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The Skin

  • David R. Bickers
Chapter
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Abstract

The skin is a marvelous organ that functions as one of the body’s major interfaces with the environment and, in that anatomic position, has at least two major functional requirements. First, it must provide a protective barrier that severely limits the ability of potentially toxic agents in the environment to penetrate into the body where injurious effects can occur. Conversely, the skin must also limit the egress of essential body constituents into the environment. The second major functional requirement for this organ is sufficient flexibility and elasticity to permit maximum freedom of movement while simultaneously possessing enough tensile strength to resist tearing by physical forces in the environment.

Keywords

Stratum Corneum Hair Follicle Sweat Gland Percutaneous Absorption Eccrine Sweat Gland 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Akin FJ, Norred WP: Factors affecting measurement of aryl hydrocarbon hydroxylase activity in mouse skin. J Invest Dermatol 67:709, 1976.PubMedCrossRefGoogle Scholar
  2. 2.
    Bickers DR, Kappas A: The skin as a site of chemical metabolism. In: Extrahepatic Metabolism of Drugs and Other Foreign Compounds, p 295, Gram TE (ed.), SP Medical & Scientific Books, New York, 1980.Google Scholar
  3. 3.
    Bickers DR, Kappas A, Alvares AP: Differences in inducibility of hepatic and cutaneous drug metabolizing enzymes and cytochrome P450 by polychlori-nated biphenyls and 1, 1, 1-trichloro-2,2-bis(p-chloro-phenyl)ethane (DDT). J Pharmacol Exp Ther 188:300, 1974.PubMedGoogle Scholar
  4. 4.
    Blalock JE: The immune system as a sensory organ. J Immunol 132:1067, 1984.PubMedGoogle Scholar
  5. 5.
    Blank IH: Factors which influence the water content of the stratum corneum. J Invest Dermatol 18:433, 1952.PubMedGoogle Scholar
  6. 6.
    Charnetski WA, Stevens WE: Organochlorine insecticide residues in preen glands of ducks: Possibility of residue excretion. Bull Environ Contam Toxicol 12:672, 1974.PubMedCrossRefGoogle Scholar
  7. 7.
    Cline PR, Rice RH: Modulation of involucrin and envelope competence in human keratinocytes by hydrocortisone, retinyl acetate and growth onset. Cancer Res 43:3203, 1983.PubMedGoogle Scholar
  8. 8.
    Downing DT, Stewart ME, Wertz PW, et al: Skin lipids. Comp Biochem Physiol 4:673, 1983.Google Scholar
  9. 9.
    Epstein EH Jr, Munderloh N: Human skin collagen. Presence of type I and type III at all levels of the dermis. J Biol Chem 253:1336, 1978.PubMedGoogle Scholar
  10. 10.
    Epstein EH Jr, Williams ML, Elias PM: Steroid sulfatase, X-linked icthyosis, and stratum corneum cell cohesion. Arch Dermatol 117:761, 1981.PubMedCrossRefGoogle Scholar
  11. 11.
    Franz RT: On the relevance of in vitro data. J Invest Dermatol 64:190, 1975.PubMedCrossRefGoogle Scholar
  12. 12.
    Granstein RD, Lowy A, Greene MI: Epidermal antigen-presenting cells in activation of suppression: Identification of a new functional type of ultraviolet radiation-resistant epidermal cell. J Immunol 132:563, 1984.PubMedGoogle Scholar
  13. 13.
    Hammel HT: Regulation of internal body temperature. Annu Rev Physiol 30:641, 1968.PubMedCrossRefGoogle Scholar
  14. 14.
    Hersey P, Haran G, Hasic E, et al: Alteration of T cell subsets and induction of suppressor T cell activity in normal subjects after exposure to sunlight. J Immunol 131:171, 1983.PubMedGoogle Scholar
  15. 15.
    Kligman AM: A biological brief on percutaneous absorption. Drug Dev Ind Pharm 9:521, 1983.CrossRefGoogle Scholar
  16. 16.
    Luger TA, Stadler BM, Katz SI, et al: Epidermal cell (keratinocyte)-derived thymocyte activating factor (ETAF). J Immunol 127:1493, 1981.PubMedGoogle Scholar
  17. 17.
    Marzulli FN, Maibach HI: The hexachlorophene story. In: Animal Models in Dermatology, p 156, Maibach HI (ed.), Edinburgh, Churchill-Livingstone, 1975.Google Scholar
  18. 18.
    Meek RL, Lonsdale-Eccles JD, Dale BA: Epidermal filaggrin is synthesized on a large messenger ribonucleic acid as a high-molecular-weight precursor. Biochemistry 22:4867, 1983.PubMedCrossRefGoogle Scholar
  19. 19.
    Nemanick MK, Whitney J, Arnaud S, et al: Vitamin D3 production by cultured human keratinocytes and fibroblasts. Biochem Biophys Res Commun 115:444, 1983.CrossRefGoogle Scholar
  20. 20.
    Pathak MA, Kowichi J, Szabo G, et al: Sunlight and melanin pigmentation. In: Photochemical and Photo-biological Reviews, Vol 1, p 211, Smith KC (ed.), Plenum Press, New York, 1976.Google Scholar
  21. 21.
    Pohl RJ, Philpot RN, Fouts JR: Cytochrome P-450 content and mixed function oxidase activity in microsomes isolated from mouse skin. Drug Metab Dispos 4:442, 1976.PubMedGoogle Scholar
  22. 22.
    Pramanik AK, Hansen RC: Transcutaneous gamma benzene hexachloride absorption and toxicity in infants and children. Arch Dermatol 115:1224, 1979.PubMedCrossRefGoogle Scholar
  23. 23.
    Rucker RB, Murray J: Cross-linking amino acids in collagen and elastin. Am J Clin Nutr 31:1221, 1978.PubMedGoogle Scholar
  24. 24.
    Sato K: The physiology and pharmacology of the eccrine sweat gland. In: Biochemistry and Physiology of the Skin, Vol 1, p 596, Goldsmith L (ed.), Oxford University Press, Oxford, 1983.Google Scholar
  25. 25.
    Scheweizer J, Winter H: Keratin biosynthesis in normal mouse epithelia and in squamous cell carcinomas. J Biol Chem 258:13268, 1983.Google Scholar
  26. 26.
    Shaw J: Development of transdermal therapeutic systems. Drug Dev Ind Pharm 9:579, 1983.CrossRefGoogle Scholar
  27. 27.
    Stoughton RB, McClure WO: Azone: A new non-toxic enhancer of cutaneous penetration. Drug Dev Ind Pharm 9:725, 1983.CrossRefGoogle Scholar
  28. 28.
    Streilein JW: Skin-associated lymphoid tissues (SALT): Origins and functions. J Invest Dermatol 80:12s, 1983.Google Scholar
  29. 29.
    Traub W, Piez KA: The chemistry and structure of collagen. Adv Protein Chem 25:243, 1971.PubMedCrossRefGoogle Scholar
  30. 30.
    Wertz PW, Downing DT: Glycolipids in mammalian epidermis: Structure and function in the water barrier. Science 217:1261, 1982.PubMedCrossRefGoogle Scholar
  31. 31.
    Winter H, Schweizer J: Keratin synthesis in normal mouse epithelia and in squamous cell carcinomas: Evidence in tumors for masked RNA species coding for high molecular weight keratin polypeptides. Proc Natl Acad Sci USA 80:6480, 1983.PubMedCrossRefGoogle Scholar
  32. 32.
    Zettergren JG, Peterson LL, Wuepper KD: Keratolinin: The soluble substrate of epidermal transglutaminase from human and bovine tissue. Proc Natl Acad Sci USA 81:238, 1984.PubMedCrossRefGoogle Scholar

Recommended Readings

  1. Blank IH: Protective role of the skin. In: Dermatology in General Medicine, 3rd ed, p 337, Fitzpatrick TB, Eisen AZ, Wolff K, et al. (eds.), McGraw-Hill, New York, 1987.Google Scholar
  2. Bronaugh RL, Maibach HI (eds.): Percutaneous Absorption Mechanisms, Methodology and Drug Delivery, 2nd ed, Marcel Dekker, New York, 1989.Google Scholar

Copyright information

© Springer Science+Business Media New York 1992

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  • David R. Bickers

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