Effects of vitamin A deficiency on hepatic and extrahepatic mixed-function oxidase and epoxide-metabolizing enzymes in guinea pig and rabbit, Biochem. Pharmacol. 28:2713–2716.

    Article  CAS  Google Scholar 

  • Mollin, D. L., and Ross, G. I. M., 1952, The vitamin B-12 concentration of serum and urine of normals and of patients with megaloblastic anemias and other diseases, J. Clin. Pathol. 5:129–139.

    Article  CAS  Google Scholar 

  • Morgan, A. F., Gillum, H. L., and Williams, R. I., 1955, Nutritional status of the aging: III. Serum ascorbic acid and intake, J. Nutr. 55:431–448.

    CAS  Google Scholar 

  • Morgan, A. G., Kelleher, J., Walker, B. E., Losowsky, M. S., Droller, H., and Middleton, R. S. W., 1973, A nutritional survey in the elderly: Haematological aspects, Int. J. Vitam. Nutr. Res. 43:461–471.

    CAS  Google Scholar 

  • Morgan, A. G., Kelleher, J., Walker, B. E., Losowsky, M. S., Droller, H., and Middleton, R. S. W., 1975, A nutritional survey in the elderly: Blood and urine vitamin levels, Int. J. Vitam. Nutr. Res. 45:448–462.

    CAS  Google Scholar 

  • Munro, H. N., McGandy, R. B., Hartz, S. C., Russell, R. M., Jacob, R. A., and Otradovec, C. L., 1987, Protein nutriture of a group of free-living elderly, Am. J. Clin. Nutr. 46:586–592.

    CAS  Google Scholar 

  • Muralidhara, K. S., and Hollander, D., 1977, Intestinal absorption of alpha-tocopherol in the unanesthetized rat. The influence of luminal constituents on the absorptive process, J. Lab. Clin. Med. 90:85–91.

    CAS  Google Scholar 

  • National Academy of Sciences, 1980, Recommended Dietary Allowances, 9th ed., National Academy Press, Washington.

    Google Scholar 

  • Nayal, A. S., MacLennan, W. J., Hamilton, J. C., Rose, P., and Kong, M., 1978, 25-Hydroxy-vitamin D, diet and sunlight exposure in patients admitted to a geriatric unit, Gerontology 24:117–122.

    Article  CAS  Google Scholar 

  • Newton, H. M. V., Sheltawy, M., Hay, A. W. M., and Morgan, B., 1985, The relations between vitamin D2 and D3 in the diet and plasma 25(OH)D2 and 25(OH)D3 in elderly women in Great Britain, Am. J. Clin. Nutr. 41:760–764.

    CAS  Google Scholar 

  • Nielson, B., 1965, The blood vitamin B-12 concentration of older patients admitted to a neurological department, Acta Neurol. Scand. 41:513–526.

    Article  Google Scholar 

  • Nyberg, W., Erikson, A., Forsius, H., and Fellman, J., 1964, Serum vitamin B-12 levels in an isolated island population, Acta Med. Scand. [Suppl.] 412:79–82.

    Google Scholar 

  • O’Hanlon, P., and Kohrs, M. B., 1978, Dietary studies of older Americans, Am. J. Clin. Nutr. 31:1257–1269.

    Google Scholar 

  • Olson, J. A., 1984a, Vitamin A, in: Handbook of Vitamins: Nutritional, Biochemical, and Clinical Aspects (L. J. Machlin, ed.), Marcel Dekker, New York, pp. 1–44.

    Google Scholar 

  • Olson, J. A., 1984b, Serum levels of vitamin A and carotenoids as reflectors of nutritional status, J. Natl. Cancer Inst. 73:1439–1444.

    CAS  Google Scholar 

  • Omdahl, J. L., Garry, P. J., Hunsaker, L. A., Hunt, W. C., and Goodwin, J. S., 1982, Nutritional status in a healthy elderly population: Vitamin D, Am. J. Clin. Nutr. 36:1225–1333.

    CAS  Google Scholar 

  • O’Sullivan, D. J., Callaghan, N., Ferriss, J. B., Finucane, J. F., and Hegarty, M., 1986, Ascorbic acid deficiency in the elderly, Irish J. Med. Sci. 1:151–156.

    Article  Google Scholar 

  • Parfitt, A. M., Gallagher, J. C., Heaney, R. P., Johnston, C. C., Neer, R., and Whedon, G. D., 1982, Vitamin D and bone health in the elderly, Am. J. Clin. Nutr. 36:1014–1031.

    CAS  Google Scholar 

  • Passeri, M., and Proveddini, D., 1982, La vitamina E nella fisiopathologia geriatrica, Acta Vitam. Enzymol. 5:53–63.

    Google Scholar 

  • Patnaik, B. K., and Kanungo, M. S., 1966, Ascorbic acid and aging in the rat, Biochem. J. 100:59–62.

    CAS  Google Scholar 

  • Pelletier, O., 1975, Vitamin C and cigarette smokers, Ann. N.Y. Acad. Sci. 258:156–168.

    CAS  Google Scholar 

  • Peterson, F. J., Holloway, D. E., Duquette, P. H., and Rivers, J. M., 1983, Dietary ascorbic acid and hepatic mixed function oxidase activity in the guinea pig, Biochem. Pharmacol. 32:91–96.

    Article  CAS  Google Scholar 

  • Peto, R., Doll, R., Buckley, J. D., and Sporn, M. B., 1981, Can dietary beta-carotene materially reduce human cancer rates? Nature 290:201–208.

    Article  CAS  Google Scholar 

  • Phillips, W. E. J., and Brien, R. L., 1970, Effect of pectin, a hypocholesterolemic polysaccharide, on vitamin A utilization in the rat, J. Nutr. 100:289–292.

    CAS  Google Scholar 

  • Pittet, P. G., Davie, M., and Lawson, D. E. M., 1979, Role of nutrition in the development of osteomalacia in the elderly, Nutr. Metab. 23:109–116.

    Article  CAS  Google Scholar 

  • Plough, I. C., 1960, The human requirement for vitamin B-6, Fed. Proc. 19:162.

    Google Scholar 

  • Prothro, J., Mickles, M., and Tolbert, B., 1976, Nutritional status of a population sample in Macon County, Alabama, Am. J. Clin. Nutr. 29:94–104.

    CAS  Google Scholar 

  • Rafsky, H. A., and Newman, B., 1943, Vitamin B-l excretion in the aged, Gastroenterology 1:737–742.

    CAS  Google Scholar 

  • Rafsky, H. A., Newman, B., and Jolliffe, N., 1947, The relationship of gastric acidity to thiamine excretion in the aged, J. Lab. Clin. Med. 32:118–123.

    CAS  Google Scholar 

  • Rafsky, H. A., Newman, B., and Jolliffe, N., 1948, A study of the carotene and vitamin A levels in the aged, Gastroenterology 8:612–615.

    Google Scholar 

  • Raica, N., Jr., Scott, J., Lowry, L., and Sauberlich, H. E., 1972, Vitamin A concentration in human tissues collected from five areas in the United States, Am. J. Clin. Nutr. 25:291–296.

    Google Scholar 

  • Ranke, E., Tauber, S. A., Horonick, A., Ranke, B., Goodhart, R. S., and Chow, B. F., 1960, Vitamin B-6 deficiency in the aged, J. Gerontol. 15:41–44.

    Article  CAS  Google Scholar 

  • Rao, G. H., and Mason, K. E., 1975, Antisterility and antivitamin K activity of d-alpha-tocopheryl hydroquinone in the vitamin E-deficient female rat, J. Nutr. 105:495–498.

    CAS  Google Scholar 

  • Ristow, K. A., Gregory, J. F., and Damron, B. L., 1982, Effects of dietary fiber on the bioavailability of folic acid monoglutamate, J. Nutr. 112:750–758.

    CAS  Google Scholar 

  • Roderuck, C., Burrill, L., Campbell, L. J., Brakke, B. E., Childs, M. T., Leverton, X. R., Chaloupka, M., Jebe, E. H., and Swanson, P. P., 1958, Estimated dietary intake, urinary excretion and blood vitamin C in women of different ages, J. Nutr. 66:15–27.

    CAS  Google Scholar 

  • Rodriguez, M. S., 1978, A conspectus of research on folacin requirements of man, J. Nutr. 108:1983–2103.

    CAS  Google Scholar 

  • Roe, D. A., Wrick, K., McLain, D., and van Soest, P., 1978, Effects of dietary fiber sources on riboflavin absorption, Fed. Proc. 37:756.

    Google Scholar 

  • Roine, P., Koivula, L., Pekkarinen, M., and Rissanen, A., 1974, Vitamin C intake and plasma level among aged people in Finland, Int. J. Vitam. Nutr. Res. 44:95–106.

    CAS  Google Scholar 

  • Rose, C. S., Gyorgy, P., Butler, M., Andres, R., Norris, A. H., Shock, N. W., Tobin, J., Brin, M., and Spiegel, H., 1976, Age differences in vitamin B-6 status of 617 men, Am. J. Clin. Nutr. 29:847–853.

    CAS  Google Scholar 

  • Rosenberg, I. H., 1981, Intestinal absorption of folate, in: Physiology of the Gastrointestinal Tract (L. R. Johnson, ed.), Raven Press, New York, pp. 1221–1230.

    Google Scholar 

  • Rosenberg, I. H., Selhub, J., and Dhar, G. J., 1979, Absorption and malabsorption of folates, in: Folic Acid in Neurology, Psychiatry, and Internal Medicine (M. I. Botez and E. H. Reynolds, eds.), Raven Press, New York, pp. 95–111.

    Google Scholar 

  • Rosenberg, I. H., Bowman, B. B., Cooper, B. A., Halstead, C. H., and Lindenbaum, J., 1982, Folate nutrition in the elderly, Am. J. Clin. Nutr. 36:1060–1066.

    CAS  Google Scholar 

  • Roth, K. S., 1981, Biotin in clinical medicine—a review, Am. J. Clin. Nutr. 34:1967–1974.

    CAS  Google Scholar 

  • Runcie, J., 1979, Folate deficiency in the elderly, in: Folic acid in Neurology, Psychiatry, and Internal Medicine (M. I. Botez and E. H. Reynolds, eds.), Raven Press, New York, pp. 493–499.

    Google Scholar 

  • Rushton, C., 1978, Vitamin D hydroxylation in youth and old age, Age Aging 7:91–95.

    Article  CAS  Google Scholar 

  • Russell, R. M., Ismail-Beigi, F., and Reinhold, J. G., 1976, Folate content of Iranian breads and the effect of their fiber content on the intestinal absorption of folic acid, Am. J. Clin. Nutr. 29:799–802.

    CAS  Google Scholar 

  • Russell, R. M., Dhar, G. J., Dutta, S. K., and Rosenberg, I. H., 1979, Influence of intraluminal pH on folate absorption: Studies in control subjects and in patients with pancreatic insufficiency, J. Lab. Clin. Med. 93:428–436.

    CAS  Google Scholar 

  • Russell, R. M., Rosenberg, I. H., Wilson, P. D., Iber, F. L., Oaks, E. B., Giovetti, H. C., Otradovec, C. L., Karwoski, P. A., and Press, A. W., 1983, Increased urinary excretion and prolonged turnover time of folic acid during ethanol ingestion, Am. J. Clin. Nutr. 38:64–70.

    CAS  Google Scholar 

  • Russell, R. M., Goldner, B. B., and Krasinski, S. D., 1985, Impariment of folic acid absorption by postpranial antacid in elderly subjects, Gastroenterology 88:1563.

    Article  Google Scholar 

  • Russell, R. M., Krasinski, S. D., Samloff, I. M., Jacob, R. A., Hartz, S. C., and Brovender, S. R., 1986, Folic acid malabsorption in atrophic gastritis: Compensation by bacterial folate synthesis, Gastroenterology 91:1476–1483.

    CAS  Google Scholar 

  • Rutishauser, I. H. E., Bates, C. J., Paul, A. A., Black, A. E., Mandai, A. R., and Patnaik, B. K., 1979, Long-term status and dietary intake of healthy elderly subjects. 1. Riboflavin, Br. J. Nutr. 42:33–42.

    Article  CAS  Google Scholar 

  • Sahud, M. A., and Cohen, R. J., 1971, Effect of aspirin ingestion on ascorbic acid levels in rheumatoid arthritis, Lancet 1:937–938.

    Article  CAS  Google Scholar 

  • Said, H. M., and Hollander, D., 1985, Does aging effect the intestinal transport of riboflavin? Life Sci. 36:69–73.

    Article  CAS  Google Scholar 

  • Salkeld, R. M. and Stotz, R., 1985, Vitamin B-6 deficiency: An etiological factor of the carpal tunnel syndrome, in: Vitamin B-6: Its Role in Health and Disease (J. Leklem and B. Reynolds, eds.), Alan R. Liss, New York, pp. 463–467.

    Google Scholar 

  • Sato, M., and Lieber, C. S., 1981, Hepatic vitamin A depletion after chronic ethanol consumption in baboons and rats, J. Nutr. 111:2015–2023.

    CAS  Google Scholar 

  • Sauberlich, H. E., Herman, Y. F., Stevens, C. O., and Herman, R. H., 1979, Thiamin requirement of the adult human, Am. J. Clin. Nutr. 32:2237–2248.

    CAS  Google Scholar 

  • Sauberlich, H. E., Skala, H. J., and Dowdy, R. P., 1984, Laboratory Tests for the Assessment of Nutritional Status, CRC Press, Boca Raton, FL.

    Google Scholar 

  • Schaus, R., 1957, The ascorbic acid content of human pituitary, cerebral cortex, heart and skeletal muscle and its relation to age, Am. J. Clin. Nutr. 5:39–42.

    CAS  Google Scholar 

  • Schaus, R., and Kirk, J. E., 1957, The riboflavin concentration of brain, heart, and skeletal muscle in individuals of various ages, J. Gerontol. 11:147–150.

    Article  Google Scholar 

  • Schmidt, V., 1951, The excretion of pantothenic acid in the urine in young and old individuals, J. Gerontol. 6:132–134.

    Article  CAS  Google Scholar 

  • Schorah, C. J., 1979, An assessment of the prevalence and importance of vitamin C depletion in an urban population, Int. J. Vitam. Nutr. Res. 19:(Supp1):167–177.

    CAS  Google Scholar 

  • Schorah, C. J., Scott, D. L., Newill, A., and Morgan, D. B., 1979, Clinical effects of vitamin C in elderly inpatients with low blood vitamin C levels, Lancet 1:403–405.

    Article  CAS  Google Scholar 

  • Sedrani, S. H., Elidrissy, A. W. T. H., and El Arabi, K. M., 1983, Sunlight and vitamin D status in normal Saudi subjects, Am. J. Clin. Nutr. 38:129–132.

    CAS  Google Scholar 

  • Seetharam, B., and Alpers, D. H., 1985, Cellular uptake of cobalamin, Nutr. Rev. 43:97–102.

    Article  CAS  Google Scholar 

  • Sharpe, P. C., Mills, J. B., Horton, M. A., Hunt, R. H., Vincent, S. H., and Milton-Thomson, G. J., 1980, Histamine H-2 receptors and intrinsic factor secretion, Scand. J. Gastroenterol. 15:377–384.

    Article  CAS  Google Scholar 

  • Sheltawy, M., Newton, H., Hay, A., Morgan, D. B., and Hullin, R. P., 1984, The contribution of dietary vitamin D and sunlight to the plasma 25-hydroxyvitamin D in the elderly, Hum. Nutr. Clin. Nutr. 38C:191–194.

    Google Scholar 

  • Shepherd, A. M. M., Hewick, D. S., Moreland, T. A., and Stevenson, I. H., 1977, Age as a determinant of sensitivity to warfarin, Br. J. Clin. Pharmacol. 4:315–320.

    Article  CAS  Google Scholar 

  • Shideler, C. E., 1983, Vitamin B-6: An overview, Am. J. Med. Technol. 49:17–22.

    CAS  Google Scholar 

  • Skalka, H. W., and Prchal, J. T., 1981, Cataracts and riboflavin deficiency, Am. J. Clin. Nutr. 34:861–863.

    CAS  Google Scholar 

  • Schorah, C. J., Tormey, W. D., Brooks, G. H., Robertshaw, A., Young, G. A., Talukder, R., and Kelly, J. F., 1981, The effect of vitamin C supplements on body weight, serum proteins, and general health of the elderly, Am. J. Clin. Nutr. 34:871–876.

    CAS  Google Scholar 

  • Slovik, D. M., Adams, J. S., Neer, R. M., Holick, M. F., and Potts, J. T., Jr., 1981, Deficient production of 1,25-dihydroxyvitamin D in elderly osteoporotic patients, N. Engl. J. Med. 305:372–374.

    Article  CAS  Google Scholar 

  • Somerville, P. F., Lien, J. W. K., and Kaye, M., 1977, The calcium and vitamin D status in an elderly female population and their response to administered supplemental vitamin D3, J. Gerontol. 32:659–663.

    Article  CAS  Google Scholar 

  • Sowers, M. F. P., Wallace, R. B., Hollis, B. W., and Lemke, J. H., 1986, Parameters related to 25-OH-D levels in a population-based study of women, Am. J. Clin. Nutr. 43:621–628.

    CAS  Google Scholar 

  • Srinivasan, V., Christensen, N., Wyse, B.W., and Hansen, R. G., 1981, Pantothenic acid nutritional status in the elderly: Institutionalized and noninstitutionalized, Am. J. Clin. Nutr. 34:1736–1742.

    CAS  Google Scholar 

  • Stamp, T. C. B., and Round, J. M., 1974, Seasonal changes in human plasma levels of 25-hydroxyvitamin D, Nature 247:563–565.

    Article  CAS  Google Scholar 

  • Steinberg, W. M., King, C. E., and Toskes, P. P., 1980, Malabsorption of protein-bound cobalamin but not unbound cobalamin during cimetidine administration, Dig. Dis. Sci. 25:188–191.

    Article  CAS  Google Scholar 

  • Steinkamp, R. C., Cohen, N. L., and Walsh, H. E., 1965, Resurvey of an aging population—fourteen-year follow-up, J. Am. Diet. Assoc. 46:103–110.

    CAS  Google Scholar 

  • Stiedemann, M., Jansen, C., and Harrill, I., 1978, Nutritional status of elderly men and women, J. Am. Diet. Assoc. 73:132–139.

    CAS  Google Scholar 

  • Sugarman, B., and Munro, H. N., 1980, [14C]-Pantothenate accumulation by isolated adipocytes from adult rats of different ages, J. Nutr. 110:2297–2301.

    CAS  Google Scholar 

  • Suttie, J. W., 1984, Vitamin K, in: Handbook of Vitamins. Nutritional, Biochemical, and Clinical Aspects (J. L. Machlin, ed.), Marcel Dekker, New York, pp. 147–198.

    Google Scholar 

  • Suttie, J. W., and Jackson, C. M., 1977, Prothrombin structure, activation, and biosynthesis, Physiol. Rev. 57:1–70.

    CAS  Google Scholar 

  • Sweetman, L., Surh, L., Baker, H., Peterson, R. M., and Nyhan, W. L., 1981, Clinical and metabolic abnormalities in a boy with dietary deficiency of biotin, Pediatrics 68:553–558.

    CAS  Google Scholar 

  • Swendseid, M. E., Gasster, M., and Halsted, J. A., 1954, Absorption of vitamin B-12 in individuals with a functioning gastric mucosa, Fed. Proc. 13:308.

    Google Scholar 

  • TSNS, 1972, Ten-State Nutrition Survey, 1968-70, Part 5, Dietary, Center for Disease Control, Atlanta.

    Google Scholar 

  • Thackray, G. B., Sharman, I. M., and Hyams, D. E., 1972, Riboflavin status of the elderly, Proc. Nutr. Soc. 31:89A–90A.

    Google Scholar 

  • Thomson, A. D., 1966, Thiamine absorption in old age, Gerontol. Clin. 8:354–361.

    Article  Google Scholar 

  • Toss, G., Almqvist, S., Larsson, L., and Zetterqvist, H., 1980, Vitamin D deficiency in welfare institutions for the aged, Acta Med. Scand. 208:87–89.

    Article  CAS  Google Scholar 

  • Trimbo, S., Kathman, J., Kies, C., and Fox, H. M., 1979, Pantothenic acid nutritional status of adolescent humans as affected by dietary fiber and bran, Fed. Proc. 38:556.

    Google Scholar 

  • Tsai, K. S., Heath, H., Kumar, R., and Riggs, B. L., 1984, Impaired vitamin D metabolism with aging in women, J. Clin. Invest. 73:1668–1672.

    Article  CAS  Google Scholar 

  • Tulloch, J. A., and Sood, N. K., 1967, Vitamin E deficiency in Uganda, Am. J. Clin. Nutr. 20:884–887.

    CAS  Google Scholar 

  • Underwood, B. A., Siegel, H., Weisell, R. C., and Dolinski, M., 1970a, Liver stores of vitamin A in a normal population dying suddenly or rapidly from unnatural causes in New York City, Am. J. Clin. Nutr. 23:1037–1042.

    CAS  Google Scholar 

  • Underwood, B. A., Siegel, H., Dolinski, M., and Weisell, R. C., 1970b, Liver stores of alpha-tocopherol in a normal population dying suddenly and rapidly from unnatural causes in New York City, Am. J. Clin. Nutr. 23:1314–1321.

    CAS  Google Scholar 

  • United States Census of Population, 1980, Supplementary Reports: Age, Sex, Race and Spanish Origin of the Population by Regions, Divisions and States (PC80-S1-1), U.S. Government Printing Office, Washington.

    Google Scholar 

  • Vatassery, G. T., Alter, M., and Stadlan, E. M., 1971, Serum tocopherol levels and vibratory threshold changes with age, J. Gerontol. 26:481–484.

    Article  CAS  Google Scholar 

  • Vatassery, G. T., Johnson, G. J., and Krezowski, A. M., 1983, Changes in vitamin E concentrations in human plasma and platelets with age, J. Am. Coll. Nutr. 4:369–375.

    Google Scholar 

  • Vermeer, C., 1984, The vitamin K-dependent carboxylation reaction, Mol. Cell. Biochem. 61:17–35.

    Article  CAS  Google Scholar 

  • Vimokesant, S., Kunjara, S., Rungruangsak, K., Nakornchai, S., and Panijpan, B., 1982, Beriberi caused by antithiamin factors in food and its prevention, Ann. N.Y. Acad. Sci. 378:123–136.

    Article  CAS  Google Scholar 

  • Vir, S. C., and Love, A. H. G., 1977a, Nutritional evaluation of B group vitamins in institutionalised aged, Int. J. Vitam. Nutr. Res. 47:211–218.

    CAS  Google Scholar 

  • Vir, S. C., and Love, A. H. G., 1977b, Vitamin B-6 status of institutionalised and non-institutionalised aged, Int. J. Vitam. Nutr. Res. 47:364–372.

    CAS  Google Scholar 

  • Vir, S. C., and Love, A. H. G., 1977c, Thiamine status of institutionalised and non-institutionalised aged, Int. J. Vitam. Nutr. Res. 47:325–335.

    CAS  Google Scholar 

  • Vir, S. C., and Love, A. H. G., 1978a, Vitamin D status of elderly at home and institutionalised in hospital, Int. J. Vitam. Nutr. Res. 48:123–130.

    CAS  Google Scholar 

  • Vir, S. C., and Love, A. H. G., 1978b, Vitamin B-6 status of the hospitalized aged, Am. J. Clin. Nutr. 31:1383–1391.

    CAS  Google Scholar 

  • Vir, S. C., and Love, A. H. G., 1979, Nutritional status of institutionalised and non-institutionalised aged in Belfast, Northern Ireland, Am. J. Clin. Nutr. 32:1934–1947.

    CAS  Google Scholar 

  • Wagner, P. A., Bailey, L. B., Krista, M. L., Jernigan, J. A., Robinson, J. D., and Cerda, J. J., 1981, Comparison of zinc and folacin status in elderly women from differing socioeconomic backgrounds, Nutr. Res. 1:565–569.

    Article  CAS  Google Scholar 

  • Wald, G., 1968, Molecular basis of visual excitation, Science 162:230–235.

    Article  CAS  Google Scholar 

  • Walsh, J. H., Wyse, B. W., and Hansen, R. G., 1981, Pantothenic acid content of a nursing home diet, Ann. Nutr. Metab. 25:178–181.

    Article  CAS  Google Scholar 

  • Walsh, M. P., 1966, Determination of plasma pyridoxal phosphate with wheat germ glutamic-aspartic apotransaminase, Am. J. Clin. Pathol. 36:282–285.

    Google Scholar 

  • Watson, W. S., Vallance, B. D., Muir, M. M., and Hume, R., 1982, The effect of megadose ascorbic acid ingestion on the absorption and retention of vitamin B-12 in man, Scott. Med. J. 27:240–243.

    CAS  Google Scholar 

  • Webster, S. G. P., and Leeming, J. T., 1979, Erythrocyte folate levels in young and old, J. Am. Geriatr. Soc. 27:451–454.

    CAS  Google Scholar 

  • Weglicki, W. B., Luna, Z., and Nair, P. P., 1969, Sex and tissue specific differences in concentrations of alpha-tocopherol in mature and senescent rats, Nature 221:185–186.

    Article  CAS  Google Scholar 

  • Weisman, Y., Sehen, R. J., Eisenberg, Z., Edelstein, S., and Harell, A., 1981, Inadequate status and impaired metabolism of vitamin D in the elderly, Israel J. Med. Sci. 17:19–21.

    CAS  Google Scholar 

  • Weiss, P., and Bianchine, J. R., 1970, The effect of clofibrate of vitamin E concentrations in the rat, Atherosclerosis 11:203–205.

    Article  CAS  Google Scholar 

  • Wei-Wo, C. K., and Draper, H. H., 1975, Vitamin E status of Alaskan Eskimos, Am. J. Clin. Nutr. 28:808–813.

    CAS  Google Scholar 

  • Welkos, S. L., Toskes, P. P., Baer, H., and Smith, G. W., 1981, Importance of anaerobic bacteria in the cobalamin malabsorption of the experimental rat tlind loop syndrome, Gastroenterology 80:313–320.

    CAS  Google Scholar 

  • Willett, W. C., Polk, B. F., Underwood, B. A., Stampfer, M. J., Pressel, S., Rosner, B., Taylor, J. O., Schneider, K., and Hames, C. G., 1984, Relation of serum vitamins A and E and carotenoids to the risk of cancer, N. Engl. J. Med. 310:430–434.

    Article  CAS  Google Scholar 

  • Wolf, B., Heard, G. S., Jefferson, L. G., Proud, V. K., Nance, W. E., and Weissbecker, K. A., 1985, Clinical findings in four children with biotinidase deficiency detected through a statewide neonatal screening program, N. Engl. J. Med. 313:16–19.

    Article  CAS  Google Scholar 

  • Yamaguchi, D. M., Lipscomb, P. R., and Soule, E. H., 1965, Carpal tunnel syndrome, Minn. Med. 48:22–33.

    CAS  Google Scholar 

  • Yavorsky, M., Almaden, P., and King, C. G., 1934, The vitamin C content of human tissues, J. Biol. Chem. 106:525–529.

    CAS  Google Scholar 

  • Yearick, E. S., Wang, M. S. L., and Pisias, S. J., 1980, Nutritional status of the elderly: Dietary and biochemical findings, J. Gerontol. 35:663–671.

    Article  CAS  Google Scholar 

  • Yiengst, M. J., and Shock, N. W., 1949, Effect of oral administration of vitamin A on plasma levels of vitamin A and carotene in aged males, J. Gerontol. 4:205–211.

    Article  CAS  Google Scholar 

  • Ziemlanski, S., Wartanowicz, M., and Palaszewska, M., 1971, The effect of age and various diets on folic acid absorption in the alimentary tract, Acta Physiol. Pol. 22:241–246.

    CAS  Google Scholar 

  • Zimran, A., and Hershko, C., 1983, The changing pattern of megaloblastic anemia: Megaloblastic anemia in Israel, Am. J. Clin. Nutr. 37:855–861.

    CAS  Google Scholar 

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Authors and Affiliations

  1. USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, 02111, USA

    Paulo M. Suter & Robert M. Russell

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  1. Paulo M. Suter
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  2. Robert M. Russell
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  1. USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, 02111, USA

    Hamish N. Munro

  2. National Institutes of Health, Bethesda, Maryland, USA

    Darla E. Danford

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Suter, P.M., Russell, R.M. (1989). Vitamin Nutriture and Requirements of the Elderly. In: Munro, H.N., Danford, D.E. (eds) Nutrition, Aging, and the Elderly. Human Nutrition, vol 6. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2537-4_10

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  • DOI: https://doi.org/10.1007/978-1-4899-2537-4_10

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