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The Role of Environmental Chemicals in Human Cancer Causation

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Book cover Principles and Practice of Environmental Medicine

Abstract

In 1775 Sir Percival Pott first defined the role of environmental chemicals as etiological agents in human cancer. Pott, a London surgeon, drew attention to the unique susceptibility of chimney sweeps to scrotal skin cancer (205). He attributed their increased cancer risk to chronic soot exposure. It is now appreciated, many years later, that soot contains chemical substances known as polycyclic aromatic hydrocarbons (PAHs), which are potent carcinogens. Among these PAHs is benzo[a]pyrene (BaP), a ubiquitous environmental pollutant found in cigarette smoke, automobile exhaust, and urban air. This substance has been demonstrated to be a potent skin carcinogen in experimental animals.

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  1. Howard M. Kipen
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  1. School of Medicine, University of California, San Francisco, California, USA

    Alyce Bezman Tarcher M.D.

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Kipen, H.M., Weinstein, I.B. (1992). The Role of Environmental Chemicals in Human Cancer Causation. In: Tarcher, A.B. (eds) Principles and Practice of Environmental Medicine. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2447-6_26

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