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Genetic Studies of Nicotinic and Muscarinic Agents

  • Chapter
The Genetic Basis of Alcohol and Drug Actions

Abstract

Recent advances in the understanding of human behaviors indicate that genetic factors often play a critical role in regulating variation in behavior. Special attention has been paid to abnormal behaviors ranging from psychopathology to drug, usually alcohol, dependence. This chapter summarizes the data that suggest that genetic factors regulate the nicotinic and muscarinic cholinergic systems. Studies that indicate that the use of tobacco products by humans is genetically regulated are discussed in detail, as are animal studies that indicate that genetically determined differences in several aspects of nicotine pharmacology exist. Special emphasis is placed on those animal studies that have identified biochemical processes that may play critical roles in regulating genetically influenced variation in nicotine’s actions. A more cursory discussion of the genetics of human affective disorders is followed by an equally cursory summation of the limited animal literature, which argues that genetically determined variation in muscarinic cholinergic systems exists.

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Authors and Affiliations

  1. Department of Psychology and Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado, 80309, USA

    Allan C. Collins & Michael J. Marks

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  1. Allan C. Collins
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  2. Michael J. Marks
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Editors and Affiliations

  1. Research Service, Department of Veterans Affairs Medical Center and Departments of Medical Psychology and Pharmacology, Oregon Health Sciences University, Portland, Oregon, 97201, USA

    John C. Crabbe Jr.

  2. Research Service, Veterans Administration Medical Center and Department of Pharmacology, University of Colorado Health Sciences Center, Denver, Colorado, 80262, USA

    R. Adron Harris

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© 1991 Springer Science+Business Media New York

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Collins, A.C., Marks, M.J. (1991). Genetic Studies of Nicotinic and Muscarinic Agents. In: Crabbe, J.C., Harris, R.A. (eds) The Genetic Basis of Alcohol and Drug Actions. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2067-6_9

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  • DOI: https://doi.org/10.1007/978-1-4899-2067-6_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-2069-0

  • Online ISBN: 978-1-4899-2067-6

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