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Aspergillosis

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Fungal Infections and Immune Responses

Part of the book series: Infectious Agents and Pathogenesis ((IAPA))

Abstract

Aspergillosis has been used to describe a group of disparate diseases that runs the gamut of clinical presentations from allergy to colonization to invasive disease to intoxication and that has in common being caused by members of the genus Aspergillus or their metabolites.

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References

  1. Kwon-Chung, K. J., 1988, Aspergillus: Diagnosis and description of the genus, in: Aspergillus and Aspergillosis (H. V. Bossche, D. W. R. Mackenzie, and G. Cauwenbergh, eds.), Plenum Press, New York, pp. 11–21.

    Google Scholar 

  2. Joseph, J. M., 1983, Aspergillosis in composting, in: Occupational Mycoses ( A. F. DiSalvo, ed.), Lea and Febiger, Philadelphia, pp. 123–141.

    Google Scholar 

  3. Allo, M. D., Miller, J., Townsend, T., and Tan, C., 1987, Primary cutaneous aspergillosis associated with Hickman intravenous catheters, N. Engl. J Med. 317: 1105–1108.

    Article  PubMed  CAS  Google Scholar 

  4. Magid, M. L., Prendiville, J. S., and Esterly, N. B., 1988, Violaceous nodules on the arm of a child with acute lymphocytic leukemia: Primary cutaneous aspergillosis (Aspergillus flavus), Arch. Dermatol. 124: 122–126.

    Article  PubMed  CAS  Google Scholar 

  5. Hay, R. J., 1988, Pulmonary aspergillosis: The clinical spectrum, in: Aspergillus and Aspergillosis ( H. V. Bossche, D. W. R. Mackenzie, and G. Cauwenbergh, eds.), Plenum Press, New York, pp. 97–105.

    Google Scholar 

  6. Young, R. C., Bennett, J. B., Vogel, C. L., Carbone, P. P., and DeVita, V. T., 1970, Aspergillosis: The spectrum of the disease in 98 patients, Medicine 49: 147–173.

    Article  PubMed  CAS  Google Scholar 

  7. Starke, I. D., and Keal, E. E., 1980, Cerebral aspergilloma in a patient with allergic bronchopulmonary aspergillosis, Br. J. Dis. Chest. 74: 301–305.

    Article  PubMed  CAS  Google Scholar 

  8. Kurup, V. P., Barboriak, J. J., and Fink, J. N., 1984, Hypersensitivity pneumonitis, in: Mould Allergy ( Y. Al-Doory and J. F. Domson, eds.), Lea and Febiger, Philadelphia, pp. 216–243.

    Google Scholar 

  9. Glimp, R. A., and Bayer, A. S., 1981, Fungal pneumonias (part 3): Allergic bronchopulmonary aspergillosis, Chest 80: 85–94.

    Article  PubMed  CAS  Google Scholar 

  10. Hoehne, J. H., Reed, C. E., and Dickie, H. A., 1973, Allergic bronchopulmonary aspergillosis is not rare: With a note on preparation of antigen for immunologic tests, Chest 63: 177–181.

    Article  PubMed  CAS  Google Scholar 

  11. Patterson, R., Greenberger, P. A., Radin, R. C., and Roberts, M., 1982, Allergic bronchopulmonary aspergillosis: Staging as an aid to management, Arch. Intern. Med. 96: 286–291.

    Article  CAS  Google Scholar 

  12. Jonathan, D., Lund, V., and Milroy, C., 1989, Allergic aspergillus sinusitis: An overlooked diagnosis? J. Laryngol. Otol. 103: 1181–1183.

    Article  PubMed  CAS  Google Scholar 

  13. De Coster, A., Dierckx, P., and Grivignee, A., 1988, Aspergilloma, in: Aspergillus and Aspergillosis (H. V. Bossche, D. W. R. Mackenzie, and G. Cauwenbergh, eds.), Plenum Press New York, pp. 107–114.

    Google Scholar 

  14. Albelda, S. M., Talbot, G. H., Gerson, S. L., Miller, W. T., and Cassileth, P. A., 1985, Pulmonary cavitation and massive hemoptysis in invasive pulmonary aspergillosis: influence of bone marrow recovery in patients with acute leukemia, Am. Rev. Respir. Dis. 131: 115–120.

    Google Scholar 

  15. Pena, C. E., 1975, Aspergillus intranasal fungus ball, Am. J. Clin. Pathol. 64: 343–344.

    PubMed  CAS  Google Scholar 

  16. Aisner, J., Murillo, J., Schmipff, S. C., and Steere, A. C., 1979, Invasive aspergillosis in acute leukemia: Correlation with nose cultures and antibiotic use, Ann. Intern. Med. 90: 4–9.

    Article  PubMed  CAS  Google Scholar 

  17. Gustafson, T. L., Schaffner, W, Lavely, G. B., Stratton, C. W, Johnson, H. K., and Hutcheson, R. H., Jr., 1983, Invasive aspergillosis in renal transplant recipients: Correlation with corticosteroid therapy, J. Infect. Dis. 148: 230–238.

    CAS  Google Scholar 

  18. Gerson, S. L., Talbot, G. H., Hurwitz, S., Strom, B. L., Lusk, E. J., and Cassileth, P. A., 1984, Prolonged granulocytopenia: The major risk factor for invasive pulmonary aspergillosis in patients with acute leukemia, Ann, Intern. Med. 100: 345–351.

    Article  CAS  Google Scholar 

  19. Rhodes, J. C., and Koelliker, D. D., 1993, Pathologic and laboratory aspects of aspergillosis, in: Progress in Infectious Diseases ( R. Genta, ed.), Field and Wood Medical Publishers, Philadelphia. In press.

    Google Scholar 

  20. Peterson, D. E., and Schmipff, S. C., 1989, Aspergillus sinusitis in neutropenic patients with cancer: A review, Biomed. Pharmacother. 43 :307–312.

    Google Scholar 

  21. Gefter, W. B., Weingrad, T. R., Epstein, D. M., Ochs, R. H., and Miller, W. T., 1981, “Semi-invasive” pulmonary aspergillosis: A new look at the spectrum of Aspergillus infections of the lung, Radiology 140:313–321.

    Google Scholar 

  22. Binder, R. E., Faling, L. J., Pugatch, R. D., Mahasaen, C., and Snider, G. L., 1982, Chronic necrotizing pulmonary aspergillosis: A discrete clinical entity, Medicine 61: 109–124.

    Article  PubMed  CAS  Google Scholar 

  23. Krishnamachari, K. A. V. R., Bhat, R. V., Nagarajan, V., and Tilak, T. B. G., 1975, Hepatitis due to aflatoxicosis: An outbreak in western India, Lancet 1 (May 10): 1061–1063.

    Article  PubMed  CAS  Google Scholar 

  24. van Rensburg, S. J., van Schalkwyk, G. C., and van Schalkwyk, D. J., 1990, Primary liver cancer and aflatoxin intake in Transkei J. Environ. Pathol. Toxicol. Oncol. 10 :11–16.

    Google Scholar 

  25. Autrup, H., Seremet, T., and Wakhisi, J., 1990, Evidence for human antibodies that recognize an aflatoxin epitope in groups with high and low exposure to aflatoxins Arch. Environ. Health. 45 :31–34.

    Google Scholar 

  26. Pestka, J. J., and Bondy, G. S., 1990, Alteration of immune function following dietary mycotoxin exposure, Can. J. Physiol. Pharmacol. 68: 1009–1016.

    Article  CAS  Google Scholar 

  27. Raper, K. B., and Fennell, D. I., 1965, The Genus Aspergillus, Williams and Wilkins Company, Baltimore.

    Google Scholar 

  28. Rhodes, J. C., and Kwon-Chung, K. J., 1989, Identification of agents of systemic mycoses, in: Medical Mycology: A Practical Approach (E. G. V. Evans and M. D. Richardson, eds.), IRL Press, Oxford, pp. 141–170.

    Google Scholar 

  29. Herbert, P. A., and Bayer, A. S., 1981, Fungal pneumonia (part 4): Invasive pulmonary aspergillosis, Chest 80: 220–225.

    Article  PubMed  CAS  Google Scholar 

  30. Rinaldi, M. G., 1983, Invasive aspergillosis Rev. Infect. Dis. 5 :1061–1077.

    Google Scholar 

  31. Rhodes, J. C., 1988, Virulence factors in fungal pathogens Microbiolog. Sci. 5 :252–254.

    Google Scholar 

  32. Kothary, M. H., Chase, T., Jr., and Macmillan, J. D., 1984, Correlation of elastase production by some strains of Aspergillus fumigates with ability to cause pulmonary invasive aspergillosis in mice, Infect. Immun. 43: 320–325.

    Google Scholar 

  33. Rhodes, J. C., Bode, R. B., and McCuan-Kirsch, C. M., 1988, Elastase production by clinical isolates of Aspergillus Diag. Microbiol. Infect. Dis. 10 :165–170.

    Google Scholar 

  34. Robinson, B. W. S., Venaille, T. J., Mendis, A. H. W, and McAleer, R., 1990, Allergens as proteases: An Aspergillus fumigates proteinase directly induces human epithelial cell detachment, J Allergy Clin. Immunol. 86: 726–731.

    Article  PubMed  CAS  Google Scholar 

  35. i35. Piechura, J. E., Kurup, V. P., and Daft, L. J., 1990, Isolation and immunochemical characterization of fractions from membranes of Aspergillus fumigatus with protease activity, Can. j Microbiol. 36:33–41.

    Google Scholar 

  36. Mackenzie, D. W. R., 1988, Aspergillus in man, in: Aspergillus and Aspergillosis (H. V. Bossche, D. W. R. Mackenzie, and G. Cauwenbergh, eds.), Plenum Press, New York, pp. 1–8.

    Google Scholar 

  37. Sinski, J. T., 1975, The epidemiology of aspergillosis, in: The Epidemiology of Human Mycotic Diseases (Y. Al-Doory, ed.), Charles C. Thomas, Publisher, Springfield, pp. 210–226.

    Google Scholar 

  38. 38. Nolard, N., Detandt, M., and Beguin, H., 1988, Ecology of Aspergillus species in the human environment, in: Aspergillus and Aspergillosis (H. V. Bossche, D. W. R. Mackenzie, and G. Cauwenbergh, eds.), Plenum Press, New York, pp. 35–41.

    Google Scholar 

  39. Walsh, T. J., and Dixon, D. M., 1989, Nosocomial aspergillosis: Environmental microbiology, hospital epidemiology, diagnosis and treatment, Eur. J. Epidemiol. 5: 131–142.

    Article  PubMed  CAS  Google Scholar 

  40. 40. Herman, L. G., 1980 Aspergillus in patient case areas, Ann. N.Y. Acad. Sci. 353 :140–146.

    Google Scholar 

  41. Meyers, J. D., 1990, Fungal infections in bone marrow transplant patients, Semin. Oncol. 17 (Suppl. 6): 10–13.

    PubMed  CAS  Google Scholar 

  42. Cohen, M. S., Isturiz, R. E., Malech, H. L., Root, R. K., Wilfert, C. M., Gutman, L., and Buckley, R. H., 1981, Fungal infection in chronic granulomatous disease: The importance of the phagocyte in defense against fungi, Am. J. Med. 71: 59–66.

    Article  PubMed  CAS  Google Scholar 

  43. 43. Schaffner, A., Douglas, H., and Braude, A., 1982, Selective protection against conidia by mononuclear and against mycelia by polymorphonuclear phagocytes in resistance to Aspergillus: Observations on these two lines of defense in vivo and in vitro with human and mouse phagocytes J. Clin. Invest. 69 :617–631.

    Google Scholar 

  44. Merkow, L. P., Epstein, S. M., Sidransky, H., Verney, E., and Pardo, M., 1971, The pathogenesis of experimental pulmonary aspergillosis: An ultrastructural study of alveolar macrophages after phagocytosis of A. flavus spores in vivo, Am. J. Pathol. 62: 58–74.

    Google Scholar 

  45. 45. Levitz, S. M., Selsted, M. E., Ganz, T., Lehrer, R. I., and Diamond, R. D., 1986 In vitro killing of spores and hyphae of Aspergillus fumigatus and Rhizopus oryzae by rabbit neutrophil cationic peptides and bronchoalveolar macrophages J. Infect. Dis. 154 :483–489.

    Google Scholar 

  46. 46. Diamond, R. D., Huber, E., and Haudenschild, C. C., 1983, Mechanisms of destruction of Aspergillus fumigatus hyphae mediated by human monocytes J Infect. Dis. 147 :474–483.

    Google Scholar 

  47. 47. Goodman, N. L., 1982, Aspergillosis Clin. Microbiol. Newsl. 4 :9–11.

    Google Scholar 

  48. 48. Batten, J., 1974, Clinical aspects of Aspergillus infections in man, in: Aspergillosis and Farmer’s Lung in Man and Animal (R. de Haller and E. Suter, eds.), Hans Huber Publishers, Bern, pp. 61–68.

    Google Scholar 

  49. 49. Fratamico, P. M., and Buckley, H. R., 1991, Identification and characterization of an immunodominant 58-kilodalton antigen of Aspergillus fumigatus recognized by sera of patients with invasive aspergillosis Infect. Immun. 59 :309–315.

    Google Scholar 

  50. 50. Lehman, P. E, and White, L. 0., 1976, Acquired immunity to Aspergillus fumigates Infect. Immun. 13 :1296–1298.

    Google Scholar 

  51. 51. Kim, S. J., and Chaparas, S. D., 1978, Characterization of antigens from Aspergillus fumigatus: Preparation of antigens from organisms grow in a completely synthetic medium, Am. Rev. Respir. Dis. 118 :547–551.

    Google Scholar 

  52. Chaparas, S. D., Morgan, P. A., Holobaugh, P., and Kim, S. J., 1986, Inhibition of cellular immunity by products of Aspergillus fumigatus, j Med. Vet. Mycol. 24: 67–76.

    Article  PubMed  CAS  Google Scholar 

  53. 53. Williams, D. W, Weiner, M. H., and Drutz, D. J., 1981, Immunologic studies of disseminated infection with Aspergillus fumigatus in the nude mouse J. Infect. Dis. 143 :726–733.

    Google Scholar 

  54. Denning, D. W, Follansbee, S. E., Scolaro, M., Norris, S., Edelstein, H., and Stevens, D. A., 1991, Pulmonary aspergillosis in the acquired immunodeficiency syndrome, N. Engl. J Med. 324: 654–662.

    Article  PubMed  CAS  Google Scholar 

  55. 55. Mullbacher, A., Waring, P., and Eichner, R. D., 1985, Identification of an agent in cultures of Aspergillus fumigates displaying anti-phagocytic and immunomodulating activity in vitro J. Gen. Microbiol. 131 :1251–1258.

    Google Scholar 

  56. 56. Arruda, L. K., Platts-Mills, T. A., Fox, J. W, and Chapman, M. D., 1990 Aspergillus fumigates allergen I, a major IgE-binding protein, is a member of the mitogillin family of cytotoxins J. Exp. Med. 172 :1529–1532.

    Google Scholar 

  57. 57. Washburn, R. G., Hammer, C. H., and Bennett, J. E., 1986, Inhibition of complement by culture supernatants of Aspergillus fumigatus J. Infect. Dis. 154 :944–951.

    Google Scholar 

  58. 58. Washburn, R. G., DeHart, D. J., Agwu, D. E., Bryant-Varela, B. J., and Julian, N. C., 1990 Aspergillus fumigatus complement inhibitor: Production, characterization, and purification by hydrophobic interaction and thin-layer chromatography Infect Immun. 58 :3508–3515.

    Google Scholar 

  59. 59. de Repentigny, L., and Reiss, E., 1984, Current trends in immunodiagnosis of candidiasis and aspergillosis Rev. Infect. Dis. 6 :301–312.

    Google Scholar 

  60. 60. Bernstein, J. A., Zeiss, C. R., Greenberger, P. A., Patterson, R., Marhoul, J. E, and Smith, L. L., 1990, Immunoblot analysis of sera from patients with allergic bronchopulmonary aspergillosis: Correlation with disease activity J. Allergy Clin. Immunol. 86 :532–539.

    Google Scholar 

  61. 61. Harvey, C., Shaw, R. J., and Longbottom, J. L., 1987, Diagnostic specificity of a sandwich ELISA for Aspergillus-related diseases J. Allergy Clin. Immunol. 79:324–330.

    Google Scholar 

  62. 62. Dupont, B., Huber, M., Kim, S. J., and Bennett, J. E., 1987, Galactomannan antigenemia and antigenuria in aspergillosis: Studies in patients and experimentally infected rabbits J. Infect. Dis. 155:1–11.

    Google Scholar 

  63. 63. Bennett, J. E., Friedman, M. M., and Dupont, B., 1987, Receptor-mediated clearance of Aspergillus galactomannan J Infect. Dis. 155 :1005–1010.

    Google Scholar 

  64. Rogers, T. R., Haynes, K. A., and Barnes, R. A., 1990, Value of antigen detection in predicting invasive pulmonary aspergillosis, Lancet 336: 1210–1213.

    Article  PubMed  CAS  Google Scholar 

  65. 65. Schaffer, P. J., Medoff, G., and Kobayashi, G. S., 1979, Demonstration of antigenemia by radioimmunoassay in rabbits experimentally infected with Aspergillus J. Infect. Dis. 139 : 313–319.

    Google Scholar 

  66. 66. Weiner, M. H., 1980, Antigenemia detected by radioimmunoassay in systemic aspergillosis Ann. Intern. Med. 92 :793–796.

    Google Scholar 

  67. 67. Sabetta, J. R., Miniter, P., and Andriole, V. T., 1985, The diagnosis of invasive aspergillosis by an enzyme-linked immunosorbent assay for circulating antigen J. Infect. Dis. 152 :946–953.

    Google Scholar 

  68. 68. Wilson, E. V., Hearn, V. M., and Mackenzie, D. W. R., 1987, Evaluation of a test to detect circulating Aspergillus fumigatus antigen in a survey of immunocompromised patients with proven or suspected disease J. Med. Vet. Mycol. 25 :365–375.

    Google Scholar 

  69. 69. Haynes, K. A., Latge, J. P., and Rogers, T. R., 1990, Detection of Aspergillus antigens associated with invasive infection J. Clin. Microbiol. 28 :2040–2044.

    Google Scholar 

  70. 70. Yu, B., Niki, Y., and Armstrong, D., 1990, Use of immunoblotting to detect Aspergillus fumigatus antigen in sera and urine of rats with experimental aspergillosis J. Clin. Microbiol. 28 :1575–1579.

    Google Scholar 

  71. 71. Talbot, G. H., Weiner, M. H., Gerson, S. L., Provencher, M., and Hurwitz, S., 1987, Serodiagnosis of invasive aspergillosis in patients with hematologic malignancy: Validation of the Aspergillus fumigatus antigen radioimmunoassay J Infect. Dis. 155 :12–27.

    Google Scholar 

  72. 72. Wong, B., Brauer, K., Tsai, R. R., and Jayasimhulu, K., 1989, Increased amounts of the Aspergillus metabolite D-mannitol in tissue and serum of rats with experimental aspergillosis J. Infect. Dis. 160 :95–103.

    Google Scholar 

  73. Benoit, G., De Chauvin, M. E, Cordonnier, C., Astier, A., and Bernaudin, J.-E, 1985, Oxalic acid level in bronchoalveolar lavage fluid from patients with invasive pulmonary aspergillosis, Am. Rev. Respir. Dis. 132: 748–751.

    PubMed  CAS  Google Scholar 

  74. Patterson, R., Greenberger, P. A., Halwig, J. M., Liotta, J. L., and Roberts, M., 1986, Allergic bronchopulmonary aspergillosis: Natural history and classification of early disease by serologic and roentgenographic studies, Arch. Intern. Med. 146: 916–918.

    Article  PubMed  CAS  Google Scholar 

  75. Patterson, T. E, Miniter, P., and Andriole, V. T.,1990, Efficacy of fluconazole in experimental invasive aspergillosis, Rev. Infect. Dis. 12(Suppl. 3):S281—S285.

    Google Scholar 

  76. Dupont, B., 1990, Itraconazole therapy in aspergillosis: Study in 49 patients, J. Am. Acad. Dermatol. 23: 607–614.

    Article  PubMed  CAS  Google Scholar 

  77. Lopez-Berestein, G., 1989, Liposomal-amphotericin B in the treatment of systemic mycoses in patients with cancer, in: Diagnosis and Therapy of Systemic Fungal Infections ( K. Holmberg and R. D. Meyer, eds.), Raven Press, New York, pp. 159–166.

    Google Scholar 

  78. 78. Denning, D. W, Tucker, R. M., Hanson, L. H., and Stevens, D. A., 1990, Itraconazole in opportunistic mycoses: Cryptococcosis and aspergillosis j Am. Acad. Dermatol. 23 :602–607.

    Google Scholar 

  79. DenningD. W, Hanson, L. H., and Stevens, D. A., 1990, In vitro activity of saperconazole (R66 905) compared with amphotericin B and itraconazole against Aspergillus species Eur. j Clin. Microbiol. Infect. Dis. 9 :693–697.

    Google Scholar 

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Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, 45267-0529, USA

    Judith C. Rhodes

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  1. Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, 73190, Oklahoma City, Oklahoma, USA

    Juneann W. Murphy

  2. University of South Florida, Tampa, Florida, USA

    Herman Friedman

  3. University of Pisa, Pisa, Italy

    Mauro Bendinelli

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Rhodes, J.C. (1993). Aspergillosis. In: Murphy, J.W., Friedman, H., Bendinelli, M. (eds) Fungal Infections and Immune Responses. Infectious Agents and Pathogenesis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2400-1_15

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  • DOI: https://doi.org/10.1007/978-1-4899-2400-1_15

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