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The Comparison of an Interim Tertiary Predicted Model of Bovine Thrombin and the X-Ray Structure of Human Thrombin

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The Design of Synthetic Inhibitors of Thrombin

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 340))

Abstract

The comparison of an interim computer model of the tertiary structure of the B-chain of bovine α-thrombin predicted by homology with α-chymotrypsin1 and the refined 1.9 Å structure of human alpha-thrombin2,3 is reported here. The refinement of the surface loops is incomplete, as (in the interest of demonstrating objectivity) modelling was stopped when completion of the X-ray crystallographic structure2 was announced. Modelling of the loops is now in progress.

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Author information

Authors and Affiliations

  1. Proteus Molecular Design Ltd., Proteus House 48 Stockport Road, Marple, Cheshire, SK6 6AB, UK

    E. Platt

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  1. E. Platt
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Editor information

Editors and Affiliations

  1. Thrombosis Research Institute, London, UK

    Goran Claeson , Michael F. Scully , Vijay V. Kakkar  & John Deadman , ,  & 

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© 1993 Springer Science+Business Media New York

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Platt, E. (1993). The Comparison of an Interim Tertiary Predicted Model of Bovine Thrombin and the X-Ray Structure of Human Thrombin. In: Claeson, G., Scully, M.F., Kakkar, V.V., Deadman, J. (eds) The Design of Synthetic Inhibitors of Thrombin. Advances in Experimental Medicine and Biology, vol 340. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2418-6_7

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  • DOI: https://doi.org/10.1007/978-1-4899-2418-6_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-2420-9

  • Online ISBN: 978-1-4899-2418-6

  • eBook Packages: Springer Book Archive

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