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Disorders of the Liver

  • Philip S. Guzelian
Chapter

Abstract

Very little is known about the clinical aspects of “environmental hepatology,” especially when compared to the extensive experimental investigations of the hepatotoxic effects of environmental agents. The very advantages that have made the liver popular as an organ for general studies of cell biology, biochemistry, and physiology also make the liver attractive for studies of the effects of potentially toxic substances.

Keywords

Vinyl Chloride Organochlorine Pesticide Liver Test Porphyria Cutanea Tarda Transpeptidase Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Agostini A, Ideo G, Stabilini R: Serum gamma-glutamyl transpeptidase activity in myocardial infarction. Br Heart J 27:688, 1965.CrossRefGoogle Scholar
  2. 2.
    Alcohol, HDL Cholesterol and liver microsomal induction. Lancet 1:8367, 1984.Google Scholar
  3. 3.
    Alvares AP, Fischbein A, Anderson MD, et al: Alterations in drug metabolism in workers exposed to poly-chlorinated biphenyls. Clin Pharmacol Ther 22:140, 1977.PubMedGoogle Scholar
  4. 4.
    Anderson HA, Wolff MS, Lilis R, et al: Symptoms and clinical abnormalities following ingestion of polybro-minated-biphenyl contaminated food products. Ann NY Acad Sci 320:684, 1979.PubMedGoogle Scholar
  5. 5.
    Axelson O: Solvents and the liver. Eur J Clin Invest 13: 109, 1983.PubMedCrossRefGoogle Scholar
  6. 6.
    Baker EL, Landrigan PJ, Glueck CJ, et al: Metabolic consequences of exposure to polychlorinated biphenyls (PCB) in sewage sludge. Am J Epidemiol 112:553, 1980.PubMedGoogle Scholar
  7. 7.
    Berk PD: Vinyl chloride-associated liver disease. Ann NY Acad Sci 84:717, 1976.Google Scholar
  8. 8.
    Blendis LM, Smith PM, Lawrie BW, et al: Portal hypertension in vinyl chloride monomer workers: A hemodynamic study. Gastroenterology 75:206, 1978.PubMedGoogle Scholar
  9. 9.
    Blumberg WE: Enzymic modification of environmental intoxicants: The role of cytochrome P-450. Q Rev Biophys 2:481, 1978.CrossRefGoogle Scholar
  10. 10.
    Breen KJ, Bury RW, Calder IV, et al: A [14C]phenacetin breath test to measure hepatic function in man. Hepa-tology 4:47, 1984.CrossRefGoogle Scholar
  11. 11.
    Breimer DD, Zilly W, Richter W: Influence of rifam-picin on drug metabolism: Differences between hexo-barbital and anti-pyrine. Clin Pharmacol Ther 21:470, 1977.PubMedGoogle Scholar
  12. 12.
    Burrows S, Feldman W, McBride F: Serum gamma glutamyl transpeptidase. Am J Clin Pathol 64:311, 1975.PubMedGoogle Scholar
  13. 13.
    Busachi C, Mebis J, Broeckaert L, et al: Histochemistry of 7-glutamyl transpeptidase in human liver biopsies. Pathol Res Pract 172:99, 1981.PubMedCrossRefGoogle Scholar
  14. 14.
    Chase K, Wong D, Thomas D, et al: Clinical and metabolic abnormalities associated with occupational exposure to polychlorinated biphenyls (PCBs). J Oc-cup Med 24:109, 1982.Google Scholar
  15. 15.
    Cohn WJ, Boylan ft Clanke RV, et al: Treatment of chlordecone (Kepone) toxicity with cholestyramine. N Engl J Med 298:243, 1978.PubMedCrossRefGoogle Scholar
  16. 16.
    Combes B, Shore GM, Cunningham FG, et al: Serum gamma-glutamyl transpeptidase activity in viral hepatitis suppression in pregnancy and by birth control pills. Gastroenterology 72:271, 1977.PubMedGoogle Scholar
  17. 17.
    Conney AH, Burns JJ: Metabolic interactions among environmental chemicals and drugs. Science 178:576, 1972.PubMedCrossRefGoogle Scholar
  18. 18.
    Cunningham JL, Evans DAP: Urinary D-glucaric acid excretion and acetanilide pharmacokinetics before and during diphenylhydantoin administration. Eur J Clin Pharmacol 7:387, 1974.PubMedCrossRefGoogle Scholar
  19. 19.
    Cushcieri A, Baker PR: Gamma-glutamyl-transpepti-dase in hepatobiliary disease—value as an enzymatic liver function test. Br J Exp Pathol 55:110, 1974.Google Scholar
  20. 20.
    Dossing M: Changes in hepatic microsomal enzyme function in workers exposed to mixtures of chemicals. Clin Pharmacol Ther 32:340, 1982.PubMedCrossRefGoogle Scholar
  21. 21.
    Dossing M, Arlien-Soborg P, Petersen LM, et al: Liver damage associated with occupational exposure to organic solvents in house painters. Eur J Clin Invest 13: 151, 1983.PubMedCrossRefGoogle Scholar
  22. 22.
    Ellis G, Worthy E, Goldberg DM: Lack of value of serum gamma-glutamyl transferase in the diagnosis of hepatobiliary disease. Clin Biochem 12:142, 1979.PubMedCrossRefGoogle Scholar
  23. 23.
    Emmelot P, Scherer E: The first relevant cell stage in rat liver carcinogenesis: A quantitative approach. Bio-chim Biophys Acta 605:247, 1980.Google Scholar
  24. 24.
    Farber E, Cameron R: The sequential analysis of cancer development. Adv Cancer Res 31:125, 1980.PubMedCrossRefGoogle Scholar
  25. 25.
    Fischbein AL, Wolff MS, Lilis R, et al: Clinical findings among PCB-exposed capacitor manufacturing workers. Ann NY Acad Sci 320:703, 1979.PubMedGoogle Scholar
  26. 26.
    Galteau MM, Siest G, Ratansavanh D: Effect of phenobarbital on the distribution of gamma-glutamyltrans-ferase between hepatocytes and nonparenchymal cells in the rat. Cell Mol Biol 26:267, 1979.Google Scholar
  27. 27.
    Gidlow DA, Church JF, Clayton BE: Haematological and biochemical parameters in an industrial workforce. Ann Clin Biochem. 20:341, 1983.PubMedGoogle Scholar
  28. 28.
    Guzelian PS: Environmental toxins and the liver. Pract Gastroenterol 5:26, 1981.Google Scholar
  29. 29.
    Guzelian PS: Comparative toxicology of chlordecone (Kepone) in humans and experimental animals. Annu Rev Pharmacol Toxicol 22:89, 1982.PubMedCrossRefGoogle Scholar
  30. 30.
    Guzelian PS, Vranian G, Boylan JJ et al: Liver structure and function in patients poisoned with chlordecone (Kepone). Gastroenterology 78:206, 1980.PubMedGoogle Scholar
  31. 31.
    Hedworth-Whitty RB, Whitfield JB, Richardson RW: Serum gamma-glutamyl transpeptidase activity in myocardial ischemia. Br Heart J 29:432, 1967.PubMedCrossRefGoogle Scholar
  32. 32.
    Hepner GW, Vesell ES: Assessment of aminopyrine metabolism in man by breath analysis after oral administration of 14C-aminopyrine: Effects of phenobarbital, disulfiram and portal cirrhosis. N Engl J Med 291:1384, 1974.PubMedCrossRefGoogle Scholar
  33. 33.
    Hernberg S, Kauppinen T, Riala R, et al: Increased risk for primary liver cancer among women exposed to solvents. Scand J Work Environ Health 14:356, 1988.PubMedCrossRefGoogle Scholar
  34. 34.
    Higuchi K (ed): PCB Poisoning and Pollution. Academic Press, New York, 1976.Google Scholar
  35. 35.
    Hirayama C, Irisa T, Tamamoto T: Fine structural changes of the liver in a patient with chloribiphenyls intoxication. Fukuoka Acta Med 60:455, 1969.Google Scholar
  36. 36.
    Hirayama C, Okumura M, Nagai J, et al: Hypobili-rubinemia in patients with polychlorinated biphenyls poisoning. Clin Chim Acta 55:97, 1974.PubMedCrossRefGoogle Scholar
  37. 37.
    Hoensch H, Andre M, Gruner J: Inducing effect of B-hexachlorocyclohexane (B-HCH) on human hepatic drug metabolism. Liver Metab Dis 76:15, 1982.Google Scholar
  38. 38.
    Horwitz CA, Burke MD, Henie W, et al: Late persistence of serum gamma-glutamyl transpeptidase activity after mononucleosis. Gastroenterology 72:1322, 1977.PubMedGoogle Scholar
  39. 39.
    Hosier J, Tschanz C, Hignite CE, et al: Topical application of lindane cream (Kwell) and antipyrine metabolism. J Invest Dermatol 74:51, 1979.Google Scholar
  40. 40.
    Hulka BS, Wilcosky TC, Griffith JD: Biological Markers in Epidemiology, Oxford University Press, Oxford, 1990.Google Scholar
  41. 41.
    Hunter J, Maxwell JD, Carrella M, et al: Urinary D-glucaric-acid excretion as a test for hepatic enzyme induction in man. Lancet 1:572, 1971.PubMedCrossRefGoogle Scholar
  42. 42.
    Hunter J, Maxwell JD, Stewart DA, et al: Increased hepatic microsomal enzyme activity from occupational exposure to certain organochlorine pesticides. Nature 237:399, 1972.PubMedCrossRefGoogle Scholar
  43. 43.
    Hunter J, Maxwell JD, Stewart DA, et al: Urinary D-glucaric acid excretion and total liver content of cytochrome P-450 in guinea pigs: Relationship during enzyme induction and following inhibition of protein synthesis. Biochem Pharmacol 22:743, 1973.PubMedCrossRefGoogle Scholar
  44. 44.
    Huseby NE: Subcellular localization of gamma-glut-amyltransferase activity in guinea pig liver. Effect of phenobarbital on the enzyme activity levels. Clin Chim Acta 94:163, 1979.PubMedCrossRefGoogle Scholar
  45. 45.
    Ideo G, Bellati G, Bellobuono A, et al: Increased urinary D-glucaric acid excretion by children living in an area polluted with tetrachlorodibenzoparadioxin (TCDD). Clin Chim Acta 120:273, 1982.PubMedCrossRefGoogle Scholar
  46. 46.
    Industrial solvents and the liver. Lancet 1:8316, 1983.Google Scholar
  47. 47.
    Jacobs WLW: Gamma-glutamyl-transpeptidase in diseases of the liver, cardiovascular system and diabetes mellitus. Clin Chim Acta 38:419, 1972.PubMedCrossRefGoogle Scholar
  48. 48.
    Kampa IS, Jarzabek J, Clain J: The use of gamma-glutamyl transpeptidase in differentiating liver from bone isoenzymes of alkaline phosphatase. Clin Biochem 9:234, 1976.PubMedCrossRefGoogle Scholar
  49. 49.
    Kato R: Drug metabolism under pathological and abnormal physiological states in animals and man. Xeno-biotica 7:25, 1977.CrossRefGoogle Scholar
  50. 50.
    Kew MC: The hepatitis-B virus and hepatocellular carcinoma. Semin Liver Dis 1:31, 1981.CrossRefGoogle Scholar
  51. 51.
    Kimbrough RD, Grandjean P: Occupational exposure. In: Halogenated Biphenyls, Terphenyls, Naphthalenes, Dibenzodioxins and Related Products, 2nd ed., p 485, Kimbrough RD, Jensen AA (eds.), Elsevier, Amsterdam, 1989.CrossRefGoogle Scholar
  52. 52.
    Knight JA, Haymond RE: Gamma-glutamyltransfer-ase and alkaline phosphatase activities compared in serum of normal children and children with liver disease. Clin Chem 27:48, 1981.PubMedGoogle Scholar
  53. 53.
    Kolmodin B, Azarnoff DL, Sjoqvist F: Effects of environmental factors on drug metabolism: Decreased plasma half-life of antipyrine in workers exposed to chlorinated hydrocarbon insecticides. Clin Pharmacol Ther 10:638, 1969.PubMedGoogle Scholar
  54. 54.
    Kopelman H, Scheuer P, Williams R: The liver lesion in Epping jaundice. Q J Med 35:553, 1966.Google Scholar
  55. 55.
    Kreiss K, Roberts C: Serial PBB levels, PCB levels, and clinical chemistries in Michigan’s PBB cohort. Arch Environ Health 37:141, 1982.PubMedCrossRefGoogle Scholar
  56. 56.
    Kreiss K, Zack MM, Kimbrough RD, et al: Cross-sectional study of a community with exceptional exposure to DDT. JAMA 245:1926, 1981.PubMedCrossRefGoogle Scholar
  57. 57.
    Kreiss K, Zack MM, Kimbrough RD, et al: Association of blood pressure and polychlorinated biphenyl levels. JAMA 245:2505, 1981.PubMedCrossRefGoogle Scholar
  58. 58.
    Kuratsune M, Shapiro RE (eds.): PCB Poisoning in Japan and Taiwan, Alan R Liss, New York, 1984.Google Scholar
  59. 59.
    Kurppa K, Vainio H: Study design, liver disease and house painters’ exposure to organic solvents. Eur J Clin Invest 13:113, 1983.PubMedCrossRefGoogle Scholar
  60. 60.
    Lehmann D, Prentice M, Rosalki SB: Plasma gamma-glutamyltranspeptidase activity following renal transplantation. Am J Clin Invest 7:148, 1970.Google Scholar
  61. 61.
    Makk L, Creech JL, Whelan JG, et al: Liver damage and angiosarcoma in vinyl chloride workers. JAMA 230:64, 1974.PubMedCrossRefGoogle Scholar
  62. 62.
    Maroni M, Colombi A, Arbosti G, et al: Occupational exposure to polychlorinated biphenyls in electrical workers. II. Health effects. Br J Ind Med 38:55, 1981.PubMedGoogle Scholar
  63. 63.
    Marsteller HJ, Lelbach WK, Muler R, et al: Unusual Splenomegalic liver disease as evidenced by peritoneoscopy and guided liver biopsy among polyvinyl chloride production workers. Ann NY Acad Sci 246:95, 1975.PubMedCrossRefGoogle Scholar
  64. 64.
    McLean EK, Mattocks AR: Environmental liver injury: Plant toxins. In: Toxic Injury of the Liver (Part B), p 517, Färber E, Fisher M (eds.), Marcel Dekker, New York, 1980.Google Scholar
  65. 65.
    Mitchell JR, Zimmerman HJ, Ishak KG, et al: Isoniazid liver injury: Clinical spectrum, pathology and probable pathogenesis. Ann Intern Med 84:181, 1976.PubMedCrossRefGoogle Scholar
  66. 66.
    Morgan DP, Lin LI: Blood organochlorine pesticide concentrations, clinical hematology and biochemistry in workers occupationally exposed to pesticides. Arch Environ Contam Toxicol 7:423, 1978.PubMedCrossRefGoogle Scholar
  67. 67.
    Morgan DP, Roan CC: Liver function in workers having high tissue stores of chlorinated hydrocarbon pesticides. Arch Environ Health 21:14, 1974.CrossRefGoogle Scholar
  68. 68.
    Nagayama J, Masuda Y, Kuratsune M: Chlorinated dibenzofurans in Kanechlor and rice oil used by patients with “Yusho.” Fukuoka Acta Med 66:593, 1975.PubMedGoogle Scholar
  69. 69.
    Nebert DW, Eisen HJ, Hegishi M, et al: Genetic mechanisms controlling the induction of polysubstrate mono-oxygenase (P-450) activities. Annu Rev Pharmacol Toxicol 21:431, 1981.PubMedCrossRefGoogle Scholar
  70. 70.
    Orlowski M: The role of gamma-glutamyl transpeptidase in the internal diseases clinic. Arch Immunol Ther Exp 11:1, 1963.Google Scholar
  71. 71.
    Pazderova-Vejlupkova J, Lukas E, Nemcova M, et al: The development and prognosis of chronic intoxication by tetrachlordibenzo-p-dioxin in men. Arch Environ Health 36:5, 1981.PubMedCrossRefGoogle Scholar
  72. 72.
    Perera FP, Weinstein IB: Molecular epidemiology and carcinogen DNA adduct detection: New approaches to studies of human cancer causation. J Chron Dis 35: 581, 1982.PubMedCrossRefGoogle Scholar
  73. 73.
    Pitot HC: Fundamentals of Oncology, 3rd ed., Marcel Dekker, New York, 1986.Google Scholar
  74. 74.
    Pitot HC, Sirica AE: The stages of initiation and promotion in hepatocarcinogenesis. Biochim Biophys Acta 605:191, 1980.PubMedGoogle Scholar
  75. 75.
    Poland A, Smith D, Kuntzman R, et al: Effect of intensive occupational exposure to DDT on phenylbutazone and Cortisol metabolism in human subjects. Clin Pharmacol Ther 11:724, 1970.PubMedGoogle Scholar
  76. 76.
    Popper H, Gerber MA, Schaffner V, et al: Environmental hepatic injury in man. Prog Liver Dis 6:605, 1979.PubMedGoogle Scholar
  77. 77.
    Rapeport WG, Mclnnes GT, Thompson GG, et al: Hepatic enzyme induction and leucocyte delta-amino-laevulinic acid synthase activity: Studies with car-bamazepine. Br J Clin Pharmacol 16:133, 1983.PubMedCrossRefGoogle Scholar
  78. 78.
    Renner E, Wietholtz H, Huguenin P, et al: Caffeine: A model compound for measuring liver function. Hepa-tology 4:38, 1984.CrossRefGoogle Scholar
  79. 79.
    Rosalki SB, Rau D: Serum gamma-glutamyl transpeptidase activity in alcoholism. Clin Chim Acta 39:41, 1972.PubMedCrossRefGoogle Scholar
  80. 80.
    Rosalki SB, Tarlow D, Rau D: Plasma gamma-glutamyl transpeptidase elevation in patients receiving enzyme-inducing drugs. Lancet 2:376, 1971.PubMedCrossRefGoogle Scholar
  81. 81.
    Rutenberg AM, Goldbarg JA, Peneda FP: Plasma gamma-glutamyl transpeptidase. Clin Chem 15:124, 1969.Google Scholar
  82. 82.
    Schmid R: Cutaneous porphyria in Turkey. N Engl J Med 263:397, 1960.PubMedCrossRefGoogle Scholar
  83. 83.
    Selinger MJ, Matloff DS, Kaplan MM: 7-Glutamyl transpeptidase activity in liver disease: Serum elevation is independent of hepatic GGTP activity. Clin Chim Acta 125:283, 1982.PubMedCrossRefGoogle Scholar
  84. 84.
    Sirica AE, Wilkerson CS, Wu LL, et al: Evaluation of chlordecone in a two-stage model of hepatocarcinogenesis: A significant sex difference in the hepatocellular carcinoma incidence. Carcinogenesis 10:1047, 1989.PubMedCrossRefGoogle Scholar
  85. 85.
    Smith AB, Schloemer J, Lowry LK, et al: Metabolic and health consequences of occupational exposure to polychlorinated biphenyls. Br J Ind Med 39:361, 1982.PubMedGoogle Scholar
  86. 86.
    Smith PM, Crossley IR, Williams DMJ: Portal hypertension in vinyl-chloride production workers. Lancet 2:602, 1976.PubMedCrossRefGoogle Scholar
  87. 87.
    Snyder R, Remmer H: Classes of hepatic microsomal mixed function oxidase inducers. Pharmacol Ther 7: 203, 1979.PubMedCrossRefGoogle Scholar
  88. 88.
    Sotaniemi EA, Sutinen S, Sutinen S, et al: Liver injury in subjects occupationally exposed to chemicals in low doses. Acta Med Scand 212:207, 1982.PubMedCrossRefGoogle Scholar
  89. 89.
    Strik JJTWA, Koeman JH (eds.): Chemical Porphyria in Man, Elsevier, Amsterdam, 1979.Google Scholar
  90. 90.
    Tamburro CH, Greenberg R: Effectiveness of federally required medical laboratory screening in the detection of chemical liver injury. Environ Health Perspect 41: 117, 1981.PubMedCrossRefGoogle Scholar
  91. 91.
    Tazi A, Ratansavanh D, Galteau MM, et al: Hepatic membrane gamma-glutamyltransferase solubilization facilitated after administration of phenobarbital. Pharmacol Res Commun 11:211, 1979.PubMedCrossRefGoogle Scholar
  92. 92.
    Thomas LB; Vinyl-chloride-induced liver disease: From idiopathic portal hypertension (Banti’s syndrome) to angiosarcomas. N Engl J Med 292:17, 1975.PubMedCrossRefGoogle Scholar
  93. 93.
    Vrij-Standhardt WG, Strik JJTWA, Ottevanger CF, et al: Urinary D-glucaric acid and urinary total porphyrin excretion in workers exposed to endrin. In: Chemical Porphyria in Man, p 113, Strik JJTWA, Koe-man JE (eds.), Elsevier/North-Holland, Amsterdam, 1979.Google Scholar
  94. 94.
    Whitfield JB, Pounder RE, Neale G, et al: Serum 7-glutamyl transpeptidase activity in liver disease. Gut 13:702, 1972.PubMedCrossRefGoogle Scholar
  95. 95.
    Whitfield JB, Moss DW, Neale S, et al: Changes in plasma 7-glutamyl transpeptidase activity associated with alterations in drug metabolism in man. Br Med J 1:316, 1973.PubMedCrossRefGoogle Scholar
  96. 96.
    Williams DMJ, Smith DPM, Taylor KJ, et al: Monitoring liver disorders in vinyl chloride monomer workers using greyscale ultrasonography. Br J Ind Med 33:152, 1976.PubMedGoogle Scholar
  97. 97.
    Zimmerman HJ: Syndromes of environmental hepato-xicity. In: Hepatotoxicity, The Adverse Effects of Drugs and Other Chemicals on the Liver, p 279, Appleton-Century Crofts, New York, 1978.Google Scholar
  98. 98.
    Zimmerman HJ, Maddrey WC: Toxic and drug-induced hepatitis. In: Diseases of the Liver, p 591, Schiff L, Schiff ER (eds.), JB Lippincott, Philadelphia, 1987.Google Scholar

Recommended Readings

  1. Plaa GL, Hewitt WR (eds.): Toxicology of the Liver, Raven Press, New York, 1982.Google Scholar
  2. Zimmerman HJ, Maddrey WC: Toxic and drug-induced hepatitis. In: Diseases of the Liver, p 591, Schiff L, Schiff ER (eds.), JB Lippincott, Philadelphia, 1987.Google Scholar

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© Springer Science+Business Media New York 1992

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  • Philip S. Guzelian

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