Abstract
One of the questions raised repeatedly at this meeting was whether biochemical markers such as DNA and protein adducts of chemical carcinogens were or could be biomarkers of effect, which is to say that the concentration of the marker is proportional in some way to the probability of developing cancer. The question was left unresolved, principally for lack of data which could be used to attempt an answer. In several studies of 4-aminobiphenyl-hemoglobin adducts and bladder cancer in Prof. S. R. Tannenbaum’s laboratory at MIT, we have now made measurements of this biomarker in more than 500 subjects collectively. It is the purpose of this paper to compile these data and analyze them with a view to determining the predictive power of this biomarker.
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© 1993 Springer Science+Business Media New York
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Skipper, P.L. (1993). The 4-Aminobiphenyl Hemoglobin Adduct as a Biomarker of Effect. In: Travis, C.C. (eds) Use of Biomarkers in Assessing Health and Environmental Impacts of Chemical Pollutants. NATO ASI Series, vol 250. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2052-2_2
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DOI: https://doi.org/10.1007/978-1-4899-2052-2_2
Publisher Name: Springer, Boston, MA
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