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Molecular Biology of Aging pp 397–418Cite as

Amyloid, Immunopathology and Aging

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Part of the book series: Basic Life Sciences ((BLSC,volume 35))

Abstract

Recent advances in our understanding of the biochemistry and pathogenesis of the amyloid diseases have begun to provide information regarding the age-related amyloidoses in humans. Monospecific antisera to fibril subunit proteins are being used for the immunohistological typing of different forms of amyloid. This review will summarize current information relating amyloid to aging, particularly in regard to the pathoanatomic triad of islet cell hyalinization of the pancreas (type II diabetes mellitus), senile cardiac amyloidosis, and plaques/congophilic angiopathy in brain (senile dementia/Alzheimers disease).

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Authors and Affiliations

  1. Departments of Medicine, State University of New York, Stony Brook, New York, 11794, USA

    Peter D. Gorevic

  2. Departments of Pathology, State University of New York, Stony Brook, New York, 11794, USA

    Jules Elias & Nancy Peress

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  1. Peter D. Gorevic
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  2. Jules Elias
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Editors and Affiliations

  1. Brookhaven National Laboratory, Upton, New York, USA

    Avril D. Woodhead

  2. University of Manchester Institute of Science and Technology, Manchester, UK

    Anthony D. Blackett

  3. Council for Research Planning in Biological Sciences, Inc., Washington, DC, USA

    Alexander Hollaender

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Gorevic, P.D., Elias, J., Peress, N. (1985). Amyloid, Immunopathology and Aging. In: Woodhead, A.D., Blackett, A.D., Hollaender, A. (eds) Molecular Biology of Aging. Basic Life Sciences, vol 35. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2218-2_25

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