The Ovarian Granulosa Cell as a Follicle-Stimulating Hormone Target Tissue
The ovarian follicle is the basic functional unit of the ovary, and is comprised of an outer layer of theca cells, separated by a basement membrane from the inner layer of granulosa cells, which in turn surround the oocyte-cumulus cell complex. In response to the pituitary gonadotropins, follicle-stimulating hormone (FSH), luteinizing hormone (LH), and prolactin (PRL), the follicle is able to differentiate with regard to steroidogenesis and hormone receptor induction, as well as to produce a fertilizable ovum and adequate corpus luteum. The key anterior pituitary glycoprotein in the initiation of follicular maturation and granulosa cell differentiation is FSH. During reproductive life, FSH is released in an orchestrated cyclic fashion subject to endocrine control.
KeywordsGranulosa Cell Aromatase Activity Luteinizing Hormone Receptor Culture Granulosa Cell Oral Contraceptive Pill User
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