Abstract
Iron chelation therapy is used to remove iron in cases of iron poisoning and Cooley’s Anemia. Cooley’s Anemia is characterized by an inability to synthesize the 3-chain of hemoglobin. Frequent transfusion, the primary treatment, introduces iron, which if not removed, accumulates to toxic levels. Deferioxamine-B(DFB), a naturally occurring tris-hydroxamic acid, is presently used to treat this condition. The structural positions of the three hydroxamic acids of DFB provides a powerful chelate effect and enhances iron binding. Modeled after DFB, vinyl polymers were constructed for potential use in iron chelation. The polymer and spacers position the hydroxamic acids in a way that provides good chelation effects. Bioassay in a mouse screen (Mason Research Institute) shows that many of the polymers are active in removing iron in vivo. We will discuss the effect of subtle changes in the structure of the polymer on the bioactivity and the tox-icity. Such changes include the nature of the spacer group and the presence or absence of a methyl group on a polymer chain or nitrogen.
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Winston, A., Varaprasad, D.V.P.R., Metterville, J.J., Rosenkrantz, H. (1985). Polymeric Hydroxamic Acids for Iron Chelators Therapy. In: Gebelein, C.G., Carraher, C.E. (eds) Polymeric Materials in Medication. Polymer Science and Technology, vol 32. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2245-8_17
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