Skip to main content

Infrared Imaging of Brain Function

  • Chapter

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 333))

Abstract

The aim of this article is to describe in detail a technique to record the thermal response of the animal brain cortex using an infrared (IR) optical system (Budko et al., 1985). We compare this method, which we call thermoencephaloscopy (TES), with other techniques for studying the cortex. Results obtained using TES are analyzed in relation to results from other neuromapping methods. Previous reports of our methodology were published primarily in Russian or in journals with limited circulation.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Almirall H., Broquetas A., Jofre L. (1991) Active microwave computed brain tomography: the response to a challenge. J Neurosci Methods 36: 239–251.

    Article  PubMed  CAS  Google Scholar 

  • Amber Engineering Inc. (1991) AE-4256 InSb IR Camera System. Catalog 1991.

    Google Scholar 

  • Baker M., Frye F., Millet V. (1973) Origin of temperature changes evoked in the brain by sensory stimulation. Exper Neurol 38: 502–519.

    Article  CAS  Google Scholar 

  • Baker M. (1982) Brain cooling in endotherms in heat and exercise. Ann Rev Physiol 44: 85–96.

    Article  CAS  Google Scholar 

  • Boppart S., Wheeler B., Wallace C. (1992) A flexible perforated microelectrode array for extended neural recordings. IEEE Trans Biomed Eng 39: 37–40.

    Article  PubMed  CAS  Google Scholar 

  • Budko K., Godik E., Gorbach A., Gulyaev Yu., Petrov A., Taratorin A., Tsicalov E., Shevelev I. (1985) Thermal responses of the brain to sensory stimulation. Doklady Biological Sciences March: 616-619.

    Google Scholar 

  • Cabanac M., and Brinnel H. (1985) Blood flow in emissary veins of the human head during hyperthermia. Eur J Appl Physiol 54: 172–176.

    Article  CAS  Google Scholar 

  • Cooper L., and Trezek G. (1972) A probe technique for determining the thermal conductivity of tissue. J Heat Transfer: 133-140.

    Google Scholar 

  • Cox S., Woolsey T., Rovainen C. (1991) Blood flow increases in rat barrel cortex during whisker stimulation. Soc Neurosci Abstr 17: 27.

    Google Scholar 

  • Delannoy J., Le Bihan D., Hoult D., Levin R. (1990) Hyperthermia system combined with a magnetic resonance imaging unit. Med Phys 17: 855–860.

    Article  PubMed  CAS  Google Scholar 

  • Duckrow R. (1991) Regional cerebral blood flow during spreading cortical depression in conscious rats. J Cereb Blood Flow Metab 11: 150–154.

    Article  PubMed  CAS  Google Scholar 

  • Falk D. (1990) Brain evolution in Homo: the “radiator” theory. Behav Brain Sci 13: 333–381.

    Article  Google Scholar 

  • Frolov A., Tsicalov E., Kiseleva N. (1985) Assessment of the characteristics of heat sources in the brain according to temperature distribution on the bone surface. in: The use of mathematical and computational methods in biology. Puschino, (in Russian): 132-133.

    Google Scholar 

  • George J., Lewine J., Moore S., Flynn E. (1991) IR thermal imaging of a monkey’s head: local temperature changes in response to somatosensory stimulation. Soc Neurosci Abstr 17: 475.

    Google Scholar 

  • Glossary of terms for thermal physiology (1987) Pflugers Arch 410: 567-587.

    Google Scholar 

  • Gorbach A., Tsicalov E., Kyznetsova G., Shevelev I., Budko K., Sharaev G. (1989a) Infrared mapping of the cerebral cortex, Thermology 3: 108–111.

    Google Scholar 

  • Gorbach A., Tsicalov E., Kyznetsova G., Shevelev I., Budko K., Sharaev G. (1989b) Infrared visualization of spreading wave processes in brain cortex. Abstr XVII Annual Meeting of the American Academy of Thermology: 2.20.

    Google Scholar 

  • Gorbach A., and Tsicalov E. (1990a) Thermoencephaloscopy-novel technology for research activation of cortex. The Physiologist 33: A–129.

    Google Scholar 

  • Gorbach A., and Tsicalov E. (1990b) Visualization of processes in the brain cortex: a new method. Proc XII Ann Conf IEEE Engin Med Biol Society 3/5: 1245–1246.

    Google Scholar 

  • Gorbach A., and Tsicalov E. (1991) Cortex activation during investigation of the associative learning. J Cereb Blood Flow Metab 11: S378.

    Google Scholar 

  • Grinvald A., Frostig R., Lieke E., Hildesheim R. (1988) Optical imaging of neuronal activity. Physiol Rev 68: 1285–1365.

    PubMed  CAS  Google Scholar 

  • Grayson J. (1952) Internal calorimetry in the determination of thermal conductivity and blood flow. J Physiol 118: 54–72.

    PubMed  CAS  Google Scholar 

  • Gulyaev Yu., Godik E., Petrov A, Taratorin A. (1985) Remote functional diagnosis of biological subjects by their intrinsic infrared radiation. Doklady Biophysics 277: 159–162.

    Google Scholar 

  • Gulyaev Yu., Godik E., Dementienko V., Kalashnikov I., Krasyuk N., Kuznetsov I. (1988) Radiothermal dynamic mapping of biological entities. Doklady Biophysics 299: 60–62.

    Google Scholar 

  • Hejazi S. (1990) A thermal imaging system based on multiwavelength infrared detection. Ph.D. Dissertation, SUNY at Buffalo, NY.

    Google Scholar 

  • Inframetrics, Inc. (1991) Inframetrics auxiliary optics for 500 & 600 series imaging radiometers. Catalog 1991.

    Google Scholar 

  • Ivanov K. (1990) “The principles of energetics in organism: theoretical and practical aspects,” Nauka, Leningrad (in Russian).

    Google Scholar 

  • Khizhnyak Ye., Bragin A, Ivanitskii G., Krinskii V., Tyazhelov V. (1986) Thermal activity of an isolated brain fragment. Biophysics 31: 971–983.

    Google Scholar 

  • Kondrashova M., Khizhniak E., Tiazhelov V. (1988) Heat production in mitochondria during oxidation of various substrates. Biofizika (in Russian) 33: 727–728.

    Google Scholar 

  • Koval’zon B., and Mukhametov L. (1983) Temperature fluctuations of the dolphin brain corresponding to unihemisperic slow-wave sleep. J Evol Biochem Physiol 18: 222–224.

    Google Scholar 

  • Kusano K., and Tasaki I. (1990) Heat generation associated with synaptic transmission in the mammalian superior cervical ganglion. J Neurosci Res 25: 249–255.

    Article  PubMed  CAS  Google Scholar 

  • Kuznetsova G., Nezlina N., Mutuskina E., Podolets A, Gurvich A. (1989a) Changes in the spreading depression wave in rats in the postresuscitation period. Fiziol J USSR (in Russian) 75: 1032–1037.

    CAS  Google Scholar 

  • Kuznetsova G., Nezlina N., Petrova E. (1989b) Thermovisualization of the hemisphere asymmetry in the animal brain. Doklady Biol Sci March: 623-627.

    Google Scholar 

  • LaManna J., McCracken K., Patil M., Prohaska O. (1989) Stimulus-activated changes in brain tissue temperature in anesthetized rat. Metab Brain Dis 4: 225–237.

    Article  PubMed  CAS  Google Scholar 

  • Le Bihan D., Delannoy J., Levin R. (1989) Non-invasive temperature mapping using magnetic resonance imaging of molecular diffusion: application to hyperthermia. Radiology 171: 853–857.

    PubMed  Google Scholar 

  • Lemons D., Chien S., Crawshaw L., Weinbaum S., Jiji L. (1987) Significance of vessel size and type in vascular heat transfer. Am J Physiol 253: R128–R135.

    PubMed  CAS  Google Scholar 

  • Lou H., Edvinsson L., MacKenzie E. (1987) The concept of coupling blood flow to brain function: revision required? Ann Neurol 22: 289–297.

    Article  PubMed  CAS  Google Scholar 

  • Madsen P., and Vorstrup S. (1991) Cerebral blood flow and metabolism during sleep. Cereb Brain Metabol Rev 3: 281–296.

    CAS  Google Scholar 

  • Maquet P., Dive D., Salmon E., Sadzot B., Franco G., Poirrier R., von Frenckel R., Franck G. (1990) Cerebral glucose utilization during sleep-wake cycle in man determined by positron emission tomography and [F]2-fluoro-2-deoxy-D-glucose method. Brain Res 513: 136–143.

    Article  PubMed  CAS  Google Scholar 

  • Melzack R., and Casey K. (1967) Localized temperature changes evoked in the brain by somatic stimulation. Exp Neurol 17: 293–312.

    Article  PubMed  Google Scholar 

  • McGinty D., and Szymusiak R. (1990) Keeping cool: a hypothesis about mechanisms and functions of slow-wave sleep. Trends Neurosci Meth 13: 480–487.

    Article  CAS  Google Scholar 

  • Meyer J., Amano T., Karacan I. (1981) Changes in LCBF measured by CT scan during REM and non-REM human sleep. J Cereb Blood Flow Metab Suppl 1: S465–466.

    Google Scholar 

  • Meyer J., Ishikawa Y., Hata T., Karacan I. (1987) Cerebral blood flow in normal and abnormal sleep and dreaming. Brain Cogn 6: 266–294.

    Article  PubMed  CAS  Google Scholar 

  • Mosso A. (1892) The temperature of the brain, especially in relation to psychical activity. Proc R Soc Lond 51: 83–85.

    Article  Google Scholar 

  • Mizushina S. (Ed.) (1989) “Non-invasive temperature measurement,” Gordon & Breach Sci Publ, New York.

    Google Scholar 

  • Nakashima M., Yamada S., Shinono S., Maeda M., Satoh F. (1992) 448-Detector optical recording system: development and application to Aplysia gill-withdrawal reflex. IEEE Trans Biomed Eng 39: 26–36.

    Article  PubMed  CAS  Google Scholar 

  • Neill K., Crain B., Nadler V. (1990) A simple, inexpensive method of monitoring brain temperature in conscious rodents. J of Neurosci Methods 33: 179–183.

    Article  CAS  Google Scholar 

  • Pasechnik V., and Kuznetsova G. (1987) Evolution of heat production induced by a wave of spreading depression. Biophysics 32: 155–160.

    Google Scholar 

  • Petrova E., and Markov A. (1989) Thermal asymmetry of the rat brain in catalepsy. Zhurnal Vysshei Nervnoi Deyatel’nosti imeni I. Pavlova (in Russian) 39: 1160–1162.

    CAS  Google Scholar 

  • Ramm P., and Frost B. (1983) Regional metabolic activity in the rat brain during sleep-wake activity. Sleep 6: 196–216.

    PubMed  CAS  Google Scholar 

  • Ratzlaff E., and Grinvald A. (1991) A tandem-lens epifluorescence macroscope: hundred-fold brightness advantage for wide-field imaging. J Neurosci Methods 36: 127–137.

    Article  PubMed  CAS  Google Scholar 

  • Ritchie J., and Keynes R. (1985) The production and absorption of heat associated with electrical activity in nerve and electric organ. Q Rev Biophys 18: 451–476.

    Article  PubMed  CAS  Google Scholar 

  • Roy C, and Sherrington C. (1890) On the regulation of the blood supply of the brain. J Physiol (London) 11: 85–108.

    CAS  Google Scholar 

  • Rusinov V., Tsykalov E., Kuznetsova G. (1990) Temperature reactions of the cerebral cortex in the rat and the distant effect of an experimentally evoked excitatory focus. Neurosci Behav Physiol 20: 167–173.

    Article  PubMed  CAS  Google Scholar 

  • Sawaya R., and Ingvar D. (1989) Cerebral blood flow and metabolism in sleep. Acta Neurol Scand 80: 481–491.

    Article  PubMed  CAS  Google Scholar 

  • Serota H., and Gerard R. (1938) Localized thermal changes in the cat’s brain. J Neurophysiol 1: 115–124.

    CAS  Google Scholar 

  • Sherebrin M. (1972) Changes in infrared spectrum of nerve during excitation. Nature New Biol 235: 122–124.

    PubMed  CAS  Google Scholar 

  • Shevelev I., Gorbach A., Tsicalov E., Budko K., Sharaev G. (1986a) Thermovisual study of reaction to light in the human brain. Doklady Biological Sciences 1-6: 644–647.

    Google Scholar 

  • Shevelev L, Kotlyar B., Volovik M., Martinson Yu., Budko K., Tsykalov E., Sharaev G., Gorbach A. (1986b) Detection of activation of the cat motor cortex during limb movement by thermomapping of the brain. Neirofiziologiya (in Russian) 18: 266–269.

    CAS  Google Scholar 

  • Shevelev I., Kuznetsova G., Gulyaev Yu., Godik E., Petrov A., Taratorin A., Tsicalov E., Koroleva V., Budko K., Gorbach A. (1986c) Dynamic thermal mapping of rat brain during sensory stimulation and spreading depression. Neurophysiology September: 18-25.

    Google Scholar 

  • Shevelev L, Tsicalov E., Gorbach A., Budko K., Sharaev G. (1986d) Thermovision parameters of brain responses to visual stimulation. Hum Physiol May: 227-232.

    Google Scholar 

  • Shevelev I., Tsicalov E., Gorbach A., Budko K., Sharaev G. (1986e) Thermoencephaloscopy. Human Physiology November: 1-8.

    Google Scholar 

  • Shevelev L, Tsicalov E., Budko K. Gorbach A., Sharaev G. (1986f) Spatial characteristics and dynamics of activation foci in the cortex during elaboration of a conditioned reflex (Thermographic Studies). Zhurnal Vysshei Nervnoi Deyatel’nosti imeni I.P.Pavlova (in Russian) 36: 74–83.

    CAS  Google Scholar 

  • Shevelev I., Tsicalov E., Volovik M., Budko K., Sharaev G., Gorbach A. (1986g) Sensory mapping of the cerebral cortex by thermovision methods in rats. J of Evol Biochem and Physiol 21: 348–355.

    Google Scholar 

  • Shevelev I., Tsykalov E., Budko K., Gorbach A., Sharaev G. (1987a) Movement of thermowaves over the cerebral cortex in the white rat. Neurophysiology January: 250-255.

    Google Scholar 

  • Shevelev I., Volovik M., Sharaev G., Tsykalov E., Budko K., Gorbach A. (1987b) Parameters of photic stimulation and characteristics of thermal response in the white rat cerebral cortex. Neurophysiology January: 243-249.

    Google Scholar 

  • Shevelev I., Tsicalov E., Gorbach A, Budko K., Sharaev G. (1988) Dynamic infrared images of the brain. IBRO NEWS 16: 8–9.

    Google Scholar 

  • Shevelev I., Kuznetsova G., Tsicalov E., Gorbach A., Budko K., Sharaev G. (1989a) “Thermoencephaloscopy” Nauka, Moscow (in Russian).

    Google Scholar 

  • Shevelev I., Tsicalov E., Gorbach A., Budko K., Sharaev G. (1989b) Spread of fast thermowaves through the cerebral cortex produced by visual stimulation. Neurophysiology March: 331-338.

    Google Scholar 

  • Shevelev I., Tsicalov E., Gorbach A, Budko K., Sharaev G. (1991a) Dynamic infrared functional mapping of the brain cortex. Biomed Sci 1: 571–577.

    Google Scholar 

  • Shevelev L, Tsicalov E., Gorbach A, Budko K., Sharaev G. (1991b) Dynamic functional mapping of the brain cortex by its infrared radiation, in: “Machinery of the Mind. Data, Theory, and Speculations About Higher Brain Function,” R. John, ed., Boston-Basel-Berlin, Birkhauser/Springer: 512–531.

    Google Scholar 

  • Shevelev I., Tsicalov E., Gorbach A, Budko K., Sharaev G. (1991c) Cortical processing: dynamic functional imaging by infrared radiation. Third IBRO World Congr Neurosci: 397.

    Google Scholar 

  • Shevelev I., Tsicalov E., Gorbach A., Budko K., Sharaev G. (1992) Thermoimaging of the brain. J Neurosci Methods, in press.

    Google Scholar 

  • Shevelev I., Kuznetsova G., Tsicalov E., Gorbach A., Sharaev G. (1993) Dynamic thermoimaging of the brain, (in preparation).

    Google Scholar 

  • Stolwijk J. (1970) Physiological and behavior temperature regulation. Heat Transfer in Medicine and Biology. New York: 703-745.

    Google Scholar 

  • Tasaki L, Byrne P., Masumura M. (1987) Detection of thermal responses of the retina by use of polyvinylidene fluoride multilayer detector. Jpn J Physiol 37: 609–619.

    Article  PubMed  CAS  Google Scholar 

  • Tasaki I., Kusano K., Byrne P. (1989) Rapid mechanical and thermal changes in the garfish olfactory nerve associated with a propagated impulse. Biophys J 55: 1033–1040.

    Article  PubMed  CAS  Google Scholar 

  • Tasaki I., and Byrne P. (1991) Demonstration of heat production associated with spreading depression in the amphibian retina. Biochemical and Biophys Research Communication 174: 293–297.

    Article  CAS  Google Scholar 

  • Toga A., ed. (1991) “Three-Dimensional Neuroimaging,” Raven Press, New York.

    Google Scholar 

  • Tsicalov E., Kuznetsova G., Shevelev I., Budko K., Gorbach A., Sharaev G. (1987) Thermal distribution over the cortical surface of the rat brain under direct electrical stimulation. Neurophysiology, November: 169-174.

    Google Scholar 

  • Tsicalov E., Petrov A., Taratorin A., Kuznetsova G., Koroleva V. (1985) Intrinsic temperature fields related to excitation of the rat cortex. Doclady Biological Sciences March: 613-616.

    Google Scholar 

  • Volovik M., Shevelev I., Vinogradova O., Bragin A., Podachin V., Lushchekina E., Ermakova L, Tsykalov E., Budko K., Gorbach A., Sharaev G. (1988) Thermovision control of neurotransplant in rats. Neurosci Behav Physiol 18: 492–497.

    Article  PubMed  CAS  Google Scholar 

  • Volovik M., Shevelev I., Tsykalov E., Sharaev G., Budko K., Gorbach A. (1990) Change in the configuration and localization of thermal foci in the cerebral cortex of the white rat during visual stimulation. Sensory Systems 3: 118–123.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1993 Springer Science+Business Media New York

About this chapter

Cite this chapter

Gorbach, A.M. (1993). Infrared Imaging of Brain Function. In: Dirnagl, U., Villringer, A., Einhäupl, K.M. (eds) Optical Imaging of Brain Function and Metabolism. Advances in Experimental Medicine and Biology, vol 333. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2468-1_11

Download citation

  • DOI: https://doi.org/10.1007/978-1-4899-2468-1_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-2470-4

  • Online ISBN: 978-1-4899-2468-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics