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Processing the Primary Transcripts

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The Gene

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Abstract

Aside from promoters, ancillary sites, terminators, and other features involved in transcription, the mature gene structure includes signals needed for processing of the RNA copy. Indeed, there are many devices encoded into its sequence that act secondarily even after translation is completed. Among these are the clues that afford direction to cleaving enzymes, including the proteases that split transit peptides from diplomorphic gene products or release the ultimate proteins when a cryptomorphic form is to be activated. Although the amino acids involved in such recognition functions are obviously encoded in the mature coding sector and hence are a fundamental part of the gene structure, here attention is restricted to clues that are active directly in the primary transcript. These prove quite adequate to reveal that the problems associated with promoters and their associates in transcriptional functions continue into the present topic, as they doubtlessly also do with regard to the products resulting from translation—a point that becomes particularly clear in a discussion related to intron removal (Section 12.6.3).

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    Lawrence S. Dillon

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Dillon, L.S. (1987). Processing the Primary Transcripts. In: The Gene. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2007-2_12

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