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The Gastrointestinal Tract

  • Franz Hartmann
  • Harro Jenss
Chapter
  • 113 Downloads

Abstract

With its mucosal surface thought to be 200 times the body surface area, the gastrointestinal tract is a major route of exposure to pathogenic organisms and environmental chemicals. Food- and water-borne chemicals enter the body via the gastrointestinal tract. Most agents are ingested; however, some inhaled substances are swallowed after being trapped in the mucus of the respiratory tract. Thus, apart from its classic role of nutrient absorption, the gastrointestinal tract must also protect the body from environmental assault (83, 89, 109, 137, 166).

Keywords

Bile Acid Intestinal Lumen Intestinal Flora Secretory Component Unstirred Layer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Aitio A, Marniemi J: Extrahepatic glucuronide conjugation. In: Extrahepatic Metabolism of Drugs and Other Foreign Compounds, p 365, Gram TE (ed.), MTP Press, Lancaster, 1980.Google Scholar
  2. 2.
    Albert A, Rees CW: Avidity of the tetracyclins for the cations of metals. Nature 177:433, 1956.PubMedCrossRefGoogle Scholar
  3. 3.
    Alberts B, Dennis B, Lewis J, et al: Molecular Biology of the Cell, Garland Publishing, New York, 1983.Google Scholar
  4. 4.
    Anderson KE, Schneider J, Pantuck EJ, et al: Acetaminophen metabolism in subjects fed charcoal-broiled beef. Clin Pharmacol Ther 34:369, 1983.PubMedCrossRefGoogle Scholar
  5. 5.
    Aries VC, Crowther JS, Drasar BS, et al: Bacteria and the etiology of cancer of the large bowel. Gut 10:334, 1969.PubMedCrossRefGoogle Scholar
  6. 6.
    Autrup H: Use of expiant cultures to study the metabolism of polycyclic aromatic hydrocarbons in the human gastrointestinal tract. In: Advances in Physiological Sciences, Vol 29, Gastrointestinal Defense Mechanisms, p 385, Mozik G, Hanninen O, Javor T (eds.), Pergamon Press, New York; Akademiai Kiado, Budapest, 1981.Google Scholar
  7. 7.
    Autrup H: Carcinogen metabolism in human tissues and cells. Drug Metab Rev 13:603, 1982.PubMedCrossRefGoogle Scholar
  8. 8.
    Banwell JG: Environmental contaminants and intestinal function. Environ Health Perspect 33:107, 1979.PubMedCrossRefGoogle Scholar
  9. 9.
    Barnik V, ReMine SG, Chiba M, et al: Isolation and characterization of colonic intraepithelial and lamina proprial lymphocytes. Gastroenterology 78:976, 1980.Google Scholar
  10. 10.
    Bienenstock J, Befus AD: Mucosal immunology. Immunology 41:249, 1980.PubMedGoogle Scholar
  11. 11.
    Bienenstock J, Befus AD: The gastrointestinal tract as an immune organ. In: Gastrointestinal Immunity for the Clinician, p 1, Sorter RG, Ku JB (eds.), Grune & Stratton, Orlando, 1985.Google Scholar
  12. 12.
    Bienenstock J, McDermott M, Belfus AD: A common mucosal immune system. In: Immunology of Breast Milk, p 91, Ogra PL, Dayton DH (eds.), Raven Press, New York, 1979.Google Scholar
  13. 13.
    Bienenstock P, McDermott M, Befus AD, et al: Mucosal immunology. Monogr Allergy 16:1, 1980.PubMedGoogle Scholar
  14. 14.
    Bloom BR: Natural killers to rescue immune surveillance? Nature 300:214, 1982.PubMedCrossRefGoogle Scholar
  15. 15.
    Bretscher MS: Membrane structure: Some general principles. Science 181:622, 1973.PubMedCrossRefGoogle Scholar
  16. 16.
    Byrne BM, Dankert J: Volatile fatty acids and aerobic flora in the gastrointestinal tract of mice under various conditions. Infect Immun 23:559, 1979.PubMedGoogle Scholar
  17. 17.
    Caldwell J: The metabolism of drugs by the gastrointestinal tract. In: Presystemic Drug Elimination, George CF, Shand DG, Renwick AG, et al. (eds.), Butterworths, London, 1982.Google Scholar
  18. 18.
    Chandra RK: Mucosal immune responses in malnutrition. Ann NY Acad Sci 409:345, 1983.PubMedCrossRefGoogle Scholar
  19. 19.
    Chandra RK: Nutritional modulation of intestinal mucosal immunity. Immunol Invest 18:119, 1989.PubMedCrossRefGoogle Scholar
  20. 20.
    Chhabra RS, Eastin WC Jr: Intestinal absorption and metabolism of xenobiotics in laboratory animals. In: Intestinal Toxicology, p 145, Schiller CM (ed.), Raven Press, New York, 1984.Google Scholar
  21. 21.
    Clifton G, Kaplowitz N: The glutathion S-transferase of the intestine in the rat. Cancer Res 37:788, 1977.PubMedGoogle Scholar
  22. 22.
    Colburn WA, Bekersky I, Min BH, et al: Contribution of gut contents, intestinal wall and liver to the first pass metabolism of clonazepam in the rat. Res Commun Chem Pathol Pharmacol 27:73, 1980.PubMedGoogle Scholar
  23. 23.
    Conolly ME, Davies DS, Dollery CT, et al: Metabolism of isoprenaline in dog and man. Br J Pharmacol 46:458, 1972.PubMedCrossRefGoogle Scholar
  24. 24.
    Creamer B: Biomembranes. In: Intestinal Absorption, Vol 4A, p 1, Smyth DH (ed.), Plenum Press, London, 1974.Google Scholar
  25. 25.
    Davies A: Investigation into the serological properties of dysentery stools. Lancet 2:1009, 1922.CrossRefGoogle Scholar
  26. 26.
    Dawson JR, Bridges JW: Guinea-pig intestinal sul-photransferases: An investigation using the cytosolic fraction. Biochem Pharmacol 30:2409, 1981.PubMedCrossRefGoogle Scholar
  27. 27.
    Dean JH, Cornacoff JB, Luster MI: Toxicity of the immune system: A review. In: Immunopharmacol-ogy Reviews, Vol 1, p 377, Hadden JW, Szentivanyi A (eds.), Plenum Press, New York, 1990.CrossRefGoogle Scholar
  28. 28.
    Deschner EE, De Cosse JJ, Sherlock P: Chemical and environmental agents in gastrointestinal carcinogenesis. Clin Gastroenterol 10:755, 1981.PubMedGoogle Scholar
  29. 29.
    Desnam ES, Levin RJ: An experimental method of identifying and quantifying the active transfer elec-trogenic component from the diffuse component during sugar absorption measured in vivo. J Physiol (Lond) 246:181, 1975.Google Scholar
  30. 30.
    Di Girolamo R, Liston J, Matches J: Ionic binding: The mechanism of viral uptake by shellfish mucus. Appl Environ Microbiol 33:19, 1977PubMedGoogle Scholar
  31. 31.
    Dobbins WO: Gut immunology and immunodeficiency. Curr Concepts Gastroenterol 1/2:6, 1983.Google Scholar
  32. 32.
    Doe WF: An overview of intestinal immunity and malabsorption. Am J Med 67:1077, 1979.PubMedCrossRefGoogle Scholar
  33. 33.
    Domellof L, Erikson S, Janunger DG: Carcinoma and possible precancerous changes of the gastric stump after Billroth II resection. Gastroenterology 73:462, 1977.PubMedGoogle Scholar
  34. 34.
    Donaldson RM: Role of indigenous enteric bacteria in intestinal function and disease. In: Handbook of Physiology, Sec. 9, p 301, Code CF (ed.), American Physiological Society, Washington, 1968.Google Scholar
  35. 35.
    Donaldson RM Jr, Toskes PP: The relation of enteric bacterial populations to gastrointestinal function and disease. In: Gastrointestinal Disease. Pathophysiology, Diagnosis, Management, 4th ed., p 107, WB Saunders, Philadelphia, 1989.Google Scholar
  36. 36.
    Donowitz M, Charney AN, Hefferman T: Effect of serotonin treatment on intestinal transport in the rabbit. Am J Physiol 232:85, 1977.Google Scholar
  37. 37.
    Dossetar J: Drug interaction with oral contraceptives. Br Med J 4:467, 1975.CrossRefGoogle Scholar
  38. 38.
    Drasar BS, Hill MJ: Human Intestinal Flora, Academic Press, New York, 1974.Google Scholar
  39. 39.
    Drasar BS, Shiner M, McLeod GM: Studies on the intestinal flora. I. The bacterial flora of the gastrointestinal tract in healthy and achlorhydric persons. Gastroenterology 56:71, 1969.PubMedGoogle Scholar
  40. 40.
    Drasar BS, Hill MJ, Williams RED: The significance of the gut flora in safety testing of food additives. In: Metabolic Aspects of Food Safety, p 245, Roe FJC (ed.), Blackwell Scientific Publications, London, 1970.Google Scholar
  41. 41.
    Eade MN: Gut circulation and absorption, a review, part I. NZ Med J 84:10, 1976.Google Scholar
  42. 42.
    Ernst PB, Scicchitano R, Underdown BJ, et al: Oral immunization and tolerance. In: Immunology of the Gastrointestinal Tract and Liver, Heyworth MF, Jones AL (eds.), p 125, Raven Press, New York, 1988.Google Scholar
  43. 43.
    Farthing MJG, Vinson GP, Edwards CR, et al: Testosterone metabolism by the rat gastrointestinal tract, in vitro and in vivo. Gut 23:226, 1982.PubMedCrossRefGoogle Scholar
  44. 44.
    Fischer LJ, Millburn P: Stilbesterol transport and glu-curonide formation in everted sacs of rat intestine. J Pharmacol Exp Ther 175:267, 1970.PubMedGoogle Scholar
  45. 45.
    Florey H: Mucins and the protection of the body. Proc R Soc Lond [Biol] 143:147, 1955.CrossRefGoogle Scholar
  46. 46.
    Forstner G, Wesley A, Forstner J: Clinical aspects of gastrointestinal mucus. In: Mucus in Health and Disease II, p 189, Chantier EN, Elder JB, Elstein M (eds.), Plenum Press, New York, 1982.Google Scholar
  47. 47.
    Gallin JI, Fauci AS (eds.): Advances in Host Defense Mechanisms, Mucosal Immunity, Raven Press, New York, 1985.Google Scholar
  48. 48.
    George CF: Drug metabolism by the gastrointestinal mucosa. Clin Pharmacokinet 6:259, 1981.PubMedCrossRefGoogle Scholar
  49. 49.
    Gibaldi M, Perrier D: Route of administration and drug disposition. Drug Metab Rev 3:185, 1974.PubMedCrossRefGoogle Scholar
  50. 50.
    Gibson GG, Hubbard R, Parke DV (eds.): Immuno-toxicology, Academic Press, New York, 1983.Google Scholar
  51. 51.
    Gilette R, David DC, Sesame HA: Cytochrome P-450 and its role in drug metabolism. Ann Rev Pharmacol 12:57, 1972.CrossRefGoogle Scholar
  52. 52.
    Goldin BR, Gorbach SL: The relationship between diet and rat fecal bacterial enzymes implicated in colon cancer. J Natl Cancer Inst 57:371, 1976.PubMedGoogle Scholar
  53. 53.
    Goldin BR, Gorbach SL: Effect of lactobacillus acidophilus dietary supplements on 1,2-dimethylhy-drazine dihydrochloride induced intestinal cancer in rats. J Natl Cancer Inst 64:263, 1980.PubMedGoogle Scholar
  54. 54.
    Goldin BR, Swenson L, Dwyer J, et al: Effect of diet and lactobacillus supplements on human fecal bacterial enzymes. J Natl Cancer Inst 64:225, 1980.Google Scholar
  55. 55.
    Gray JDA, Shiner M: Influence of gastric pH on gastric and jejunal flora. Gut 8:574, 1967.PubMedCrossRefGoogle Scholar
  56. 56.
    Green ML, Saunders DR: Metabolism of tetrahydrocannabinol by the small intestine. Gastroenterology 66:365, 1974.Google Scholar
  57. 57.
    Guy-Grand D, Griscelli C, Vassali P: Peyer’s patches, gut IgA plasma cells and thymic function: Study in nude mice bearing thymic grafts. J Immunol 115:361, 1975.PubMedGoogle Scholar
  58. 58.
    Guzelian PS: Chlordecone poisoning: A case study in approaches for detoxification of humans exposed to environmental chemicals. Drug Metab Rev 13:663, 1982.PubMedCrossRefGoogle Scholar
  59. 59.
    Hanson LA, Ahlstedt S, Andersson B, et al: Mucosal immunity. Ann NY Acad Sci 409:1, 1983.PubMedCrossRefGoogle Scholar
  60. 60.
    Hartiala KJW: Metabolism of hormones, drugs and other substances by the gut. Physiol Rev 53:496, 1973.PubMedGoogle Scholar
  61. 61.
    Hartmann F, Bisell DM: Metabolism of heme and bilirubin in rat and human small intestinal mucosa. J Clin Invest 70:23, 1982.PubMedCrossRefGoogle Scholar
  62. 62.
    Hartmann F, Gruenke LD, Craig JC, et al: Chlor-promazine metabolism in extracts of liver and small intestine from guinea pig and from man. Drug Met Dispos 11:244, 1983.Google Scholar
  63. 63.
    Hayton WL: Rate-limiting barriers to intestinal drug absorption: A review. J Pharmacokin Biopharm 8: 321, 1980.CrossRefGoogle Scholar
  64. 64.
    Hazlewood CF: Bound water in biology. Acta Bio-chim Biophys 12:263, 1977.Google Scholar
  65. 65.
    Hechter O: Intracellular water structure and mechanisms of cellular transport. Ann NY Acad Sci 195: 625, 1972.CrossRefGoogle Scholar
  66. 66.
    Hietanen E: Oxidation and subsequent glucuronida-tion of 3,4-benzopyrene in everted intestinal sacs in control and 3-methyl-cholanthrene-pretreated rats. Pharmacol 21:233, 1980.CrossRefGoogle Scholar
  67. 67.
    Hietanen E, Linnainmaa K, Vainio H: Effects of phenoxyherbicides and glyphosphate on the hepatic and intestinal biotransformation activities in the rat. Acta Pharmacol et Toxicol 53:103, 1983.CrossRefGoogle Scholar
  68. 68.
    Hill MJ: Bacteria and etiology of colonic cancer. Cancer 34:815, 1974.PubMedCrossRefGoogle Scholar
  69. 69.
    Hill MJ: The role of colon anaerobes in the metabolism of bile acids and steroids and its relation to color cancer. Cancer 36:2387, 1975.PubMedCrossRefGoogle Scholar
  70. 70.
    Hill MJ: Diet and the human intestinal flora. Cancer Res 41:3778, 1981.PubMedGoogle Scholar
  71. 71.
    Hill MF, Drasar BS, Aries V, et al: Bacteria and aetiology of cancer of large bowel. Lancet 1:95, 1971.PubMedCrossRefGoogle Scholar
  72. 72.
    Hinderung PH, Garrett ER, Webster RC: Pharmacokinetics of b-methyldigoxin in healthy humans. II. Oral studies and bioavailability. J Pharm Sci 66:314, 1977.CrossRefGoogle Scholar
  73. 73.
    Hoensch H, Hartmann F: The intestinal enzymatic biotransformation system: Potential role in protection from colon cancer. Hepato-gastroenterol 28:221, 1981.Google Scholar
  74. 74.
    Hoensch H, Hurt R, Hartmann F: Biotransformation of xenobiotics in human intestinal mucosa. Env Health Perspect 33:71, 1979.CrossRefGoogle Scholar
  75. 75.
    Hoensch HP, Schwenk M: Intestinal absorption and metabolism of xenobiotics in humans. In: Intestinal Toxicology, p 169, Schiller CM (ed.), Raven Press, New York, 1984.Google Scholar
  76. 76.
    Hoensch HP, Steinhardt JH, Weiss G, et al: Effects of semisynthetic diets on xenobiotic metabolizing enzyme activity and morphology of small intestinal mucosal in humans. Gastroenterology 86:1519, 1984.PubMedGoogle Scholar
  77. 77.
    Hoensch H, Woo CH, Raffin SB, et al: Oxidative metabolism of foreign compounds in rat small intestine. Cellular localization and dependence on dietary iron. Gastroenterology 70:1063, 1976.PubMedGoogle Scholar
  78. 78.
    Hollander F: The two-component mucus barrier. Arch Int Med 93:107, 1954.CrossRefGoogle Scholar
  79. 79.
    Hopf U, Brandtzaeg P, Hutteroth TH, et al: In vivo and in vitro binding of IgA to the plasma membrane of hepatocytes. Scand J Immunol 8:543, 1978.PubMedCrossRefGoogle Scholar
  80. 80.
    Horowitz MI: Gastrointestinal glycoproteins. In: The Glycoconjugates, Vol I, p 189, Horowitz MI, Pigman W (eds.), Academic Press, New York, 1977.Google Scholar
  81. 81.
    Iglewski WJ, Gerhardt NB: Identification of an antibiotic producing bacterium from the human intestinal tract and characterization of its antimicrobial product. Antimicrob Agents Chemother 13:81, 1978.PubMedCrossRefGoogle Scholar
  82. 82.
    Ito S: The enteric surface coast on cat intestinal microvilli. J Cell Biol 27:475, 1965.PubMedCrossRefGoogle Scholar
  83. 83.
    Heyworth MF, Jones AL (eds.): Immunology of the Gastrointestinal Tract and Liver, Raven Press, New York, 1988.Google Scholar
  84. 84.
    Iturri SJ, Wolff D: Inhibition of the active transport of r>glucose and L-tyrosine by DDT and DDE in the rat small intestine. Comp Biochem Physiol 71:131, 1982.CrossRefGoogle Scholar
  85. 85.
    Iwamoto K, Klassen CD: First pass effect of morphine in rats. J Pharmacol Exp Ther 200:236, 1977.PubMedGoogle Scholar
  86. 86.
    Jarvenpaa P, Kosunen T, Fotsis T, et al: In vitro metabolism of estrogens by isolated intestinal microorganisms and by human foecal microflora. J Steroid Biochem 13:345, 1980.PubMedCrossRefGoogle Scholar
  87. 87.
    Joel DD, Sordat B, Hess MW, et al: Uptake and retention of particles from the intestine by Peyer’s patches in mice. Experientia 26:694A, 1970.Google Scholar
  88. 88.
    Kagnoff MF: Effects of antigen-feeding on intestinal and systemic immune responses. I. Priming of precursor cytotoxic T cells by antigen feeding. J Immunol 120:395, 1978.PubMedGoogle Scholar
  89. 89.
    Kagnoff MF: Immunology of the digestive system. In: Physiology of the Gastrointestinal Tract, 2nd ed., p 1699, Johnson LR (ed.), Raven Press, New York, 1987.Google Scholar
  90. 90.
    Kagnoff MF, Donaldson RM Jr, Trier JS: Organ culture of rabbit small intestine: Prolonged in vitro steady-state protein synthesis and secretion and secretory IgA secretion. Gastroenterology 63:541, 1972.PubMedGoogle Scholar
  91. 91.
    Kinlen LJ: Meat and fat consumption and cancer mortality: A study of strict religious orders in Britain. Lancet 1:946, 1982.PubMedCrossRefGoogle Scholar
  92. 92.
    Klippert P, Borm P, Noordhoek J: Prediction of intestinal first-pass effect of phenacetin in the rat from enzyme kinetic data correlation with in vivo data using mucosal blood flow. Biochem Pharmacol 31: 2545, 1982.PubMedCrossRefGoogle Scholar
  93. 93.
    Knodell RG, Spector MH, Brooks DA, et al: Alterations in pentobarbital pharmacokinetics in response to parenteral and enteral alimentation in the rat. Gastroenterology 79:1211, 1980.PubMedGoogle Scholar
  94. 94.
    Koster AS, Noordhoek J: Similarity of rat intestinal and hepatic microsomal 7-HO-coumarin-UPP-glucu-ronyltransferase. Biochem Pharmacol 31:2701, 1982.PubMedCrossRefGoogle Scholar
  95. 95.
    Koster AS, Noordhoek J: Glucuronidation in the rat intestinal wall. Biochem Pharmacol 32:895, 1983.PubMedCrossRefGoogle Scholar
  96. 96.
    Laquerur GL, Spatz M: Toxicology of cycasin. Cancer Res 28:2262, 1968.Google Scholar
  97. 97.
    Lauterbach F: Intestinal secretion of organic ions and drugs. In: Intestinal Permeation, p 173, Kramer M, Lauterbach F (eds.), Excerpta Medica, Amsterdam, 1974.Google Scholar
  98. 98.
    Le Fevre ME, Joel DD: Minireview: Intestinal absorption of particulate matter. Life Sci 21:1403, 1977.CrossRefGoogle Scholar
  99. 99.
    Levin RJ: Assessing small intestinal function in health and disease in vivo and in vitro. Scand J Gastroenterol 17 (Suppl 74):31, 1982.Google Scholar
  100. 100.
    Levin W, Jagi H, Conney A, et al: Oxidative metabolism of polycyclic aromatic hydrocarbons to ultimate carcinogens. Drug Metab Rev 13:555, 1982.PubMedCrossRefGoogle Scholar
  101. 101.
    Lindenbaum J, Rund DG, Butho VP, et al: Inactivation of digoxin by the gut flora: Reversal by antibiotic therapy. N Engl J Med 305:789, 1981.PubMedCrossRefGoogle Scholar
  102. 102.
    Lipkin M: Proliferation and differentiation of gastrointestinal cells. Physiol Rev 53:891, 1973.PubMedGoogle Scholar
  103. 103.
    Lipkin M: Proliferation and differentiation of normal and diseased gastrointestinal cells. In: Physiology of the Gastrointestinal tract, 2nd ed., p 255, Johnson LR (ed.), Raven Press, New York, 1987.Google Scholar
  104. 104.
    Lucas ML: The association between acidification and electronic events in the rat proximal jejunum. J Physiol (Lond) 257:645, 1976.Google Scholar
  105. 105.
    Lucas ML, Schneider W, Haberich FJ, et al: Direct measurement by pH microelectrode of the pH microclimate in rat proximal jejunum. Proc R Soc Lond [Biol] 192:39, 1975.CrossRefGoogle Scholar
  106. 106.
    Mahon WA, Inoba T, Stone RM: Metabolism of flur-azepam by the small intestine. Clin Pharmacol Ther 22:228, 1977.PubMedGoogle Scholar
  107. 107.
    Marshall T, Allen A: The isolation and characterization of the high-molecular-weight glycoprotein from pig colonic mucus. Biochem J 173:569, 1978.PubMedGoogle Scholar
  108. 108.
    McElhaney RN: Membrane lipid, not polarized water, is responsible for the semipermeable properties of living cells. Biophys J 15:777, 1975.PubMedCrossRefGoogle Scholar
  109. 109.
    McNabb PC, Tomasi TB: Host defense mechanisms at mucosal surfaces. Annu Rev Microbiol 35:477, 1981.PubMedCrossRefGoogle Scholar
  110. 110.
    Metchnikoff E: The prolongation of life, GP Putnam, New York, 1908.Google Scholar
  111. 111.
    Miller HRP, Nawa J: Nippostrongylus brasiliensis: Intestinal goblet cell response in adoptively immunized rats. Exp Parasitai 47:81, 1979.CrossRefGoogle Scholar
  112. 112.
    Moore WEC, Holdeman CV: Discussion of current bacteriologic investigations of the relationships between intestinal flora, diet and colon cancer. Cancer Res 35:3418, 1975.Google Scholar
  113. 113.
    Mortillardo NA, Granger DN, Kuietys PR, et al: Effects of histamine and histamine antogonists on intestinal capillary permeability. Am J Physiol 240: G381, 1981.Google Scholar
  114. 114.
    Mower HF, Ray RM, Shoff R: Fecal bile acids in two Japanese populations with different colon cancer risks. Cancer Res 39:328, 1979.PubMedGoogle Scholar
  115. 115.
    Nagura H, Smith PD, Nakane PK, et al: IgA in human bile and liver. J Immunol 126:587, 1981.PubMedGoogle Scholar
  116. 116.
    Nelson E: Physicochemical factors influencing the absorption of erythromycin and its esters. Chem Pharm Bull 10:1099, 1962.CrossRefGoogle Scholar
  117. 117.
    Neutra MR, Forstner JF: Gastrointestinal mucus: Synthesis, secretion, and function. In: Physiology of the Gastrointestinal Tract, 2nd ed., p 975, Johnson LR (ed.), Raven Press, New York, 1987.Google Scholar
  118. 118.
    Nigro ND: Animal studies implicating fat and fecal steroids in intestinal cancer. Cancer Res 41:3769, 1981.PubMedGoogle Scholar
  119. 119.
    Ochsenfahrt H, Winne D: The contribution of solvent drag to the intestinal absorption of the basic drugs amidopyrine and antipyrine from the jejunum of the rat. Arch Pharmacol 281:175, 1974.CrossRefGoogle Scholar
  120. 120.
    Ochsenfahrt H, Winne D: The contribution of solvent drag to the intestinal absorption of the acidic drugs benzoic acid and salicylic acid from the jejunum of the rat. Arch Pharmacol 281:197, 1974.CrossRefGoogle Scholar
  121. 121.
    Ogra PL, Karzon DT, Righthand F, et al: Immunoglobulin response in serum and secretions after immunization with live and inactivated poliovaccine and natural infection. N Engl J Med 279:893, 1968.PubMedCrossRefGoogle Scholar
  122. 122.
    Owen RL: Sequential uptake of horseradish peroxidase by lymphoid follicle epithelium of Peyer’s patches in the normal unobstructed mouse intestine: An ultrastructural study. Gastroenterology 72:440, 1977.PubMedGoogle Scholar
  123. 123.
    Pantuck EJ, Hsiao KC, Kaplan SA: Effects of enzyme induction on intestinal phenacetin metabolism in the rat. J Pharmacol Exp Ther 191:45, 1974.PubMedGoogle Scholar
  124. 124.
    Pantuck EJ, Hsiao KC, Kuntzmann R: Intestinal metabolism of phenacetin in the rat: Effect of charcoal-broiled beef and rat chow. Science 187:744, 1975.PubMedCrossRefGoogle Scholar
  125. 125.
    Pascoe GA, Wong IS, Soliven E, et al: Regulation of intestinal cytochrome P-450 and heme by dietary nutrients. Biochem Pharmacol 32:3027, 1983.PubMedCrossRefGoogle Scholar
  126. 126.
    Pfeiffer CA: Gastroenterologie response to environmental agents—absorption and interactions. In: Handbook of Physiology, Sec 9, p 349, Lee DHK (ed.), American Physiological Society, Bethesda, 1977.Google Scholar
  127. 127.
    Pinkus LM, Kutly JN, Jakoby WB: The glutathione S-transferase as a possible detoxification system of rat intestinal epithelium. Biochem Pharmacol 26: 2359, 1977.PubMedCrossRefGoogle Scholar
  128. 128.
    Read NW, Barber DC, Levin RJ, et al: Unstirred layer and kinetics of electronic glucose absorption in the human jejunum in situ. Gut 18:865, 1977.PubMedCrossRefGoogle Scholar
  129. 129.
    Reddy BS, Wynder EL: Large-bowel carcinogenesis: Fecal constituents of populations with diverse incidence rates of colon cancer. J Natl Cancer Inst 50:1437, 1973.PubMedGoogle Scholar
  130. 130.
    Reddy WS, Weisburger JH, Wynder EL: Fecal bacterial glucuronidase: Control by diet. Science 183:416, 1974.PubMedCrossRefGoogle Scholar
  131. 131.
    Report from the International Agency for Research on Cancer, Intestinal Microecology Group: Dietary fibre transit-time, fecal bacteria, steroids and colon cancer in two Scandinavian populations. Lancet 2: 207, 1977.Google Scholar
  132. 132.
    Richter E, Fichtl B, Schafer SG: Effects of dietary paraffin, squalene and sucrose polyester on residue disposition and elimination of hexachlorobenzene in rats. Chem Biol Interact 40:335, 1982.PubMedCrossRefGoogle Scholar
  133. 133.
    Rontledge PA, Shand DG: Presystemic drug elimination. Annu Rev Pharmacol Toxicol 19:447, 1979.CrossRefGoogle Scholar
  134. 134.
    Salviolo G, Salata R, Bondi M, et al: Bile acid transformation by the intestinal flora and cholesterol saturation in bile. Digestion 23:80, 1981.CrossRefGoogle Scholar
  135. 135.
    Savage DC: Microbial ecology of the gastrointestinal tract. Annu Rev Microbiol 31:107, 1977.PubMedCrossRefGoogle Scholar
  136. 136.
    Schedl HP: Water and electrolyte transport: Clinical aspects. Med Clin North Am 58:1429, 1974.PubMedGoogle Scholar
  137. 137.
    Schedl HP: Environmental factors and the development of disease and injury in the alimentary tract. Environ Health Perspect 20:39, 1977.PubMedCrossRefGoogle Scholar
  138. 138.
    Schedl HP: Intestinal disease and the urban environment. Environ Health Perspect 33:115, 1979.PubMedCrossRefGoogle Scholar
  139. 139.
    Scheline RR: Metabolism of foreign compounds by gastrointestinal microorganisms. Pharmacol Rev 25: 451, 1973.PubMedGoogle Scholar
  140. 140.
    Scheline RR: Drug metabolism by the gastrointestinal microflora. In: Extrahepatic Metabolism of Drugs and Other Foreign Compounds, p 551, Gram TE (ed.), MTP Press, Lancaster, 1980.Google Scholar
  141. 141.
    Seitz HK, Korsten MA, Lieber CS: Ethanol oxidation by intestinal microsomes: Increased activity after chronic ethanol administration. Life Sci 25:1443, 1979.PubMedCrossRefGoogle Scholar
  142. 142.
    Shand DG, Rangno RE: The disposition of propranolol. I. Elimination during oral absorption in man. Pharmacology 7:159, 1972.PubMedCrossRefGoogle Scholar
  143. 143.
    Sharma RP (ed.): Immunologic Considerations in Toxicology, Vol I, CRC Press, Boca Raton, 1981.Google Scholar
  144. 144.
    Sharma RP (ed.): Immunologic Considerations in Toxicology, Vol 2, CRC Press, Boca Raton, 1981.Google Scholar
  145. 145.
    Shorter RG, Tomasi TB: Gut immune mechanisms. Ann Intern Med 27:247, 1982.Google Scholar
  146. 146.
    Simon GL, Gorbach SL: Intestinal flora in health and disease. Gastroenterology 86:174, 1984.PubMedGoogle Scholar
  147. 147.
    Simon GL, Gorbach SL: Intestinal flora in health and disease. In: Johnson LR (ed.), Physiology of the Gastrointestinal Tract, 2nd ed., p 1729, Raven Press, New York, 1987.Google Scholar
  148. 148.
    Sinrala M, Lehtola J, Ihamaki T: Atropic gastritis and its sequelae. Results of 19–23 years follow-up examinations. Scand J Gastroenterol 9:441, 1974.Google Scholar
  149. 149.
    Smith RL: The role of the gut flora in the conversion of inactive compounds to active metabolites. In: Symposium on Mechanisms of Toxicity, p 229, Aldridge WN (ed.), Macmillan, New York, 1971.Google Scholar
  150. 150.
    Smithson KW, Millar DB, Jacobs LR, et al: Intestinal diffusion barrier: Unstirred water layer or membrane surface mucous coat. Science 214:1241, 1981.PubMedCrossRefGoogle Scholar
  151. 151.
    Sparnins VL, Venegas PL, Wattenberg LW: Glutathione S-transferase activity: Enhancement by compounds inhibiting chemical carcinogenesis and by dietary constituents. J Natl Cancer Inst 68:493, 1982.PubMedGoogle Scholar
  152. 152.
    Stockbrugger RW, Cotton PB, Eugenides N, et al: Intragastric nitrites, nitrosamines and bacterial overgrowth during Cimetidine treatment. Gut 23:1048, 1982.PubMedCrossRefGoogle Scholar
  153. 153.
    Stohs SJ, Grafstrom RC, Burke MD, et al: The isolation of rat intestinal microsomes with stable cytochrome P-450 and their metabolism of benzo(a)py-rene. Arch Biochem Biophys 177:105, 1976.PubMedCrossRefGoogle Scholar
  154. 154.
    Tagliabue A, Befus AD, Clark DA, et al: Characteristics of natural killer cells in the murine intestinal epithelium and lamina propria. J Exp Med 155:1785, 1982.PubMedCrossRefGoogle Scholar
  155. 155.
    Thomas ABR: Unstirred water layers: A basic mechanism of gastrointestinal mucosal cell cytoprotection. In: Basic Mechanisms of Gastrointestinal Mucosal Cell Injury and Protection, p 327, Harmon JW (ed.), Williams & Wilkins, Baltimore, 1981.Google Scholar
  156. 156.
    Tomasi TB, Bienenstock J: Secretory immunoglobulins. Adv Immunol 9:1, 1968.PubMedCrossRefGoogle Scholar
  157. 157.
    Tomasi TB, Grey HM: Structure and function of immunoglobulin A. Prog Allergy 16:81, 1972.PubMedGoogle Scholar
  158. 158.
    Tomasi TB, Tan EM, Solomon A, et al: Characteristics of an immune system common to certain external secretions. J Exp Med 121:101, 1965.PubMedCrossRefGoogle Scholar
  159. 159.
    Tredger JM, Chhabra RS: Factors affecting the properties of mixed-function oxidases in the liver and small intestine of neonatal rabbits. Drug Metab Dispos 8:16, 1980.PubMedGoogle Scholar
  160. 160.
    Tsuj A, Miyamoto E, Kagami I, et al: Q absorption of β-lactam antibiotics I: Kinetic assessment of competing absorption and degradation in GI tract. J Pharm Sci 67:1701, 1978.CrossRefGoogle Scholar
  161. 161.
    Underdown BJ, Schiff JM: Immunoglobin A: Strategic defense initiative at the mucosal surface. Annu Rev Immunol 4:389, 1986.PubMedCrossRefGoogle Scholar
  162. 162.
    Underdown BJ, Roberts-Thomson IC, Anders RF, et al: Giardiasis in mice: Studies on the characteristics of chronic infection in C3H/He mice. J Immunol 126: 669, 1981.PubMedGoogle Scholar
  163. 163.
    Vango D, Moskowitz M, Floch MH: Faecal bacterial flora in cancer of the colon. Gut 21:701, 1980.CrossRefGoogle Scholar
  164. 164.
    Vimmo WS: Drugs, diseases and altered gastric emptying. Clin Pharmacokinet 1:189, 1976.CrossRefGoogle Scholar
  165. 165.
    Waksman BH: The homing pattern of thymus-de-rived lymphocytes in calf and neonatal mouse Peyer’s patches. J Immunol 111:878, 1973.PubMedGoogle Scholar
  166. 166.
    Walker WA: Host defense mechanisms in the gastrointestinal tract. Pediatrics 57:901, 1976.PubMedGoogle Scholar
  167. 167.
    Walker WA, Isselbacher KJ: Intestinal antibodies. N Engl J Med 297:767, 1977.PubMedCrossRefGoogle Scholar
  168. 168.
    Walker WA, Isselbacher KJ, Block KJ: Intestinal uptake of macromolecules: Effect of oral immunization. Science 177:608, 1972.PubMedCrossRefGoogle Scholar
  169. 169.
    Wattenberg LW: Inhibition of neoplasia by minor dietary constituents. Cancer Res 43 (Suppl):2448s, 1983.Google Scholar
  170. 170.
    Wattenberg LW, Leong JC, Strand PJ: Benzo(a)pyrene hydroxylase activity in the gastrointestinal tract. Cancer Res 22:1120, 1962.PubMedGoogle Scholar
  171. 171.
    Wattenberg LW, Coccia JB, Cam LKT: Inhibitory effects of phenolic compounds of benzo(a)pyrene-induced neoplasia. Cancer Res 40:2820, 1980.PubMedGoogle Scholar
  172. 172.
    Wattenberg LW, Borchert P, Destafney CM, et al: Effects of p-methoxyphenol and diet on carcinogen-induced neoplasia of the mouse forestomach. Cancer Res 43:4747, 1983.PubMedGoogle Scholar
  173. 173.
    Weisburger JH, Marwuardt H, Hirota N, et al: Induction of cancer in the glandular stomach in rats by an extract of nitrite-treated fish. J Natl Cancer Inst 64: 163, 1980.PubMedGoogle Scholar
  174. 174.
    Westergaard H, Dietschy JM: Delineation of the dimensions and permeability characteristics of the two major diffusion barriers to passive mucosal uptake in the rabbit intestine. J Clin Invest 54:718, 1974.PubMedCrossRefGoogle Scholar
  175. 175.
    Williams RC, Gibbons RJ: Inhibition of bacterial adherence by secretory immunoglobin A: A mechanism of antigen disposal. Science 177:697, 1972.PubMedCrossRefGoogle Scholar
  176. 176.
    Williams RT: Toxicological implications of biotransformation by intestinal microflora. Toxicol Appl Pharmacol 23:769, 1972.PubMedCrossRefGoogle Scholar
  177. 177.
    Williams SE, Turnberg LA: Retardation of acid diffusion by pig gastric mucus: A potential role in mucosal protection. Gastroenterology 79:299, 1980.PubMedGoogle Scholar
  178. 178.
    Wilson FA, Dietschy JM: The intestinal unstirred layer: Its surface area and effect on active transport kinetics. Biochim Biophys Acta 363:112, 1974.PubMedCrossRefGoogle Scholar
  179. 179.
    Winne D: Rat jejunum perfused in situ: Effect of perfusion rate and intraluminal radius on absorption rate and effective unstirred layer thickness. Naunyn-Schmiedebergs Arch Pharmacol Exp Pathol 307:265, 1979.CrossRefGoogle Scholar
  180. 180.
    Winne D: Influence of blood flow on intestinal absorption of xenobiotics. Pharmacology 21:1, 1980.PubMedCrossRefGoogle Scholar
  181. 181.
    Wollenberg P, Ullrich V: The drug monooxygenase system in the small intestine. In: Extrahepatic Metabolism of Drugs and Other Foreign Compounds, p 267, 1980, Gram TE (ed.), SP Medical & Scientific Books, London, 1980.Google Scholar
  182. 182.
    Wollenberg P, Ullrich V, Rummel W: Conjugation of 1-naphthol and transport of 1-naphthol-conjugates in the vascularly perfused small intestine of the mouse. Biochem Pharmacol 32:2103, 1983.PubMedCrossRefGoogle Scholar
  183. 183.
    Wynder EL: The epidemiology of large bowel cancer. Cancer Res 35:3388, 1975.PubMedGoogle Scholar
  184. 184.
    Yamana T, Tsuji A: Comparative stability of cephalosporins in aqueous solution: Kinetics and mechanisms of degradation. J Pharm Sci 65:1563, 1976.PubMedCrossRefGoogle Scholar
  185. 185.
    Zamcheck N, Grable E, Ley A, et al: Occurrence of gastric cancer among patients with pernicious anemia at the Boston City Hospital. N Engl J Med 252: 1103, 1955.PubMedCrossRefGoogle Scholar
  186. 186.
    Zeigler EE, Edwards BB, Jensen RL, et al: Absorption and retention of lead by infants. Pediatr Res 12:29, 1978.CrossRefGoogle Scholar

Recommended Readings

  1. Brostoff J, Challacombe SJ (eds.): Food Allergy and Intolerance: Part I.Basic Mechanisms, Bailliere Tindall, London, 1987.Google Scholar
  2. Koster AS, Richter E, Hartmann V, et al: Intestinal Metabolism of Xenobiotics, Gustav Fisher Verlag, Stuttgart, 1989.Google Scholar

Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Franz Hartmann
  • Harro Jenss

There are no affiliations available

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