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Polypeptides as Drugs

  • Chapter
Polymeric Materials in Medication

Part of the book series: Polymer Science and Technology ((POLS,volume 32))

Abstract

The non-random specific sequences of amino acids that comprise the endogenous peptides serve as a rich source of new pharmacophores from which drugs can be designed. Some of these natural peptides have been available as drugs. Many others can serve as focal points for drug development. In this review the types of peptide Pharmaceuticals will be enumerated. Indirect methods for control of endogenous peptider-gic processes will be discussed. The major problems in peptide pharmaceutical development will be outlined with many examples of peptide analogs that surmount these problems: peptides stabilized to proteolysis; peptides delivered by oral administration; peptides acting on the brain; and peptides with enhanced selective action. Peptides do not have to be reduced to small molecules to become drugs.

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Authors and Affiliations

  1. Peptide Chemistry Department, Smith Kline Beckman, Inc, 1050 Page Mill Road, Palo Alto, CA, 94304, USA

    James M. Samanen

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  1. James M. Samanen
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Editors and Affiliations

  1. Youngstown State University, Youngstown, Ohio, USA

    Charles G. Gebelein

  2. Florida Atlantic University, Boca Raton, Florida, USA

    Charles E. Carraher Jr.

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© 1985 Springer Science+Business Media New York

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Samanen, J.M. (1985). Polypeptides as Drugs. In: Gebelein, C.G., Carraher, C.E. (eds) Polymeric Materials in Medication. Polymer Science and Technology, vol 32. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2245-8_20

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  • DOI: https://doi.org/10.1007/978-1-4899-2245-8_20

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