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Principles of Genetic Toxicology pp 121–153Cite as

Genetic Risk Estimation

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Abstract

The state of the art in risk estimation for genotoxic effects in humans was probably best summarized by Newcombe1:

little is known about the extent of the effect on health which a given increase in mutation rate would cause in man. This is true because of a lack of certainty about the amount of ill health that is maintained in the population by the pressure of recurrent natural mutations. Without such knowledge, the importance of exposures to known mutagens is difficult to assess quantitatively with a view to setting reasonable standards for the protection of the human gene pool.

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  1. Hazleton Laboratories, Kensington, Maryland, USA

    David Brusick

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Brusick, D. (1987). Genetic Risk Estimation. In: Principles of Genetic Toxicology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1980-9_5

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  • DOI: https://doi.org/10.1007/978-1-4899-1980-9_5

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