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Polymeric Materials in Medication pp 151–163Cite as

Transformation of Mouse Fibroblast (T3T) Cells Employing the Oncogenic Simian Virus 40 (SV40) for Evaluation of Anticancer Compounds

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Part of the book series: Polymer Science and Technology ((POLS,volume 32))

Abstract

Infection of 3T3 cells by SV40 virus was studied. SV40 produced in permissive cells a carrier state that progressed to the transformed state. Carrageenan was shown to block the immune response partially. A measure of the relative inhibition of normal and transformed 3T3 cells could be a test of the effectiveness of potential anticancer drugs in selectively inhibiting cancer cells and thus offers a possible screening procedure for potential anticancer drugs.

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Author information

Authors and Affiliations

  1. Departments of Microbiology & Immunology, Wright State University, Dayton, Ohio, 45435, USA

    David J. Giron

  2. Departments of Microbiology and Chemistry, Wright State University, Dayton, Ohio, 45435, USA

    Mark J. Espy & Charles E. Carraher Jr.

  3. Florida Atlantic University, Boca Raton, FL, 33432, USA

    Charles E. Carraher Jr.

Authors
  1. David J. Giron
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  2. Mark J. Espy
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  3. Charles E. Carraher Jr.
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Editor information

Editors and Affiliations

  1. Youngstown State University, Youngstown, Ohio, USA

    Charles G. Gebelein

  2. Florida Atlantic University, Boca Raton, Florida, USA

    Charles E. Carraher Jr.

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© 1985 Springer Science+Business Media New York

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Giron, D.J., Espy, M.J., Carraher, C.E. (1985). Transformation of Mouse Fibroblast (T3T) Cells Employing the Oncogenic Simian Virus 40 (SV40) for Evaluation of Anticancer Compounds. In: Gebelein, C.G., Carraher, C.E. (eds) Polymeric Materials in Medication. Polymer Science and Technology, vol 32. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2245-8_13

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  • DOI: https://doi.org/10.1007/978-1-4899-2245-8_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-2247-2

  • Online ISBN: 978-1-4899-2245-8

  • eBook Packages: Springer Book Archive

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