Abstract
Thrombin, an important enzyme in the blood coagulation system, cleaves four Arg-Gly peptide bonds in fibrinogen in order to form fibrin monomers, which form blood clots after polymerisation. In thrombosis the blood coagulation system is disturbed, resulting in an excess of blood clot formation. Thrombosis can be inhibited by inactivation of thrombin.
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© 1993 Springer Science+Business Media New York
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Jetten, W., Peters, J.A.M., Visser, A., Grootenhuis, P.D.J., Ottenheijm, H.C.J. (1993). Transition State Analogue Inhibitors of Thrombin: Synthesis, Activity and Molecular Modelling. In: Claeson, G., Scully, M.F., Kakkar, V.V., Deadman, J. (eds) The Design of Synthetic Inhibitors of Thrombin. Advances in Experimental Medicine and Biology, vol 340. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2418-6_17
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DOI: https://doi.org/10.1007/978-1-4899-2418-6_17
Publisher Name: Springer, Boston, MA
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