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Somites in Developing Embryos pp 247–259Cite as

Initiation of Chondrogenesis from Somitic, Limb and Craniofacial Mesenchyme: Search for a Common Mechanism

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Part of the book series: NATO ASI Series ((NSSA,volume 118))

Abstract

The mechanism whereby the notochord and ventral portion of the spinal cord influence chondrogenesis of sclerotomal mesenchyme has been the subject of considerable study, including an extensive review of work performed during 1925–1977 (Hall, 1977) and a review by Vasan in this volume.

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References

  • Avery, G., Chow, M., and Holtzer, H., 1956, An experimental analysis of the development of the spinal column. V. Reactivity of chick somites. J. Exp. Zool, 132: 409.

    Article  Google Scholar 

  • Belsky, E., Vasan, N.S., and Lash, J.W., 1980, Extracellular matrix components and somite chondrogenesis: a microscopic analysis. Devel. Biol, 79: 159.

    Article  CAS  Google Scholar 

  • Benoit, J.A.A., 1960, Induction de cartilage in vitro par l’extrait d’otocystes d’embryons de Poulet. J. Embryol. exp. Morph, 8: 33.

    CAS  PubMed  Google Scholar 

  • Caplan, A.I., 1985, The vasculture and limb development. Cell Differentiation, 16: 1.

    Article  CAS  PubMed  Google Scholar 

  • Carlson, B.M., 1984, The preservation of the ability of cultured quail wing bud mesoderm to elicit a position-related differentiative response. Devel. Biol, 101: 106.

    Article  CAS  Google Scholar 

  • Carlson, E.C., and Kenney, M.C., 1980, Surface ultrastructure of the isolated avian notochord in vitro: the effect of the perinotochordal sheath. Anat. Rec, 197: 257.

    Article  CAS  PubMed  Google Scholar 

  • Cheney, C.M., and Lash, J.W., 1981, Diversification within embryonic chick somites: differential response to notochord. Devel. Biol, 81: 288.

    Article  CAS  Google Scholar 

  • Cooper, G.W., 1965, Induction of somite chondrogenesis by cartilage and notochord: a correlation between inductive activity and specific stages of cytodifferentiation. Devel. Biol, 12: 185.

    Article  CAS  Google Scholar 

  • Desbiens, X., 1983, Étude expérimentale de l’effet de l’ectoderme sur la chondrification du mésoderme de membre embryonnaire de Souris in vitro. Résultats d’une analyse histologique. C.R. Acad. Sci. Paris, 296: 593.

    CAS  Google Scholar 

  • Feinberg, R.N., and Beebe, D.C., 1983, Hyaluronate in vasculogenesis. Science, 220: 1177.

    Article  CAS  PubMed  Google Scholar 

  • Fernandez-Teran, M.A., and Hurle, J.M., 1984, Syndactyly induced by Janus Green B in the embryonic chick leg bud: a reexamination. J. Embryol. exp. Morph, 84: 159.

    CAS  PubMed  Google Scholar 

  • Gay, S.W., and MacCabe, J.A., 1984, Pattern regulation along the proximodistal axis of the developing chick limb. J. Exp. Zool, 229: 447.

    Article  CAS  PubMed  Google Scholar 

  • Grobstein, C., and Holtzer, H., 1955, In vitro studies of cartilage induction in mouse somite mesoderm. J. Exp. Zool, 128: 333.

    Article  Google Scholar 

  • Gumpel-Pinot, M., 1972, Culture in vitro de l’ébauche de l’aile de l’embryon de Poulet. Rôle de l’ectoderme sur la chondrogenèse. C.R. Acad. Sci. Paris, 274: 2786.

    CAS  Google Scholar 

  • Gumpel-Pinot, M., 1973, Culture in vitro de bourgeon d’aile de l’embryon de Poulet: différenciation du cartilage. Ann. Biol, 12: 417.

    Google Scholar 

  • Gumpel-Pinot, M., 1980, Ectoderm and mesoderm interactions in the limb bud of the chick embryo studied by transfilter cultures: cartilage differentiation and ultrastructural observations. J. Embryol. exp. Morph, 59: 157.

    CAS  PubMed  Google Scholar 

  • Gumpel-Pinot, M., 1981, Ectoderm-mesoderm interactions in relation to limb bud chondrogenesis in the chick embryo: transfilter cultures and ultrastructural studies. J. Embryol. exp. Morph, 65: 73.

    CAS  PubMed  Google Scholar 

  • Gumpel-Pinot, M., 1982, Cartilage differentiation in the limb bud of the chick embryo. Ultrastructural observations, culture and grafting experiments. Arch. d’Anat. Microsc, 71: 241.

    CAS  Google Scholar 

  • Hall, B.K., 1977, Chondrogenesis of the somitic mesoderm. Adv. Anat. Embryol. & Cell Biol, 53(4): 1.

    Google Scholar 

  • Hall, B.K., 1978, “Developmental and Cellular Skeletal Biology,” Academic Press, New York.

    Google Scholar 

  • Hall, B.K., 1983, Epithelial-mesenchymal interactions in cartilage and bone development. in: “Epithelial-Mesenchymal Interactions in Development” (eds R.H. Sawyer and J.F. Fallon), Praeger Press, New York., pp189–214.

    Google Scholar 

  • Hall, B.K., 1984, Matrices control the differentiation of cartilage and bone. in: “Matrices and Cell Differentiation” (eds R.J. Kemp and J.R. Hinchliffe), Alan R. Liss Inc, New York., pp 147–169.

    Google Scholar 

  • Hattori, T., and Ide, H., 1984, Limb bud chondrogenesis in cell culture, with particular reference to serum concentration in the culture medium. Exp. Cell Res, 150: 338.

    Article  CAS  PubMed  Google Scholar 

  • Hay, E.D., and Meier, S., 1974, Glycosaminoglycan synthesis by embryonic inductors-neural tube, notochord and lens. J. Cell Biol, 62: 889.

    Article  CAS  PubMed  Google Scholar 

  • Holtfreter, J., 1968, Mesenchyme and epithelia in inductive and morphogenetic processes. in: “Epithelial-Mesenchymal Interactions” (eds R. Fleischmajer and R.E. Billingham), Williams & Wilkins, Baltimore., pp 1–30.

    Google Scholar 

  • Holtzer, H., 1964, Control of chondrogenesis in the embryo. Biophys. J., 4: 239.

    Article  CAS  PubMed  Google Scholar 

  • Johnston, P.M., and Comar, C.L., 1957, Autoradiographic studies of the utilization of S35-sulfate by the chick embryo. J. Biophys. Biochem. Cytol, 3: 231.

    Article  CAS  PubMed  Google Scholar 

  • Kenney, M.C., and Carlson, E., 1978, Ultrastructural identification of collagen and glycosaminoglycans in notochordal extracellular matrix in vivo and in vitro. Anat. Rec, 190: 827.

    Article  CAS  PubMed  Google Scholar 

  • Kimura, T., Yasui, N., Ohsawa, S., and Ono, K., 1984, Chondrogenic differentiation of limb bud cells in collagen gel culture. Biomed. Res, 5: 465.

    CAS  Google Scholar 

  • Kosher, R.A., 1976, Inhibition of “spontaneous”, notochord-induced and collagen-induced in vitro somite chondrogenesis by cyclic AMP derivatives and theophylline. Devel. Biol, 53: 265.

    Article  CAS  Google Scholar 

  • Kosher, R.A., and Church, R.L., 1975, Stimulation of in vitro somite chondrogenesis by procollagen and collagen. Nature, 258: 327.

    Article  CAS  PubMed  Google Scholar 

  • Kosher, R.A., and Lash, J.W., 1975, Notochordal stimulation of in vitro somite chondrogenesis before and after enzymatic removal of peri-notochordal materials. Devel. Biol, 43: 362.

    Article  Google Scholar 

  • Kosher, R.A., and Savage, M.P., 1979, The Effect of collagen on the cyclic AMP content of embryonic somites. J. Exp. Zool, 208: 35.

    Article  CAS  PubMed  Google Scholar 

  • Kosher, R.A., and Savage, M.P., 1981, Glycosaminoglycan synthesis by the apical ectodermal ridge of chick wing bud. Nature, 291: 231.

    Article  CAS  PubMed  Google Scholar 

  • Kosher, R.A., Lash, J.W., and Minor, R.R., 1973, Environmental enhancement of in vitro chondrogenesis. IV. Stimulation of somite chondrogenesis by exogenous chondromucoprotein. Devel. Biol, 35: 210.

    Article  CAS  Google Scholar 

  • Kosher, R.A., Savage, M.P., and Chan, S.-C., 1979a, In vitro studies on the morphogenesis and differentiation of the mesoderm subjacent to the apical ectodermal ridge of the embryonic chick limb bud. J. Embryol. exp. Morph, 50: 75.

    CAS  PubMed  Google Scholar 

  • Kosher, R.A., Savage, M.P., and Chan, S.-C., 1979b, Cyclic AMP derivatives stimulate the chondrogenic differentiation of the mesoderm subjacent to the apical ectodermal ridge of the chick limb bud. J. Exp. Zool, 209: 221.

    Article  CAS  PubMed  Google Scholar 

  • Kosher, R.A., Savage, M.P., and Walker, K.H., 1981, A gradation of hyaluronate accumulation along the proximodistal axis of the embryonic chick limb bud. J. Embryol. exp. Morph, 63: 85.

    CAS  PubMed  Google Scholar 

  • Kratochwil, K., 1983, Embryonic induction. in: “Cell Interactions and Development. Molecular Mechanisms” (ed K.M. Yamada), Wiley Interscience, New York., pp. 99.

    Google Scholar 

  • Kvist, T.N., and Finnegan, C.V., 1970, The distribution of glycosaminoglycans in the axial region of the developing chick embryo. II. Biochemical analysis. J. Exp. Zool, 175: 241.

    Article  CAS  PubMed  Google Scholar 

  • Lash, J.W., 1964, Normal embryology and teratogenesis. Amer. J. Obstet. Gynecol, 90: 1193.

    Google Scholar 

  • Lash, J.W., 1968, Phenotypic expression and differentiation: in vitro chondrogenesis. in: “The Stability of the Differentiated State”, (ed. H. Ursprung), Springer-Verlag, Berlin., pp. 17–24.

    Google Scholar 

  • Lash, J.W., and Cheney, C.M., 1982, Diversification within embryonic chick somites: in vitro analysis of proteoglycan synthesis. in: “Differentiation in vitro,” (eds M.M. Yeoman and D.E.S. Truman). Cambridge University Press, Cambridge, pp. 193–206.

    Google Scholar 

  • Lash, J.W., and Vasan, N.S., 1978, Somite chondrogenesis in vitro: stimulation by exogenous extracellular matrix components. Devel. Biol, 66: 151.

    Article  CAS  Google Scholar 

  • Lauscher, C.K., and Carlson, E.C., 1975, The development of proline-containing extracellular connective tissue fibrils by chick notochordal epithelium in vitro. Anat. Rec, 182: 151.

    Article  CAS  PubMed  Google Scholar 

  • Maden, M., 1984, Does vitamin A act on pattern formation via the epidermis or the mesoderm?. J. Exp. Zool, 230: 387.

    Article  CAS  Google Scholar 

  • Milaire, J., 1974, “Histochemical aspects of organogenesis in Vertebrates,” Handbuch d. Histochemie VIII, suppl. 3.

    Google Scholar 

  • Milaire, J., and Mulnard, J., 1968, Le role de l’epiblaste dans la chondrogenese du bourgeon de membre chez la souris. J. Embryol. exp. Morph, 20: 215.

    CAS  PubMed  Google Scholar 

  • Newsome, D.A., 1972, Cartilage induction by retinal pigmented epithelium of chick embryo. Devel. Biol, 27: 575.

    Article  CAS  Google Scholar 

  • Newsome, D.A., 1976, In vitro stimulation of cartilage in embryonic chick neural crest cells by products of retinal pigmented epithelium. Devel. Biol, 49: 496.

    Article  CAS  Google Scholar 

  • Nieuwkoop, P.D., Johnen, A.G., and Albers, F., 1985, “The Epigenetic Nature of Early Chordate Development,” Cambridge University Press, Cambridge.

    Google Scholar 

  • Noden, D.M., 1984, The use of chimeras in analysis of craniofacial development. in: “Chimeras in Developmental Biology,” (ed. N.M. Le Douarin and A. McLaren), Academic Press, London., pp. 241–280.

    Google Scholar 

  • Oettinger, H.F., Thal, G., Sasse, J., Holtzer, H., and Pacifico, M., 1985, Immunological analysis of chick notochordal and cartilage matrix development with antisera to cartilage matrix macromolecules. Devel. Biol, 109: 63.

    Article  CAS  Google Scholar 

  • O’Hare, M.J., 1972, Chondrogenesis in chick embryo somites grafted with adjacent and heterologous tissues. J. Embryol. exp. Morph, 27: 229.

    PubMed  Google Scholar 

  • Owens, E.M., and Solursh, M., 1981, In vitro histogenic capacities of limb mesenchyme from various stage mouse embryos. Devel. Biol, 88: 297.

    Article  CAS  Google Scholar 

  • Owens, E.M., and Solursh, M., 1982, Cell-cell interaction by mouse limb cells during in vitro chondrogenesis: analysis of the brachypod mutation. Devel. Biol, 91: 376.

    Article  CAS  Google Scholar 

  • Owens, E.M., and Solursh, M., 1983, Accelerated maturation of limb mesenchyme by the brachypod H mouse mutation. Differentiation, 24: 145.

    Article  CAS  PubMed  Google Scholar 

  • Paulsen, D.F., Finch, R.A., and Parker, C.L., 1980, Age-and region-dependent redistribution of con A binding sites on chick wing bud mesoderm cells. J. Exp. Zool, 213: 369.

    Article  Google Scholar 

  • Reinbold, R., 1968, Rôle du tapetum dans la différenciation de la sclérotique chez l’embryon de poulet. J. Embryol. exp. Morph, 19: 43.

    CAS  PubMed  Google Scholar 

  • Saunders, J.W. Jr., 1948, The proximo-distal sequence of origin of the parts of the chick wing and the role of the ectoderm. J. Exp. Zool, 108: 363.

    Article  PubMed  Google Scholar 

  • Searls, R.L., 1968, Development of the embryonic chick limb bud in avascular culture. Devel. Biol, 17: 382.

    Article  CAS  Google Scholar 

  • Searls, R.L., 1983, Evidence for inherent morphogenetic properties of the myogenic regions of the embryonic chick wing. J. Exp. Zool, 226: 59.

    Article  CAS  PubMed  Google Scholar 

  • Seno, T., and Büyüközer, I., 1958, Cartilage formation in somite grafts of chick blastoderm. Proc. Nat. Acad. Sci. USA, 44: 1274.

    Article  CAS  PubMed  Google Scholar 

  • Shur, B.D., Vogler, M., and Kosher, R.A., 1982, Changes in endogenous cell surface galactosyltransferase activity during in vitro limb bud chondrogenesis. Exp. Cell Res, 137: 229.

    Article  CAS  PubMed  Google Scholar 

  • Singley, C.T., and Solursh, M., 1981, The spatial distribution of hyaluronic acid and mesenchymal condensation in the embryonic chick wing. Devel. Biol, 84: 102.

    Article  CAS  Google Scholar 

  • Smith, L., and Thorogood, P.V., 1983, Transfilter studies on the mechanism of epithelio-mesenchymal interaction leading to chondrogenic differentiation of neural crest cells. J. Embryol. exp. Morph, 75: 165.

    CAS  PubMed  Google Scholar 

  • Smith, J.C., and Watt, F.M., 1985, Biochemical specificity of Xenopus notochord. Differentiation, 29: 109.

    Article  CAS  PubMed  Google Scholar 

  • Solursh, M., 1984, Cell and matrix interactions during limb chondrogenesis in vitro, in: “The Role of Extracellular Matrix in Development,” (ed R.L. Threlstad), Alan R. Liss, Inc, New York., pp. 277.

    Google Scholar 

  • Solursh, M., and Reiter, R.S., 1980, Evidence for histogenic interactions during in vitro limb chondrogenesis. Devel. Biol, 78: 141.

    Article  CAS  Google Scholar 

  • Solursh, M., Singley, C.T., and Reiter, R.S., 1981, The influence of epithelia on cartilage and loose connective tissue formation by limb mesenchyme cultures. Devel. Biol, 86: 471.

    Article  CAS  Google Scholar 

  • Solursh, M., Jensen, K.L., Singley, C.T., Linsenmayer, T.F., and Reiter, R.S., 1982, Two distinct regulatory steps in cartilage differentiation. Devel. Biol, 94: 311.

    Article  CAS  Google Scholar 

  • Solursh, M., Jensen, K.L., Zanetti, N.C., Linsenmayer, T.F., and Reiter, R.S., 1984, Extracellular matrix mediates epithelial effects on chondrogenesis in vitro. Devel. Biol, 105: 451.

    Article  CAS  Google Scholar 

  • Stark, R.J., and Searls, R.L., 1974, The establishment of the cartilage pattern in the embryonic chick wing, and evidence for a role of the dorsal and ventral ectoderm in normal wing development. Devel. Biol, 38: 51.

    Article  CAS  Google Scholar 

  • Stewart, P.A., and McCallion, D.J., 1975, Establishment of the scleral cartilage in the chick. Devel. Biol, 46: 383.

    Article  CAS  Google Scholar 

  • Strudel, G., 1963, Autodifférenciation et induction de cartilage à partir de mésenchyme somitique de Poulet cultivé in vitro. J. Embryol. exp. Morph, 11: 399.

    CAS  PubMed  Google Scholar 

  • Summerbell, D., 1974, A quantitative analysis of the effect of excision of the AER from the chick wing bud. J. Embryol. exp. Morph, 32: 651.

    CAS  PubMed  Google Scholar 

  • Swalla, B.J., and Solursh, M., 1984, Epithelial enhancement of connective tissue differentiation in explanted somites. J. Embryol. exp. Morph, 79: 243.

    CAS  PubMed  Google Scholar 

  • Swalla, B.J., Owens, E.M., Linsenmayer, T.F., and Solursh, M., 1983, Two distinct classes of prechondrogenic cell types in the embryonic limb bud. Devel. Biol, 97: 59.

    Article  CAS  Google Scholar 

  • Tetsuro, K., 1982, Microfibril formation in chick notochordal cells. Tissue and Cell, 14: 171.

    Article  Google Scholar 

  • Theiler, K., 1972, “The House Mouse. Development and Normal Stages from Fertilization to 4 Weeks of Age,” Springer-Verlag, Berlin.

    Google Scholar 

  • Thorogood, P.V., and Smith, L., 1984, Neural crest cells: the role of extracellular matrix in their differentiation and migration. in: “Matrices and Cell k ifferentiation,” (eds R.J. Kemp and J.R. Hinchliffe), Alan R. Liss Inc, New York, pp. 171.

    Google Scholar 

  • Thorogood, P.V., Bee, J., and von der Mark, K., 1986, Transient expression of collagen type II at epithelio-mesenchymal interfaces during morphogenesis of the cartilageinous neurocranium. Devel. Biol, (in press).

    Google Scholar 

  • Vasan, N.S., 1981, Analysis of perinotochordal materials. 1. Studies on proteoglycan synthesis. J. Exp. Zool, 215: 229.

    Article  CAS  PubMed  Google Scholar 

  • Vasan, N.S., 1983, Analysis of perinotochordal materials. 2. Studies on the influence of proteoglycans in somite chondrogenesis. J. Embryol. exp. Morph, 73: 263.

    CAS  PubMed  Google Scholar 

  • Vasan, N.S., and Miller, E., 1985, Somite chondrogenesis in vitro: differential induction by modified matrix-a biochemical and morphological study. Dev. Growth & Differ, 27: 405.

    Article  CAS  Google Scholar 

  • Vasan, N.S., Lamb, K.M., and Heick, A.E., 1985 Somite chondrogenesis: alterations in cyclic AMP levels and proteoglycan synthesis. Cell Differ, 16, 229.

    Article  CAS  PubMed  Google Scholar 

  • Vasan, N.S., Lamb, K.M., and Manna, O. La., 1986a, Somite chondrogenesis in vitro: 1. alterations in proteoglycan synthesis. Cell Differ, 18: 79.

    Article  CAS  PubMed  Google Scholar 

  • Vasan, N.S., Lamb, K.M., and Manna, O. La., 1986b, Somite chondrogenesis in vitro: 2. changes in the hyaluronic acid synthesis. Cell Differ, 18: 91.

    Article  CAS  PubMed  Google Scholar 

  • Zanetti, N.C., and Solursh, M., 1984, Induction of chondrogenesis in limb mesenchymal cultures by disruption of the actin cytoskeleton. J. Cell Biol, 99: 115.

    Article  CAS  PubMed  Google Scholar 

  • Zanetti, N.C., and Solursh, M., 1986, Epithelial effects on limb chondrogenesis involve extracellular matrix and cell shape. Devel. Biol, 113: 110.

    Article  CAS  Google Scholar 

  • Zwilling, E., 1949, The role of epithelial components in the developmental origins of the ‘wingless’ syndrome of chick embryos. J. Exp. Zool, 111: 175.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Biology, Dalhousie University, Halifax, N.S., Canada, B3H 4J1

    Brian K. Hall

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  1. Brian K. Hall
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Editors and Affiliations

  1. University College London, London, England

    Ruth Bellairs

  2. University of Glasgow, Glasgow, Scotland

    Donald A. Ede

  3. University of Pennsylvania, Philadelphia, Pennsylvania, USA

    James W. Lash

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Hall, B.K. (1986). Initiation of Chondrogenesis from Somitic, Limb and Craniofacial Mesenchyme: Search for a Common Mechanism. In: Bellairs, R., Ede, D.A., Lash, J.W. (eds) Somites in Developing Embryos. NATO ASI Series, vol 118. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2013-3_20

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