Disorders of the Hematopoietic System

  • William A. NewtonJr.
  • Alyce Bezman Tarcher


This chapter focuses on the relationship between exposure to environmental chemicals and physical agents and disorders of the hematopoietic system. The hematopoietic system includes the formed elements of the blood as well as the bone marrow, spleen, lymph nodes, and reticuloendothelial tissue. It is uniquely constructed to provide the body with a vast capacity for cell renewal. To balance the loss of mature cells and to provide for rapid expansion in response to bodily insults, cellular renewal must be maintained throughout life. The relative accessibility of the blood and bone marrow creates the potential for providing early clues to the effects of toxic exposure. A wide range of hematological disorders may follow exposure to such environmental agents as solvents, heavy metals, insecticides, nitrates, nitrites, and ionizing radiation (45, 77, 106, 126, 199, 211).


Chronic Lymphocytic Leukemia Aplastic Anemia Organochlorine Pesticide Blood Lead Level Hematological Disorder 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Recommended Readings

  1. Irons RD (ed.): Toxicology of the Blood and Bone Marrow, Raven Press, New York, 1985.Google Scholar
  2. Scott JL, Cartwright GE, Wintrobe MM: Acquired aplastic anemia: An analysis of thirty-nine cases and a review of the pertinent literature. Medicine 38:119, 1959.PubMedGoogle Scholar
  3. Sharp DS, Eskenazi B: Delayed health hazards of pesticide exposure. Annu Rev Public Health 7:441, 1986.PubMedGoogle Scholar
  4. Symposium on Benzene Metabolism, Toxicity and Carcinogenesis: Environ Health Perspect 82:1–344, 1989.Google Scholar
  5. Tsongas TA: Occupational factors in the epidemiology of chemically induced lymphoid and hemopoietic cancers. In: Toxicology of the Blood and Bone Marrow, p 149, Irons RD (ed.), Raven Press, New York, 1985.Google Scholar

Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • William A. NewtonJr.
  • Alyce Bezman Tarcher

There are no affiliations available

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