Biological Activity of Non-GnRH Synthetic Peptide Sequences of the GnRH Precursor
The demonstration of GnRH biosynthesis by tryptic and carboxypeptidase B cleavage of a higher molecular precursor in sheep, pig and rat hypothalamus, and the postulate that pGlu1 is derived from cyclizafion of Gln while the amide of Gly10 is generated from an additional Gly followed by a pair of basic amino acid residues (Millar et al., 1977, 1978, 1981), was recently definitively demonstrated by nucleotide sequencing of human placental cDNA (Seeburg and Adelman, 1984) and human and rat hypothalamic cDNA (Adelman et al., 1986).
KeywordsPituitary Cell Prolactin Secretion GnRH Receptor Gonadotropin Release GnRH mRNA
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