Abstract
A useful distinction has already been made between processes of aging and diseases of aging. The present session is devoted to several diseases of aging that may provide insights into broader mechanisms of aging processes. Three of the papers address the significance of disorders featuring apparently accelerated rates of aging—more particularly Hutchinson-Gilford progeria and Werner’s syndrome. The presentations of Dr. Brown and Dr. Salk will inquire into the extent that these rare conditions reflect authentic exaggeration of certain aging events as distinct from only mimicking them. Dr. Gracy will examine the molecular basis for protein errors in progeric fibroblasts and its relevance to aging in normal tissues. The mechanism he proposes—accumulation of deamidated forms through failure of proteolysis—should be juxtaposed to the conformational changes previously suggested by Dr. Rothstein.
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References
Sinex, E.M., Merril, C.R., (eds.) 1982, Alzheimer’s Disease, Down’s Syndrome, and Aging. Ann. N.Y. Acad. Sci. 396:1-199.
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© 1985 Springer Science+Business Media New York
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Sokoloff, L. (1985). Introductory Remarks, Session VI. In: Woodhead, A.D., Blackett, A.D., Hollaender, A. (eds) Molecular Biology of Aging. Basic Life Sciences, vol 35. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2218-2_23
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DOI: https://doi.org/10.1007/978-1-4899-2218-2_23
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