Abstract
In this paper we review our recent studies on the human fibroblast model of cellular aging, which illustrate how physiological decline and certain age-dependent diseases may develop at the cellular level. We will demonstrate that the basis of these changes may involve a variety of alterations in genetic structure and expression, and further, that their stochastic nature probably accounts for the progressive individual variation that occurs between aging persons and between their component cells.
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Goldstein, S., Srivastava, A., Riabowol, K.T., Reis, R.J.S. (1985). Changes in Genetic Organization and Expression in Aging Cells. In: Woodhead, A.D., Blackett, A.D., Hollaender, A. (eds) Molecular Biology of Aging. Basic Life Sciences, vol 35. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2218-2_16
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DOI: https://doi.org/10.1007/978-1-4899-2218-2_16
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