Abstract
Although the relative contributions of genetics and environment to aging in biological systems are not known, genes concerned and the possibilities for environmental modification of their expression are likely to be large in number. Inherited polymorphisms at the wide range of gene loci, or acquired mutations at these loci in somatic cell lineages, can have an influence on the aging process of the composite phenotype that constitutes a complex metazoan organism such as man.
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References
Chen, P., Lavin, M.F., Kidson, C., and Moss, D., 1978, Identification of ataxia telangiectasia heterozygotes, a cancer prone population, Nature, 274:484–486.
Chen, P., Kidson, C., and Imray, F.P., 1981, Huntington’s disease: implications of associated cellular radiosensitivity, Clin. Genet., 20:331–336.
Chen, P., Imray, F.P., and Kidson, C., 1984, Gene dosage and complementation analysis of ataxia-telangiectasia lymphoblastoid cell lines assayed by induced chromosome aberrations, Mutat. Res., 129:165–172.
Cox, R., Masson, W.K., Debenham, P.G. and Webb, M.B.T., 1984, The use of recombinant DNA plasmids for the determination of DNA-repair and recombination in cultured mammalian cells, Br. J. Cancer, Suppl. VI, 49:67–72.
Coyle, J.T., Price, D.L. and de Long, M.R., 1983, Alzheimer’s disease: a disorder of cortical cholinergic innervation, Science, 219:1184–1190.
Cutler, R.G., 1975, Evolution of human longevity and the genetic complexity governing aging rate, Proc. Natl. Acad. Sci. USA, 72:4664–4668.
Dambergs, R.G., and Kidson, C., 1977, Differential radiosensitivity of mouse embryonic neurons and glia in cell culture, J. Neuropath. Exp. Neurol., 36:576–585.
Dambergs, R.G., and Kidson, C., 1979, Quantitation of DNA repair in brain cell cultures: implications for autoradiographic analysis of mixed cell populations, Int. J. Radiat. Biol., 36:271–280.
Edwards, M.J., and Taylor, A.M.R., 1980, Unusual levels of ADP-ribose and DNA synthesis in ataxia-telangiectasia cells following γ-ray irraciation, Nature, 287:745–747.
Evans, H.J., and Vijayalaxmi, 1981, Induction of 8-azaguanine resistance and sister chromatid exchange in human lymphocytes exposed to mitomycin C and X-rays in vitro, Nature, 292:601–605.
Gensler, H.L., and Bernstein, H., 1981, DNA damage as the primary cause of aging, Quart. Rev. Biol., 56:279–303.
Gusella, J.F., Wexley, N., Conneally, P.M., Naylor, S.L., Anderson, M.A., Tannzi, R.E., Watkins, P.C., Ottina, K., Wallace, M.R., Sakaguchi, A.Y., Young, A.B., Shoulson, I., Bonilla, E., and Martin, J.B., 1983, A polymorphic DNA marker genetically linked to Huntington’s disease, Nature, 306: 234–238.
Hart, R.W., and Setlow, R.B., 1974, Correlation between deoxyribonucleic acid excision repair and lifespan in a number of mammalian species, Proc. Natl. Acad. Sci. USA, 71:2169–2173.
Houldsworth, J., and Lavin, M.F., 1980, Effect of ionizing radiation on DNA synthesis in ataxia-telangiectasia cells, Nucleic Acids Res., 8:3709–3720.
Ihora, Y., Abraham, C., and Selkoe, D.J., 1983, Antibodies to paired helical filaments in Alzheimer’s disease do not recognize normal brain proteins, Nature, 304:727–730.
Kato, M., Harada, M., Tsuchiya, K., and Moriawaki, K., 1980, Absence of correlation between DNA repair in ultraviolet irradiated mammalian cells and life span of the donor species, Jpn. J. Genet., 55:99–104.
Kidson, C., 1978, DNA repair in differentiation, in: “DNA Repair Mechanisms”, pp. 761–768, P.C. Hanawalt, E.C. Friedberg and C.F. Fox, eds., Academic Press, New York.
Kidson, C., 1979, Repair systems and differentationn in: “Radiation Research”, pp. 627–631, S. Okada, M. Immamura, T. Terashima and H. Yamaguchi, eds., Toppan, Tokyo.
Kidson, C., 1980, Diseases of DNA repair, Clin. Haematol., 9:141–157.
Kidson, C., and Dambergs, R., 1982, Nervous system development and ataxia-telangiectasia, in: “A Cellular and Molecular link between Cancer, Neuropathology and Immune Deficiency”, pp. 373–377, B.A. Bridges and D.G. Harnden, eds., John Wiley and Sons, Chichester.
Kidson, C., Chen, P., Imray, F.P., and Gipps, E., 1983, Nervous system disease associated with dominant cellular radiosensitivity, in: “Cellular Responses to DNA Damage”, pp. 721–729, E.C. Fiedberg and B.A. Bridges, eds., Alan R. Liss, New York.
Lett, J.T., Keng, P.C., and Sun, C., 1978, Rejoining of DNA strand breaks in nondividing cells irradiated in situ, in: “DNA Repair Mechanisms”, pp. 481–484, P.C. Hanawalt, E.C. Friedberg and C.F. Fox, eds., Academic Press, New York.
Little, J.W. and Mount, D.W., 1982, The SOS regulatory system of Escherichia coli, Cell. 29:11–22.
Medawar, P.B., 1952, “An Unsolved Problem in Biology”, H.K. Lewis, London.
Ono, T., Okada, S. and Sugahara, T., 1976, Comparative studies of DNA size in various tissues of mice during the aging process, Exp. Gerontol., 11:127–132.
Orgel, L.E., 1963, The maintenance of the accuracy of protein synthesis and its relevance to aging, Proc. Natl. Acad. Sci. USA, 49:517–521.
Paterson, M.C., Smith, P.J., Bech-Hansen, N.T., Smith, B.P., and Middlestadt, M.V., 1982, Anomalous repair in radiogenic DNA damage in skin fibrobalsts from ataxia-telangiectasia patients, in: “Ataxia-telangiectasia-A Cellular and Molecular Link between Cancer, Neuropathology and Immune Deficiency,” pp. 271–289, B. A. Bridges and D. G. Harriden, eds., John Wiley and Sons, Chichester.
Price, G.B., Modak, S.P., and Makinodan, T., 1971, Age-associated changes in the DNA of mouse tissue, Science, 171:917–920.
Prusiner, S.B., 1984, Some speculations about prions, amyloid and Alzheimer’s disease, New Engl. J. Med., 310:661–663.
Purves, D., 1980, Neuronal competition. Nature, 287:585–586.
Robbins, J.H., 1983, Hypersensitivity to DNA-damaging agents in primary degenerations of excitable tissue, in: “Cellular Responses to DNA damage”, pp. 671–700, E.C. Friedberg and B.A. Bridges, eds., Alan R. Liss, New York.
Sedgwick, R.P., 1982, Neurological abnormalities in ataxia-telangiectasia, in: “Ataxia-telangiectasia-A Cellular and Molecular Link between Cancer, Neuropathology and Immune Deficiency”, pp. 23–25, B.A. Bridges and D.G. Harnden, eds., John Wiley and Sons, Chichester.
Waldman, T.A., 1982, Immunological abnormalities in ataxia-telangiectasia, in: “Ataxia-telangiectasia-A Cellular and Molecular Link between Cancer, Neuropathology and Immune Deficiency”, pp. 37–51, B.A. Bridges and D.G. Harnden, eds., John Wiley and Sons, Chichester.
Williams, G.C., 1957, Pleiotropy, natural selection and the evolution of senescence, Evolution, 11:398.
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Kidson, C., Chen, P., Imray, F.P. (1985). DNA Manipulating Genes and the Aging Brain. In: Woodhead, A.D., Blackett, A.D., Hollaender, A. (eds) Molecular Biology of Aging. Basic Life Sciences, vol 35. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2218-2_18
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DOI: https://doi.org/10.1007/978-1-4899-2218-2_18
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