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The Genetic Basis of Alcohol and Drug Actions pp 279–321Cite as

Genetic Differences in Response to Cocaine and Stimulant Drugs

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Abstract

The term psychomotor stimulant generally refers to pharmacologically active compounds recognized by their prominent ability to enhance motor activity through their activation of the central nervous system. This class of agents includes cocaine, amphetamine, and caffeine. These and other compounds included in this pharmacological class differ from one another in their chemical structures and in their mechanisms of direct action on brain cells (Ritz et al., 1987; Miller et al., 1989; Snyder, 1985; Frantz, 1985; Johanson and Fischman, 1989; Pitts and Marwah, 1988). These compounds share the common property of selectively activating neural firing rates in specific regions of the brain (Wechsler et al., 1979; London et al., 1986; Porrino and Kornetsky, 1988; Nehlig et al., 1988), and they induce similar but nonidentical behavioral changes (Balster, 1988; Snyder, 1985; Gold et al., 1989).

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  1. Departments of Pediatrics, Psychiatry, and Biochemistry, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, 73190, USA

    Thomas W. Seale

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  1. Research Service, Department of Veterans Affairs Medical Center and Departments of Medical Psychology and Pharmacology, Oregon Health Sciences University, Portland, Oregon, 97201, USA

    John C. Crabbe Jr.

  2. Research Service, Veterans Administration Medical Center and Department of Pharmacology, University of Colorado Health Sciences Center, Denver, Colorado, 80262, USA

    R. Adron Harris

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Seale, T.W. (1991). Genetic Differences in Response to Cocaine and Stimulant Drugs. In: Crabbe, J.C., Harris, R.A. (eds) The Genetic Basis of Alcohol and Drug Actions. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2067-6_8

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