Abstract
Osmium carbohydrate polymers, termed osmarins, exhibit a rich and varied oxygen chemistry. Biochemical assays demonstrate that osmarins react with Superoxide ions, and have activities which are comparable to those measured for peni-cillamine. In an assay which measures the capacity of compounds to protect porcine elastase inhibitor from deacti-vation by superoxide ions generated by stimulated neutro-phils, osmarins preserve up to 70% of the enzyme inhibitor capacity. A dependence upon osmarin composition was found in which the greatest activity was observed for osmarins of high (43%) osmium content. In a second assay, osmarins bound to rabbit cartilage were shown to protect the cartilage from degradation by neutrophils. Reactions of osmarins with di-oxygen in basic aqueous solutions were studied by following the visible absorption (480nm) of the solutions as a function of time. Osmarin solutions react with dioxygen with loss of color. The reactions are characterized by lengthy induction periods and can be treated as clock reactions. Clock times (induction periods) are dependent upon osmarin composition, the solution concentration, pH, oxygen pressure and the temperature. The reactions are overall first order in oxygen pressure and fractional order for both hydroxide and osmium concentration. Estimates of activation energies are 10–15 Kcal/mole (41–63 KJ/mole).
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Hinckley, C.C., Islam, M.A., Kibala, P.A., Skosey, J.L., Chow, D.C., Liu, S. (1985). Oxygen Species Chemistry of Osmium Carbohydrate Polymers. In: Gebelein, C.G., Carraher, C.E. (eds) Polymeric Materials in Medication. Polymer Science and Technology, vol 32. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2245-8_18
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DOI: https://doi.org/10.1007/978-1-4899-2245-8_18
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