Abstract
Traumatic injury is a complex physiological stimulus that evokes a diverse array of autonomic and endocrine responses (1). Although a complete understanding of the compensatory responses to traumatic injury is not yet possible, a useful experimental approach has been to consider these responses as expressions of the efferent limb of a broad neuroendocrine reflex. The reflex derives its sensory input from multiple sources, requires integration by central neural pathways and is expressed as the autonomic or endocrine adjustments to the applied stimulus. An overview of this reflex is seen in Fig. 1. Several sources of afferent input that likely accompany traumatic injury are indicated as are several brain regions thought to be of major importance in neural integration and modulation of the afferent sensory input. The animal preparations used to explore the components of this reflex often require the use of anesthesia; however, valuable information may be obtained that is relevant for understanding the responses to traumatic injury as well as for understanding the compensatory responses to surgical stress in man.
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Bereiter, D.A., DeMaria, E.J., Engeland, W.C., Gann, D.S. (1988). Endocrine Responses to Multiple Sensory Input Related to Injury. In: Chrousos, G.P., Loriaux, D.L., Gold, P.W. (eds) Mechanisms of Physical and Emotional Stress. Advances in Experimental Medicine and Biology, vol 245. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2064-5_20
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DOI: https://doi.org/10.1007/978-1-4899-2064-5_20
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