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Studies of Genetic Differences in Response to Opioid Drugs

  • Chapter
The Genetic Basis of Alcohol and Drug Actions

Abstract

Over the past few years, a rather impressive amount of research with opioids has been conducted using various inbred strains, most commonly the BALB/c, C57BL/6, C3H/He, and the DBA/2 mouse strains. Much of this work has been reviewed by Oliverio and Castellano (1981), Horowitz (1981), Horowitz and Dudek (1983), Shuster (1984a, b, 1986, 1989), Crabbe et al. (1985), and Frishknecht et al. (1988). These reviews should be consulted for a more complete picture of this area of research. Research with recombinant inbred strains is reviewed separately.

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  1. Research Service, Department of Veterans Affairs Medical Center and Department of Medical Psychology, Oregon Health Sciences University, Portland, Oregon, 97201, USA

    J. K. Belknap & L. A. O’Toole

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  1. J. K. Belknap
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  2. L. A. O’Toole
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  1. Research Service, Department of Veterans Affairs Medical Center and Departments of Medical Psychology and Pharmacology, Oregon Health Sciences University, Portland, Oregon, 97201, USA

    John C. Crabbe Jr.

  2. Research Service, Veterans Administration Medical Center and Department of Pharmacology, University of Colorado Health Sciences Center, Denver, Colorado, 80262, USA

    R. Adron Harris

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Belknap, J.K., O’Toole, L.A. (1991). Studies of Genetic Differences in Response to Opioid Drugs. In: Crabbe, J.C., Harris, R.A. (eds) The Genetic Basis of Alcohol and Drug Actions. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2067-6_6

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