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Neural Mechanisms of Startle Behavior pp 287–351Cite as

The Mammalian Startle Response

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Abstract

One of the ultimate goals of neuroscience is to determine how the brain directs and changes behavior in man. Given the enormous complexity of this endeavor, an increasing number of neuroscientists have focused on invertebrates and lower vertebrates in an effort to simplify the problem. Eventually, however, it will be necessary to analyze the cellular basis of behavior in a complex mammalian brain. To approach the problem at this level, it would be useful to study a relatively simple behavior that can be elicited in mammals and that is sensitive to a variety of experimental treatments.

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References

  • Adams, L. M., and Geyer, M. A., 1981, Effects of 6-hydroxydopamine lesions of locus coeruleus on startle in rats, Psychopharmacology 73: 394–398.

    Article  PubMed  CAS  Google Scholar 

  • Aghajanian, G. K., and Haigler, H. J., 1976, Hallucinogenic indoleamines: Preferential action upon presynaptic serotonin receptors, Psychopharmacol. Commun. 1: 619–629.

    Google Scholar 

  • Aghajanian, G. K., and Sheard, M. H., 1968, Behavioral effects of midbrain raphe stimulation: Dependence on serotonin, Commun. Behay. Biol. 1: 37–41.

    Google Scholar 

  • Albert, D. J., and Richmond, S. E., 1976, Hyperreactivity and aggressiveness following infusion of local anesthetic into the lateral septum or surrounding structures, Behay. Biol. 18: 211–226.

    Article  CAS  Google Scholar 

  • Albert, D. S., and Wong, R. C. K., 1978, Hyperreactivity, muricide, and intraspecific aggression in the rat produced by infusion of local anesthetic into the lateral septum or surrounding areas, J. Comp. Physiol. Psycho!. 92: 1062–1073.

    Article  CAS  Google Scholar 

  • Anandam, N., Felegi, W., and Stern, J. M., 1980, In utero alcohol heightens juvenile reactivity, Pharmacol. Biochem. Behay. 13: 531–536.

    Article  CAS  Google Scholar 

  • Anden, N. E., Corrodi, H., Fuxe, K., Hokfelt, B., Hokfelt, T., Rydin, C., and Svensson, T., 1970, Evidence for a central noradrenaline receptor stimulation by clonidine, Life Sci. 9: 513–523.

    Article  PubMed  CAS  Google Scholar 

  • Anderson, D. C., Johnson, D., and Kempton, H., 1969a, Second-order fear conditioning as revealed through augmentation of a startle response: Part I, Psychonomic Sci. 16: 5–7.

    Google Scholar 

  • Anderson, D. C., Johnson, D., and Kempton, H., 1969b, Second-order fear conditioning as revealed through augmentation of a startle response: Part II, Psychonomic Sci. 16: 7–9.

    Google Scholar 

  • Armus, H. L., Carlson, H. R., Guinan, J. F., and Crowell, R. A., 1964, Effect of secondary reinforcement stimulus on the auditory startle response, Psychol. Rep. 14: 535–540.

    Article  Google Scholar 

  • Astrachan, D. I., and Davis, M., 1981, Spinal modulation of acoustic startle: The role of norepinephrine, serotonin and dopamine, Brain Res. 206: 223–228.

    Article  PubMed  CAS  Google Scholar 

  • Astrachan, D. I., Davis, M., and Gallager, D. W., 1983, Behavior and binding: Correlations between alpha-l-adrenergic stimulation of acoustic startle and alpha-l-adrenoceptor occupancy and number of rat lumbar spinal cord, Brain Res. 260: 81–90.

    Article  PubMed  CAS  Google Scholar 

  • Berg, K. M., 1973, Elicitation of acoustic startle in the human, Ph.D. thesis, University of Wisconsin.

    Google Scholar 

  • Blair, R., Liran, J., Cytryniak, H., Shizgal, P., and Amit, Z., 1978, Explosive motor behavior, rigidity, and periaqueductal grey lesions, Neuropharmacology 17: 205–210.

    Article  PubMed  CAS  Google Scholar 

  • Blair, R., Cytryniah, H., Shizgal, P., and Amit, Z., 1980, Heroin, but not levorphanol produces explosive motor behavior in naloxone-treated rats, Psychopharmacology 69: 313–314.

    Article  PubMed  CAS  Google Scholar 

  • Brady, J. V., and Nauta, W. J. H., 1953, Subcortical mechanisms in emotional behavior: Affective changes following septal forebrain lesions in the albino rat, J. Comp. Physiol. Psychol. 46: 339–346.

    Article  PubMed  CAS  Google Scholar 

  • Braff, D. L., and Geyer, M. A., 1980, Acute and chronic LSD effects on rat startle: Data supporting an LSD-rat model of schizophrenia, Biol. Psychiatr. 15: 909–916.

    CAS  Google Scholar 

  • Bridger, W. H., and Mandel, I. J., 1967, The effects of di-methoxy-phenylethylamine and mescaline on classical conditioning in rats as measured by the potentiated startle response, Life Sci. 6: 775–781.

    Article  PubMed  CAS  Google Scholar 

  • Brown, J. S., and Farber, I. E., 1968, Secondary motivation systems, Ann. Rev. Psychol. 19: 99–134.

    Article  CAS  Google Scholar 

  • Brown, J. S., Kalish, H. I., and Farber, I. E., 1951, Conditioned fear as revealed by magnitude of startle response to an auditory stimulus, J. Exp. Psychol. 41: 317–327.

    Article  PubMed  CAS  Google Scholar 

  • Brown, J. S., McRyman, J. W., and Marzocco, F. N., 1956, Sound-induced startle response as a function of time since shock, J. Comp. Physiol. Psychol. 49: 190–194.

    Article  PubMed  CAS  Google Scholar 

  • Bunney, B. S., Walters, J. R., Kuhar, M. J., Roth, R. H., and Aghajanian, G. K., 1975, D & L amphetamine stereoisomers: Comparative potencies in affecting the firing of central dopaminergic and noradrenergic neurons, Psychopharmacol. Commun. 1: 177–190.

    PubMed  CAS  Google Scholar 

  • Burnham, R. W., 1939, Repeated auditory stimulation of the startle response in the guinea pig, J. Psychol. 7: 79–89.

    Article  Google Scholar 

  • Capps, M. J., and Stockwell, C. W., 1968, Lesions in the midbrain reticular formation and the startle responses in rats, Physiol. Behay. 3: 661–665.

    Article  Google Scholar 

  • Carlsson, A., Ross, B. E., Walinder, J., and Skott, A., 1973, Further studies on the mechanisms of antipsychotic action: Potentiation by alpha-methyl tyrosine of thioridazine effects in chronic schizophrenia, J. Neural Trans. 34: 125–132.

    Article  CAS  Google Scholar 

  • Carlton, P. L., and Advokat, C., 1973, Attenuated habituation due to parachlorophenylalanine, Pharmacol. Biochem. Behay. 1: 657–663.

    Article  CAS  Google Scholar 

  • Chalmers, D. V., Hohf, J. C., and Levine, S., 1974, The effects of prior aversive stimulation on the behavioral and physiological responses to intense acoustic stimuli in the rat, Physiol. Behay. 12: 711–718.

    Article  CAS  Google Scholar 

  • Chi, C. C., 1965, The effect of amobarbital sodium on conditioned fear as measured by the potentiated startle response in rats, Psychopharmacologia 7: 115–122.

    Article  PubMed  CAS  Google Scholar 

  • Cladel, C. E., Cho, M. H., and McDonald, R. D., 1966, Effects of amphetamine and catecholamines on startle response and general motor activity in albino rats, Nature 210: 864–865.

    Article  CAS  Google Scholar 

  • Cohen, L. H., 1929, The relationship between refractory period and negative adaptation in reflex responses, J. Comp. Psychol. 9: 1–16.

    Article  Google Scholar 

  • Commissaris, R. L., and Davis, M., 1982, Opposite effects of N,N-dimethyltryptamine (DMT) and 5-methoxy-N,N-dimethyltryptamine (5-McODMT) on acoustic startle: Spinal vs. brain sites of action, Neurosci. Biobehay. Rev. 6: 515–520.

    Article  CAS  Google Scholar 

  • Conner, R. L., Stolk, J. M., Barchas, J. D., and Levine, S., 1970, Parachlorophenylalanine and habituation to repetitive auditory startle stimuli in rats, Physiol. Behay. 5: 1215–1219.

    Article  CAS  Google Scholar 

  • Cook, L., and Sepinwall, J., 1975, Behavioral analysis of the effects and mechanisms of action of benzodiazepines, in: Mechanisms of Action of Benzodiazepines ( E. Costa and P. Greengard, eds.), Raven Press, New York, pp. 1–28.

    Google Scholar 

  • Coover, G. D., and Levine, S., 1972, Auditory startle response of hippocampectomized rats, Physiol. Behay. 9: 75–78.

    Article  CAS  Google Scholar 

  • Davis, M., 1970a, Effects of interstimulus interval length and variability on startle response habituation in the rat, J. Comp. Physiol. Psychol. 72: 177–192.

    Article  PubMed  CAS  Google Scholar 

  • Davis, M., 1970b, Interstimulus interval and startle response habituation with a “control” for total time during training, Psychonomic Sci. 20: 39–41.

    Google Scholar 

  • Davis, M., 1972, Differential rates of decay of sensitization and habituation of the startle response in the rat, J. Comp. Physiol. Psychol. 78: 260–267.

    Article  PubMed  CAS  Google Scholar 

  • Davis, M., 1974a, Signal-to-noise ratio as a predictor of startle amplitude and habituation in the rat, J. Comp. Physiol. Psychol. 86: 812–825.

    Article  PubMed  CAS  Google Scholar 

  • Davis, M., 1974b, Sensitization of the rat startle response by noise, J. Comp. Physiol. Psychol. 87: 571–581.

    Article  PubMed  CAS  Google Scholar 

  • Davis, M., 1979a, Diazepam and flurazepam: Effects on conditioned fear as measured with the potentiated startle paradigm, Psychopharmacology 62: 1–7.

    Article  PubMed  CAS  Google Scholar 

  • Davis, M., 19796, Morphine and naloxone: Effects on conditioned fear as measured with the potentiated startle paradigm, Eur. J. Pharmacol. 54: 341–347.

    Google Scholar 

  • Davis, M., 1981, Habituation and sensitization of a startle-like response elicited by electrical stimulation at different points in the acoustic startle circuit, Adv. Physiol. Sci. 16: 67–78.

    CAS  Google Scholar 

  • Davis, M., and Aghajanian, G. K., 1976, Effects of apomorphine and haloperidol on the acoustic startle response, Psychopharmacology 47: 217–223.

    Article  PubMed  CAS  Google Scholar 

  • Davis, M., and Astrachan, D. I., 1978, Conditioned fear and startle magnitude: Effects of different footshock or backshock intensities used in training, J. Exp. Psychol. Anim. Behay. Process. 4: 95–103.

    Article  CAS  Google Scholar 

  • Davis, M., and Astrachan, D. I., 1981, Spinal modulation of acoustic startle: Opposite effects of clonidine and d-amphetamine, Psychopharmacology 75: 219–225.

    Article  PubMed  CAS  Google Scholar 

  • Davis, M., and Bear, H. D., 1972, Effects of N,N-dimethyltryptamine on retention of startle habituation in the rat, Psychopharmacologia 27: 29–44.

    Article  PubMed  CAS  Google Scholar 

  • Davis, M., and File, S. E., 1984, Intrinsic and extrinsic habituation and sensitization: Implications for the design and interpretation of experiments, in: Habituation in the Behaving Organism ( H. V. S. Peeke and L. Petrinovich, eds.), Academic Press, New York, pp. 287–323.

    Google Scholar 

  • Davis, M., and Gendelman, P. M., 1977, Plasticity of the acoustic startle reflex in acutely decerebrate rats, J. Comp. Physiol. Psychol. 91: 549–563.

    Article  PubMed  CAS  Google Scholar 

  • Davis, M., and Heninger, G. R., 1972, Comparison of response plasticity between the eyeblink and vertex potential in humans, Electroenceph. Clin. Neurophysiol. 33: 283–293.

    Article  PubMed  CAS  Google Scholar 

  • Davis, M., and Sheard, M. H., 1974a, Habituation and sensitization of the rat startle response: Effects of raphe lesions, Physiol. Behay. 12: 425–431.

    Article  CAS  Google Scholar 

  • Davis, M., and Sheard, M. H., 1974b, Effects of lysergic acid diethylamide (LSD) on habituation and sensitization of the startle response in the rat, Pharmacol. Biochem. Behay. 2: 675–683.

    Article  CAS  Google Scholar 

  • Davis, M., and Sheard, M. H., 1974c, Biphasic dose-response effects of N,N-dimethyltryptamine on the rat startle reflex, Pharmacol. Biochem. Behay. 2: 827–829.

    Article  CAS  Google Scholar 

  • Davis, M., and Sheard, M. H., 1975, Effects of lysergic acid dietlrylamide (LSD) on temporal recovery (pre-pulse inhibition) of the acoustic startle response in the rat, Pharmacol. Biochem. Behay. 3: 861–868.

    Article  CAS  Google Scholar 

  • Davis, M., and Sheard, M. H., 1976, p-Chloroamphetamine (PCA): Acute and chronic effects on habituation and sensitization of the acoustic startle response in the rat, Eur. J. Pharmacol. 35: 261–273.

    Google Scholar 

  • Davis, M., and Wagner, A. R., 1968, Startle responsiveness following habituation to different intensities of tone, Psychonomic Sci. 12: 337–338.

    Google Scholar 

  • Davis, M., and Wagner, A. R., 1969, Habituation of the startle response under an incremental sequence of stimulus intensities, J. Comp. Physiol. Psychol. 67: 486–492.

    Article  PubMed  CAS  Google Scholar 

  • Davis, M., and Walters, J. R., 1977, Psilocybin: Biphasic dose response effects on the acoustic startle reflex in the rat, Pharmacol. Biochem. Behay. 6: 427–431.

    Article  CAS  Google Scholar 

  • Davis, M., and Zolovick, A. J., 1972, Habituation of the startle response in adrenalectomized rats, Physiol. Behay. 8: 579–584.

    Google Scholar 

  • Davis, M., Svensson, T. H., and Aghajanian, G. K., 1975, Effects of d- and t-amphetamine on habituation and sensitization of the acoustic startle response in rats, Psychopharmacologia 43: 1–11.

    Article  PubMed  CAS  Google Scholar 

  • Davis, M., Cedarbaum, J. M., Aghajanian, G. K., and Gendelman, D. S., 1977a, Effects of clonidine on habituation and sensitization of acoustic startle in normal, decerebrate and locus coeruleus lesioned rats, Psychopharmacology 51: 243–253.

    Article  PubMed  CAS  Google Scholar 

  • Davis, M., Gallager, D. W., and Aghajanian, G. K., 1977b, Tricyclic antidepressant drugs: Attenuation of excitatory effects of d-lysergic acid diethylamide (LSD) on the acoustic startle reflex, Life Sci. 20: 1249–1258.

    Article  PubMed  CAS  Google Scholar 

  • Davis, M., Redmond, D. E., Jr., and Baraban, J. M., 1979, Noradrenergic agonists and antagonists: Effects on conditioned fear as measured by the potentiated startle paradigm, Psychopharmacology 65: 111–118.

    Article  PubMed  CAS  Google Scholar 

  • Davis, M., Astrachan, D. I., Gendelman, P. M., and Gendelman, D. S., 1980a, 5-methoxyN,N-dimethyltryptamine: Spinal cord and brainstem mediation of excitatory effects on acoustic startle, Psychopharmacology 70: 123–130.

    Google Scholar 

  • Davis, M., Astrachan, D. I., and Kass, E., 1980b, Excitatory and inhibitory effects of serotonin on sensorimotor reactivity measured with acoustic startle, Science 209: 521–523.

    Article  PubMed  CAS  Google Scholar 

  • Davis, M., Gendelman, D. S., Tischler, M., and Gendelman, P. M., I982a, A primary acoustic startle circuit: Lesion and stimulation studies, J. Neurosci. 2: 791–805.

    Google Scholar 

  • Davis, M., Parisi, T., Gendelman, D. S., Tischler, M. D., and Kehne, J. H., 1982b, Habituation and sensitization of electrically elicited `startle’ reflexes, Science 218: 688–690.

    Article  PubMed  CAS  Google Scholar 

  • deMontigny, C., and Aghajanian, G. K., 1977, Preferential action of 5-methoxytryptamine and 5-methoxydimethyltryptamine on presynaptic serotonin receptors: A comparative iontophoretic study with LSD and serotonin, Neuropharmacology 16: 811–818.

    Article  CAS  Google Scholar 

  • Dodge, R., and Louttit, C. M., 1926, Modification of the pattern of the guinea pig’s reflex response to noise, J. Comp. Psychol. 3: 267–285.

    Article  Google Scholar 

  • Edwards, S. B., 1980, The deep cell layers of the superior colliculus: Their reticular characteristics and structural organization, in: The Reticular Formation Revisited ( J. A. Hobson and M. A. B. Brazier, eds.), Raven Press, New York, pp. 193–209.

    Google Scholar 

  • Faingold, C. L., Hoffman, W. E., and Skittsworth, J. D., Jr., 1981, Pentylenetetrazolinduced enhancement of reticular-formation auditory evoked potential and acoustic startle responses in the cat, Neuropharmacology 20: 787–790.

    Article  PubMed  CAS  Google Scholar 

  • Fechter, L. D., 1974a, Central serotonin involvement in the elaboration of the startle reaction in rats, Pharmacol. Biochem. Behay. 2: 161–172.

    Article  CAS  Google Scholar 

  • Fechter, L. D., 1974b, The effect of L-dopa, clonidine, and apomorphine on the acoustic startle reaction in rats, Psychopharmacologia 39: 331–344.

    Article  PubMed  CAS  Google Scholar 

  • Fechter, L. D., and Ison, J. R., 1972, The inhibition of the acoustic startle reaction in rats by food and water deprivation, Learn. Motivation 3: 109–124.

    Article  Google Scholar 

  • Fleshier, M., 1965, Adequate acoustic stimuli for startle reaction in cat, J. Comp. Physiol. Psychol. 60: 200–207.

    Article  Google Scholar 

  • Forbes, A., and Sherrington, C. S., 1914, Acoustic startle reflexes in the decerebrate cat, Am. J. Psychiatr. 35: 367–376.

    Google Scholar 

  • Fox, J. E., 1979, Habituation and prestimulus inhibition of the auditory startle reflex in decerebrate rats, Physiol. Behay. 23: 291–298.

    Article  CAS  Google Scholar 

  • Gallager, D. W., and Aghajanian, G. K., 1975, Effects of chlorimipramine and lysergic acid diethylamide on efflux of precursor-formed 3H-serotonin: Correlations with serotonergic impulse flow, J. Pharmacol. Exp. Ther. 193: 785–795.

    PubMed  CAS  Google Scholar 

  • Gallager, D. W., Kehne, J. H., Wakeman, E. A., and Davis, M., 1983, Developmental changes in pharmacological responsivity of the acoustic startle reflex: Effects of picrotoxin, Psychopharmacology 79: 87–93.

    Article  PubMed  CAS  Google Scholar 

  • Galvani, P. F., 1970, Air-puff elicited startle: Habituation over trials and measurement of a hypothetical emotional response, Behay. Res. Methods Instrumentation 2: 232–233.

    Article  Google Scholar 

  • Gendelman, P. M., 1979, The effect of psychotropic drugs on acoustic startle modulation in the decerebrate rat, M.D. thesis, Yale University School of Medicine.

    Google Scholar 

  • Geyer, M. A., 1975, Functional heterogeneity within neurotransmitter systems. Psychopharmacol. Commun. 1: 675–686.

    PubMed  CAS  Google Scholar 

  • Geyer, M. A., 1981, Effects of levonantradol on habituation of startle in rats, J. Clin. Pharm. 21: 2355–2395.

    Article  Google Scholar 

  • Geyer, M., Warbritton, A. J. D., Menkes, D. B., Zook, J. A., and Mandell, A. J., 1975, Opposite effects of intraventricular serotonin and bufotenin on rat startle responses, Pharmacol. Biochem. Behay. 3: 687–691.

    Article  CAS  Google Scholar 

  • Geyer, M. A., Puerto, A., Menkes, D. B., Segal, D. S., and Mandell, A. J., 1976, Behavioral studies following lesions of the mesolimbic and mesostriatal serotonergic pathways, Brain Res. 106: 257–270.

    Article  PubMed  CAS  Google Scholar 

  • Geyer, M. A., Peterson, L. R., Rose, G. J., Horwitt, D. D., Light, R. K., Adams, L. M., Zook, J. A. Hawkins, R. L., and Mandell, A. J., 1978, The effects of lysergic acid diethylamide and mescaline-derived hallucinogens on sensory-integrative function: Tactile startle, J. Pharmacol. Exp. Ther. 207: 837–847.

    PubMed  CAS  Google Scholar 

  • Geyer, M. A., Rose, G. J., and Peterson, L. R., 1979, Mescaline increases startle responding equally in normal and raphe-lesioned rats, Pharmacol. Biochem. Behay. 10: 293–298.

    Article  CAS  Google Scholar 

  • Geyer, M. A., Flicker, C. E., and Lee, E. H. Y., 1982, Effect of tactile startle on serotonin content of midbrain raphe neurons in rats, Behay. Brain Res. 4: 369–376.

    Article  CAS  Google Scholar 

  • Gibbins, R. J., Kalant, H., LeBlanc, A. E., and Clark, J. W., 1971, The effects of chronic administration of ethanol on startle thresholds in rats, Psychopharmacologia 19: 95–104.

    Article  PubMed  CAS  Google Scholar 

  • Gogan, P., 1970, The startle and orienting reactions in man. A study of their characteristics and habituation, Brain Res. 18: 117–135.

    Article  PubMed  CAS  Google Scholar 

  • Gottlieb, G., 1971, Ontogenesis of sensory function in birds and mammals, in: The Biopsychology of Development ( E. Tobach, L. R. Aronson, and E. Shaw, eds.), Academic Press, New York, pp. 67–129.

    Google Scholar 

  • Graham, F. K., 1975, The more or less startling effects of weak prestimulation, Psychophysiology 12: 238–248.

    Article  PubMed  CAS  Google Scholar 

  • Groves, P. M., and Thompson, R. F., 1970, A dual process theory, Psychol. Rev. 77: 419–450.

    Article  PubMed  CAS  Google Scholar 

  • Groves, P. M., Boyle, R. D., Welker, R. L., and Miller, S. W., 1974a, On the mechanism of prepulse inhibition, Physiol. Behay. 12: 367–375.

    Article  CAS  Google Scholar 

  • Groves, P. M., Wilson, C. J., and Boyle, R. D., 19746, Brain stem pathways, cortical modulation and habituation of the acoustic startle response, Behay. Biol. 10: 391–418.

    Google Scholar 

  • Haigler, H. J., and Aghajanian, G. K., 1973, Mescaline and LSD: Direct and indirect effects on serotonin-containing neurons in brain, Eur. J. Pharmacol. 21: 53–60.

    Article  PubMed  CAS  Google Scholar 

  • Haigler, H. J., and Aghajanian, G. K., 1974, Lysergic acid diethylamide and serotonin: A comparison of effects on serotonergic neurons and neurons receiving a serotonergic input, J. Pharmacol. Exp. Ther. 188: 688–699.

    PubMed  CAS  Google Scholar 

  • Hamilton, L. W., and Timmons, C. R., 1979, Maturation of startle reflex habituation in rats, Bull. Psychon. Sci. 14: 427–430.

    Google Scholar 

  • Hammond, G. R., 1973, Lesions of pontine and medullary reticular formation and prestimulation inhibition of the acoustic startle reaction in rats, Physiol. Behay. 10: 239–243.

    Article  CAS  Google Scholar 

  • Hammond, G. R., 1974, Frontal cortical lesions and prestimulus inhibition of the rats acoustic startle reaction, Physiol. Psychol. 2: 151–156.

    Google Scholar 

  • Hammond, G. R., and Ison, J. R., 1973, Stimulus-produced reflex inhibition in the rat during induction of and recovery from barbiturate anesthesia, J. Comp. Physiol. Psychol. 84: 436–444.

    Article  PubMed  CAS  Google Scholar 

  • Handley, S. L., and Thomas, K. V., 1979, Potentiation of startle response by d-and Iamphetamine: The possible involvement of pre-and postsynaptic alpha-adrenoceptors and other transmitter systems in the modulation of a tactile startle response, Psycho-pharmacology 64: 105–112.

    Article  CAS  Google Scholar 

  • Heninger, G. R., and Davis, M., 1979, Delayed effects of lithium on the somatosensory evoked response and the acoustic startle reflex in cats and monkeys, in: Lithium Controversies and Unresolved Issues ( S. Gershon, M. Schou, and N. S. Kline, eds.), Excerpta Medica, Amsterdam, pp. 841–853.

    Google Scholar 

  • Hoffman, H. S., and Fleshler, M., 1963, Startle reaction: Modification by background acoustic stimulation, Science 141: 928–930.

    Article  PubMed  CAS  Google Scholar 

  • Hoffman, H. S., and Ison, J. R., 1980, Reflex modification in the domain of startle. I. Some empirical findings and their implications for how the nervous system processes sensory input, Psychol. Rev. 87: 175–189.

    Article  PubMed  CAS  Google Scholar 

  • Hoffman, H. S., and Searle, J. L., 1965, Acoustic variables in the modification of the startle reaction in the rat, J. Comp. Physiol. Psycho!. 60: 53–58.

    Article  CAS  Google Scholar 

  • Hoffman, H. S., and Stitt, C., 1969, Behavioral factors in habituation of acoustic startle reactions, J. Comp. Physiol. Psychol. 68: 276–279.

    Article  PubMed  CAS  Google Scholar 

  • Hoffman, H. S., Fleshler, M., and Abplanalp, P. L., 1964, Startle reaction to electric shock in the rat, J. Comp. Physiol. Psychol. 58: 132–139.

    Article  PubMed  CAS  Google Scholar 

  • Horlington, M., 1968, A method for measuring acoustic startle response latency and magnitude in rats: Detection of a single stimulus effect using latency measurements, Physiol. Behay. 3: 839–844.

    Article  Google Scholar 

  • Ison, J. R., and Hammond, G., 1971, Modification of the startle reflex in the rat by changes in the auditory and visual environment, J. Comp. Physiol. Psychol. 75: 435–452.

    Article  PubMed  CAS  Google Scholar 

  • Ison, J. R., and Krauter, E. E., 1974, Reflex-inhibiting stimuli and the refractory period of the acoustic startle reflex in the rat, J. Comp. Physiol. Psychol. 86: 420–425.

    Article  PubMed  CAS  Google Scholar 

  • Ison, J. R., and Reiter, L. A., 1980, Reflex inhibition and reflex strength, Physiol. Psychol. 8: 345–350.

    Google Scholar 

  • Ison, J. R., and Silverstein, L., 1978, Acoustic startle reactions, activity and background noise intensity, before and after lesions of medial cortex in the rat, Physiol. Psychol. 6: 245–248.

    Google Scholar 

  • Ison, J. R., McAdam, D. W., and Hammond, G. R., 1973, Latency and amplitude changes in the acoustic startle reflex of the rat produced by variation in auditory prestimulation, Physiol. Behay. 10: 1035–1039.

    Article  CAS  Google Scholar 

  • Jacquet, Y. F., and Lajtha, A., 1973, Morphine action at central nervous system sites in rat: Analgesia or hyperalgesia depending on site and dose, Science 182: 490–492.

    Article  PubMed  CAS  Google Scholar 

  • Jacquet, Y. F., Klee, W. A., Rice, K. C., Iijima, I., and Minamihawa, J., 1977, Stereospecific and nonstereospecific effects of (+) and (—) morphine: Evidence for a new class of receptors, Science 198: 842–845.

    Article  PubMed  CAS  Google Scholar 

  • Jones, F. P., and Kennedy, J. L., 1951, An electromyographic technique for recording the startle pattern, J. Psychol. 32: 63–68.

    Article  Google Scholar 

  • Jordan, W. P., and Leaton, R. N., 1982a, Effects of mesencephalic reticular formation lesions on habituation of startle and lick suppression responses in rat, J. Comp. Physiol. Psychol. 96: 170–183.

    Article  PubMed  CAS  Google Scholar 

  • Jordan, W. P., and Leaton, R. N., 1982b, Startle habituation in rats after lesions in the brachium of the inferior colliculi, Physiol. Behay. 28: 253–258.

    Article  CAS  Google Scholar 

  • Kehne, J. H., 1983, The effects of clonidine on the flexor reflex in intact and spinalized rats, unpublished Ph.D. thesis, University of Massachusetts.

    Google Scholar 

  • Kehne, J. H., and Sorenson, C. A., 1978, Effects of pimozide and phenoxybenzamine pretreatments on amphetamine and apomorphine potentiation of the acoustic startle response in rats, Psychopharmacology 58: 137–144.

    Article  PubMed  CAS  Google Scholar 

  • Kehne, J. H., Gallager, D. W., and Davis, M., 1981, Strychnine: Brainstem and spinal mediation of excitatory effects on acoustic startle, Eur. J. Pharmacol. 76: 177–186.

    Article  PubMed  CAS  Google Scholar 

  • Kellogg, C. K., Tervo, D., Ison, J. R., Parisi, T., and Miller, R. K., 1980, Prenatal diazepam exposure alters behavioral development in rats, Science 207: 205–207.

    Article  PubMed  CAS  Google Scholar 

  • Kemble, E. D., and Ison, J. R., 1971, Limbic lesions and the inhibition of startle reactions in the rat by conditions of preliminary stimulation, Physiol. Behay. 7: 925–928.

    Article  CAS  Google Scholar 

  • Kirkby, R. J., Bell, D. S., and Preston, A. C., 1972, The effects of methylamphetamine on stereotyped behavior, activity, startle and orienting response, Psychopharmacologia 25: 41–48.

    Article  PubMed  CAS  Google Scholar 

  • Kokkinidis, L., and Anisman, H., 1978, Involvement of norepinephrine in startle arousal after acute and chronic d-amphetamine administration, Psychopharmacology 59: 285–292.

    Article  PubMed  CAS  Google Scholar 

  • Kokkinidis, L., and MacNeil, E. P., 1982, Stress-induced facilitation of acoustic startle after d-amphetamine administration, Pharmacol. Biochem. Behay. 17: 413–418.

    Article  CAS  Google Scholar 

  • Korn, J. H., and Moyer, K. E., 1965, The effects of pre-shock and handling on the startle response in the rat, Psychonomic Sci. 3: 409–410.

    Google Scholar 

  • Kurtz, K. H., and Siegel, A., 1966, Conditioned fear and magnitude of startle response: A replication and extension, J. Comp. Physiol. Psychol. 62: 8–14.

    Article  PubMed  CAS  Google Scholar 

  • Landis, C., and Hunt, W., 1939, The Startle Pattern, Farrar and Rinehart, New York.

    Google Scholar 

  • Larsson, L., 1956, The relation between the startle reaction and the non-specific EEG response to sudden stimuli with a discussion of the mechanism of arousal, Electroenceph. Clin. Neurophysiol. 8: 631–644.

    Article  PubMed  CAS  Google Scholar 

  • Leaton, R. N., 1976, Long-term retention of the habituation of lick suppression and startle response produced by a single auditory stimulus, J. Exp. Psychol. Anim. Behay. Process. 2: 248–259.

    Article  CAS  Google Scholar 

  • Leaton, R. N., 1981, Habituation of startle response, lick suppression, and exploratory behavior in rats with hippocampal lesions, J. Comp. Physiol. Psychol. 95: 813–826.

    Article  PubMed  CAS  Google Scholar 

  • Leitner, D. S., Powers, A. S., and Hoffman, H. S., 1980, The neural substrate of the startle response, Physiol. Behay. 25: 291–297.

    Article  CAS  Google Scholar 

  • Leitner, D. S., Powers, A. S., Stitt, C. L., and Hoffman, H. S., 1981, Midbrain reticular formation involvement in the inhibition of acoustic startle, Physiol. Behay. 26: 259–268.

    Article  CAS  Google Scholar 

  • McCall, R. B., and Aghajanian, G. K., 1979, Denervation supersensitivity to serotonin in the facial nucleus, Neuroscience 4: 1501–1510.

    Article  PubMed  CAS  Google Scholar 

  • Mackintosh, N. J., 1974, The Psychology of Animal Learning, Academic Press, London.

    Google Scholar 

  • Marlin, N. A., and Miller, R. R., 1981, Associations to contextual stimuli as a determinant of long-term habituation, J. Exp. Psychol. Anim. Behay. Process. 7: 313–333.

    Article  CAS  Google Scholar 

  • Marsh, R., Hoffman, H. S., and Stitt, C. L., 1973, Temporal integration in the acoustic startle reflex of the rat, J. Comp. Physiol. Psychol. 82: 507–511.

    Article  PubMed  CAS  Google Scholar 

  • Martin, M. R., 1980, The effects of iontophoretically applied antagonists on auditory nerve and amino acid evoked excitation of anteroventral cochlear nucleus neurons, Neuro-pharmacology 19: 519–528.

    CAS  Google Scholar 

  • Marwaha, J., Commissaris, R. L., Kehne, J. H., and Davis, M., 1982, The effects of intrathecal administration of clonidine on neuronal activity in nucleus locus coeruleus, Soc. Neurosci. Abst. 8: 726.

    Google Scholar 

  • Meier-Ewert, K., Gleitsmann, K., and Reiter, F., 1974, Acoustic jaw reflex in man: Its relationship to other brain stem and microreflexes, Electroenceph. Clin. Neurophysiol. 36: 629–638.

    Article  PubMed  CAS  Google Scholar 

  • Mellgren, R. L., 1969, Magnitude of the startle response and drive level, Psychol. Rep. 25: 187–193.

    Article  PubMed  CAS  Google Scholar 

  • Meryman, S. W., 1952, Magnitude of startle response as a function of hunger and fear, unpublished master’s thesis, University of Iowa.

    Google Scholar 

  • Miliaressis, T. E., and St. Laurent, J., 1974, Effets de lamide de lacid lysergique-25-sur la reaction de sursant chez le rat, Can. J. Physiol. Pharmacol. 52: 126–129.

    Article  PubMed  CAS  Google Scholar 

  • Miller, N. E., and Barry, H., III., 1960, Motivational effects of drugs: Methods which illustrate some general problems in psychopharmacology, Psychopharmacology 1: 169–199.

    Article  CAS  Google Scholar 

  • Miller, S. W., and Treft, R. L., 1979, Habituation of the acoustic startle response following lesions of the medial septal nucleus, Physiol. Behay. 23: 645–648.

    Article  CAS  Google Scholar 

  • Mortimer, J. A., 1973, Temporal sequence of cerebellar purkinje and reticular activity in relation to the acoustic startle response, Brain Res. 50: 457–462.

    Article  PubMed  CAS  Google Scholar 

  • Moyer, K. E., and Bunnell, B. N., 1960a, Effect of adrenal demedullation, operative stress, and noise stress on emotional elements, J. Genet. Psychol. 96: 375–382.

    Article  PubMed  CAS  Google Scholar 

  • Moyer, K. E., and Bunnell, B. N., 1960b, Relationship between emotional elimination, startle response, and blood count after stress, J. Genet. Psychol. 97: 237–243.

    Article  PubMed  CAS  Google Scholar 

  • Overstreet, D. H., 1977, Pharmacological approaches to habituation of the acoustic startle response in rats, Physiol. Psychol. 5: 230–238.

    Google Scholar 

  • Parisi, T., 1979, The ontogeny of modification of the acoustic startle reflex in normal rats and in rats treated systemically with 6-hydroxydopamine, unpublished Ph.D. thesis, University of Rochester.

    Google Scholar 

  • Parisi, T., and Ison, J. R., 1979, Development of the acoustic startle response in the rat: Ontogenic changes in the magnitude of inhibition by prepulse stimulation, Dev. Psychobiol. 12: 219–230.

    Article  PubMed  CAS  Google Scholar 

  • Payne, R., and Anderson, D. C., 1967, Scopolamine-produced changes in activity and in the startle response: Implications for behavioral activation, Psychopharmacology 12: 83–90.

    Article  CAS  Google Scholar 

  • Peterson, B. W., 1979, Reticulo-spinal projections to spinal motor nuclei, Annu. Rev. Physiol. 41: 127–140.

    Article  PubMed  CAS  Google Scholar 

  • Pohorecky, L. A., Cagan, M., Brick, J., and Jaffe, C.S., 1976, Startle response in rats: Effects of ethanol, Pharmacol. Biochem. Behay. 4: 311–316.

    Article  CAS  Google Scholar 

  • Prosser, C. L., and Hunter, W. S., 1936, The extinction of startle responses and spinal reflexes in the white rat, Am. J. Physiol. 17: 609–618.

    Google Scholar 

  • Ratner, S., 1970, Habituation: Research and theory, in: Current Issues in Animal Learning ( J. Reynierse, ed.), Lincoln, University of Nebraska Press, pp. 55–84.

    Google Scholar 

  • Rossignol, S., 1975, Startle responses recorded in the leg of man, Electroenceph. Clin. Neurophysiol. 39: 389–398.

    Article  PubMed  CAS  Google Scholar 

  • Rubel, E. W., 1978, Ontogency of structure and function in the vertebrate auditory system, Handbook of Sensory Physiol. IX: 135–234.

    Article  Google Scholar 

  • Russo, J. M., Reiter, L. A., and Ison, J. R., 1975, Repetitive exposure does not attenuate the sensory impact of the habituated stimulus, J. Comp. Physiol. Psychol. 88: 665–669.

    Article  Google Scholar 

  • Sagvolden, T., and Wester, K., 1974, Habituation of the startle reflex in rats with septal lesions, Behay. Biol. 12: 413.

    Article  CAS  Google Scholar 

  • Sharpe, L., Garnett, J. E., and Cicero, T. J., 1974, Analgesia and hyperreactivity produced by intracranial microinjections of morphine into the periaqueductal gray matter of the rat, Behay. Biol. 11: 303–313.

    Article  CAS  Google Scholar 

  • Shimamura, M., 1973, Neural mechanisms of the startle reflex in cerebral palsy, with special reference with spino-bulbo-spinal reflexes, in: New Development in Electromyography, Vol. 3 ( J. E. Desmedt, ed.), Karger, Basel, pp. 761–766.

    Google Scholar 

  • Shizgal, P., Brown, Z. W., Amit, Z., and Sklar, L., 1977, Differential motor effects of intraventricular infusions of morphine and etonitazene, Pharmacol. Biochem. Behay. 6: 17–20.

    Article  CAS  Google Scholar 

  • Shnerson, A., and Willott, J. F., 1980, Ontogeny of the acoustic startle response in C57B1/6J mouse pups, J. Comp. Physiol. Psychol. 94: 36–40.

    Article  PubMed  CAS  Google Scholar 

  • Singer, H. S., Coyle, J. T., Frangia, S., and Price, D. L., 1981, Effects of spinal transection on presynaptic markers for glutamanergic neurons in the rat, Neurochem. Res. 6: 485–496.

    Article  PubMed  CAS  Google Scholar 

  • Skirboll, L. R., Grace, A. A., and Bunney, B. S., 1979, Dopamine auto-and postsynaptic receptors: Electrophysiological evidence for differential sensitivity of dopamine ago-fists, Science 206: 80–83.

    Article  PubMed  CAS  Google Scholar 

  • Sorenson, C. A., and Davis, M., 1975, The effects of 6-hydroxydopamine and alpha-methylparatyrosine on the acoustic startle in rats, Pharmacol. Biochem. Behay. 3: 325–329.

    Article  CAS  Google Scholar 

  • Sorenson, C. A., and Swerdlow, N., 1982, The effect of tail pinch on the acoustic startle response in rats, Brain Res. 247: 105–113.

    Article  PubMed  CAS  Google Scholar 

  • Stern, W., 1971, Effects of desynchronized sleep deprivation upon startle response habituation in rats, Psychonomic Sci. 23: 31–32.

    Google Scholar 

  • Stitt, C. L., Hoffman, H. S., Marsh, R. R., and Schwartz, G. M., 1976, Modification of the pigeon’s visual startle reaction by the sensory environment, J. Comp. Physiol. Psychol. 90: 601–619.

    Article  PubMed  CAS  Google Scholar 

  • Strauss, H., 1929, “Oas Zusammenschrenken,” J. Psychol. U. Neurol. 39: 111–321.

    Google Scholar 

  • Szabo, I., 1965, Analysis of the muscular action potentials accompanying the acoustic startle reaction, Acta Physiol. Acad. Sci. Hung. 27: 167–178.

    Google Scholar 

  • Szabo, I., 1967, Positive correlation between the magnitude of the acoustic startle reaction and the performance of the active avoidance reaction, Acta Physiol. Acad. Sci. Hung. 31: 191–198.

    PubMed  CAS  Google Scholar 

  • Szabo, I., and Hazafi, K., 1965, Eliciability of the acoustic startle reaction after brain stem lesions, Acta Physiol. Acad. Sci. Hung. 27: 155–165.

    Google Scholar 

  • Thorne, F. C., 1944, Startle neurosis, Am. J. Psychiatr. 101: 105–109.

    Google Scholar 

  • Trapold, M. A., 1962, The effect of incentive motivation on an unrelated reflex response, J. Comp. Physiol. Psychol. 55: 1034–1039.

    Article  PubMed  CAS  Google Scholar 

  • VanderStaak, C., 1976, Habituation and sensitization of the acoustic startle response during cortical spreading depression in rats, Physiol. Behay. 16: 681–687.

    Article  CAS  Google Scholar 

  • Van Riezen, H., Schnieden, H., and Wren, A. F., 1977, Olfactory bulb ablation in the rat: Behavioral changes and their reversal by antidepressant drugs, Br. J. Pharmacol. 60: 521–528.

    Article  PubMed  Google Scholar 

  • Wagner, A. R., 1963, Conditioned frustration as a learned drive, J. Exp. Psychol. 66: 142–148.

    Article  PubMed  CAS  Google Scholar 

  • Wagner, A. R., 1976, Priming in STM: An information processing mechanism for self-generated or retrieval-generated depression in performance, in: Habituation: Perspectives from Child Development, Animal Behavior and Neurophysiology ( T. J. Tighe and R. N. Leaton, eds.), Lawrence Erlbaum Association, New Jersey, pp. 95–128.

    Google Scholar 

  • Wagner, A. R., Siegel, L. S., and Fein, G. S., 1967, Extinction of conditioned fear as a function of percentage of reinforcement, J. Comp. Physiol. Psychol. 63: 160–164.

    Article  PubMed  CAS  Google Scholar 

  • Walters, J. K., Davis, M., and Sheard, M. H., 1979, Tryptophan free diet: Effects on the acoustic startle reflex in rats, Psychopharmacology 62: 103–109.

    Article  PubMed  CAS  Google Scholar 

  • Warburton, D. M., and Groves, P. M., 1969, The effects of scopolamine on habituation of acoustic startle in rats, Commun. Behay. Biol. 3: 289–293.

    Google Scholar 

  • Warren, P. H., and Ison, J. R., 1982, The selective action of morphine on reflex expression to nociceptive stimulation in the rat: A contribution to the assessment of analgesia, Pharmacol. Biochem. Behay. 16: 869–874.

    Article  CAS  Google Scholar 

  • Way, E. H., Loh, H. H., and Shen, F. H., 1969, Simultaneous quantitative assessment of morphine tolerance and physical dependence, J. Pharmacol. Exp. Ther. 167: 1–8.

    PubMed  CAS  Google Scholar 

  • Wedeking, P., and Carlton, P. L., 1979, Habituation and sensitization in the modulation of reflex amplitude, Physiol. Behay. 22: 57–62.

    Article  CAS  Google Scholar 

  • White, S. R., and Neuman, R. S., 1980, Facilitation of spinal motoneurone excitability by 5-hydroxytryptamine and noradrenaline, Brain Res. 188: 119–128.

    Article  PubMed  CAS  Google Scholar 

  • Williams, J. M., Hamilton, L. W., and Carlton, P. L., 1974, Pharmacological and anatomical dissociation of two types of habituation, J. Comp. Physiol. Psychol. 87: 724–732.

    Article  PubMed  CAS  Google Scholar 

  • Williams, J. M., Hamilton, L. W., and Carlton, P. L., 1975, Ontogenetic dissociation of two classes of habituation, J. Comp. Physiol. Psychol. 89: 733–737.

    Article  PubMed  CAS  Google Scholar 

  • Willott, J. F., Shnerson, A., and Wilson, G. P., 1979, Sensitivity of the acoustic startle response and neurons in subnuclei of the mouse inferior colliculus to stimulus parameters, Exp. Neurol. 65: 625–644.

    Article  PubMed  CAS  Google Scholar 

  • Wilson, C. J., and Groves, P. M., 1973, Refractory period and habituation of acoustic startle response in rats, J. Comp. Physiol. Psychol. 83: 492–498.

    Article  PubMed  CAS  Google Scholar 

  • Wright, C. G., and Barnes, C. D., 1972, Audio-spinal reflex responses in decerebrate and chloralose anesthetized cats, Brain Res. 36: 307–331.

    Article  PubMed  CAS  Google Scholar 

  • Yunger, L. M., and Harvey, J. A., 1973, Effect of lesions in the medial forebrain bundle on three measures of pain, sensitivity, and noise-elicited startle, J. Comp. Physiol. Psychol. 83: 173–183.

    Article  PubMed  CAS  Google Scholar 

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  1. Department of Psychiatry, Connecticut Mental Health Center, Yale University, New Haven, Connecticut, 06508, USA

    Michael Davis

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  1. Behavioral Biology Group, Department of Biology, E.P.O., University of Colorado, 80309, Boulder, Colorado, USA

    Robert C. Eaton

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Davis, M. (1984). The Mammalian Startle Response. In: Eaton, R.C. (eds) Neural Mechanisms of Startle Behavior. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2286-1_10

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