Abstract
Heparan sulfate (HS) proteoglycans are widely distributed throughout animal tissues in two main localized areas; in association with the plasma membrane and in the extracellular matrix (especially in basement membranes). Discussions on the metabolism of plasma membrane-associated HS proteoglycans is the subject of this chapter.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
D. M. Noonan, E. A. Horigan, S. R. Ledbetter, G. Vogeli, M. Sasaki, Y. Yamada, and J. R. Hassell, Identification of cDNA clones encoding different domains of the basement membrane heparan sulfate proteoglycan, J. Biol. Chem. 263:16379 (1988).
S. Saunders, M. Jalkanen, S. O’Farrell and M. Bernfield, Molecular cloning of syndecan, an integral membrane proteoglycan, J. Cell Biol. 18:1547 (1989).
P. J. Marynen, J. Zhang, J. J. Cassiman, H. Van den Berghe and G. David, Partial primary structure of 48-and 90-kilodalton core proteins of cell surface-associated heparan sulfate proteoglycans of lung fibroblasts, J. Biol. Chem. 264:7017 (1989).
G. David, V. Lories, B. Marynen, J.-J. Cassiman, and H. Van den Berghe, Molecular cloning of a phosphatidylinositol-anchored membrane heparan sulfate proteoglycan from human lung fibroblasts, J. Cell Biol. 111:3165 (1990).
Y. Takeuchi, K. Sakaguchi, M. Yanagishita, G. D. Aurbach and V. C. Hascall, Extracellular calcium regulates transport and distribution of proteoglycans in a rat parathyroid cell line, J. Biol. Chem. 265:13661 (1990).
M. Ishihara, N. S. Fedarko, and H. E. Conrad, Involvement of phosphatidylinositol and insulin in the coordinated regulation of proteoheparan sulfate metabolism and hepatocyte growth, J. Biol. Chem. 262:4708 (1987).
M. Yanagishita and D. J. McQuillan, Two forms of plasma membrane-intercalated heparan sulfate proteoglycans in rat ovarian granulosa cells: labeling of proteoglycans with a photoactivatable hydrophobic probe, and effect of membrane-anchor specific phospholipase C, J. Biol. Chem. 264:17551 (1989)
M. Yanagishita, Metabolic labeling of glycosylphosphatidylinositol-anchor of heparan sulfate proteoglycans in rat ovarian granulosa cells, submitted (1991).
D. J. Carey, D. M. Crumbling, R. C. Stahl, and D. M. Evans, Association of cell surface heparan sulfate proteoglycans of Schwann cells with extracellular matrix proteins, J. Biol. Chem. 265:20627 (1990).
A. Schmidtchen, R. Sundler, and L.-Å. Fransson, A fibroblast heparan sulphate proteoglycan with a 70 kDa core protein is linked to membrane phosphatidylinositol, Glycoconjugate J. 7:563, (1990).
L. Kjellén; Å. Oldberg; M. Höök, Cell-surface heparan sulfate: Mechanisms of proteoglycan-cell association, J. Biol. Chem. 255:10407 (1980)
E. F. Neufeld and J. Muenzer, The mucopolysaccharidoses, in: “The Metabolic Basis of Inherited Disease,” C. R. Scriver, A. L. Beaudet, W. S. Sly and D. Valle, eds. McGraw-Hill, New York, pp. 1565–1587 (1989).
M. Yanagishita, and V. C. Hascall, Proteoglycan synthesized by rat ovarian granulosa cell culture: multiple intracellular degradation pathways and the effect of chloroquine, J. Biol. Chem. 259:10270 (1984).
M. Yanagishita, and V. C. Hascall, Effects of monensin on the synthesis, transport and intracellular degradation of proteoglycans in rat ovarian granulosa cells in culture, J. Biol. Chem. 260:5445 (1985).
M. Yanagishita, Inhibition of intracellular degradation of proteoglycans by leupeptin in rat ovarian granulosa cells, J. Biol. Chem. 260:11075 (1985).
M. Yanagishita, Glycosylphosphatidylinositol-anchored and core protein intercalated heparan sulfate proteoglycans in rat ovarian granulosa cells have distinct secretory, endocytotic and intracellular degradation pathways submitted (1991).
D. J. McQuillan, R. J. Midura, V. C. Hascall and M. Yanagishita, Plasma membrane-intercalated heparan sulfate proteoglycans in osteoblastic cell line (UMR 106-01, BSP), submitted.
B. L. Chan, M. P. Lisanti, E. Rodriguez-Boulan and A. R. Saltiel, Insulin-stimulated release of lipoprotein lipase by metabolism of its phosphatidylinositol anchor, Science 241:1670 (1988)
H. Hausser and H. Kresse, Binding of heparin and of the small proteoglycan decorin to the same endocytosis receptor proteins leads to different metabolic consequences, J. Cell Biol. 114:45 (1991)
G. M. Oosta, L. V. Favreau, D. L. Beeler and R. D. Rosenberg, Purification and properties of human platelet heparitinase, J. Biol. Chem. 257:11249, (1982).
L. Thunberg, G. Bäckström, Å. Wasteson, H. C. Robinson, S. ögren and U. Lindahl, Enzymatic depolymerization of heparin-related polysaccharides: substrate specificities of mouse mastocytoma and human platelet endo-β-D-glucuronidases, J. Biol. Chem. 257:10278 (1982).
Å. Oldberg, C.-H. Heldin, Å. Wasteson, C. Busch and M. Höök, Characterization of a platelet endoglycosidase degrading heparin-like polysaccharides, Biochemistry 19:5755 (1980).
U. Klein and K. von Figura, Substrate specificity of a heparan sulfate-degrading endoglucuronidase from human placenta, Hoppe-Seyler’s Z. Phyiol. Chem. 360:1465 (1979).
M. Höök, Å. Wasteson and Å. Oldberg, A heparan sulfate-degrading endoglycosidase from rat liver tissue, Biochem. Biophys. Res. Commun. 67:1422 (1975).
U. Klein, H. Kresse and K. von Figura, Evidence for degradation of heparan sulfate by endoglycosidases: Glucosamine and hexuronic acid are reducing terminals of intracellular heparan sulfate from human skin fibroblasts, Biochem. Biophys. Res. Commun. 69:158 (1976).
L. Kjellén, H. Pertoft, Å. Oldberg and M. Höök, Oligosaccharides generated by an endoglucuronidase are intermediates in the intracellular degradation of heparan sulfate proteoglycans, J. Biol. Chem. 260:8416 (1985).
J. T. Gallagher, A. Walker, M. Lyon, and W. H. Evans, Heparan sulphate-degrading endoglycosidase in liver plasma membranes, Biochem. J. 250:719 (1988).
M. Piepkorn, P. Hovingh, and A. Linker, Glycosaminoglycan free chains, external plasma membrane component from the membrane proteoglycans, J. Biol. Chem. 264:8662 (1989).
N. S. Fedarko and H. E. Conrad, A unique heparan sulfate in the nuclei of hepatocytes: structural changes with growth state of the cells, J. Cell Biol. 102:587 (1986)
M. Ishihara, N. S. Fedarko and H. E. Conrad, Transport of heparan sulfate into the nuclei of hepatocytes, J. Biol. Chem. 261:13575 (1986)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1992 Springer Science+Business Media New York
About this chapter
Cite this chapter
Yanagishita, M. (1992). Metabolism of Plasma Membrane-Associated Heparan Sulfate Proteoglycans. In: Lane, D.A., Björk, I., Lindahl, U. (eds) Heparin and Related Polysaccharides. Advances in Experimental Medicine and Biology, vol 313. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2444-5_12
Download citation
DOI: https://doi.org/10.1007/978-1-4899-2444-5_12
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4899-2446-9
Online ISBN: 978-1-4899-2444-5
eBook Packages: Springer Book Archive