Abstract
The functional significance of amino acid transport in skeletal muscle has been explored by the use of a variety of techniques including work in isolated perfused organs, isolated incubated organs and tissue culture of muscle cells. The results suggest that although there is a wide variety of amino acid transport systems of different characteristics and with different responses to ionic, hormonal and nervous modulation, the amino acid glutamine (transported by system Nm) demonstrates some unusual properties not observed with amino acids transported by other systems. Glutamine is transported at very high rates in skeletal muscle and heart and both the glutamate and glutamine transporter appear to be adaptively regulated by the availability of glutamine. Glutamine appears to be involved in the regulation of a number of important metabolic processes in heart and skeletal muscle (e. g., regulation of the glutathione reduced/oxidised ratio and regulation of protein and glycogen synthesis). Furthermore, glutamine transport appears to interact with systems for regulation of volume control and many of the metabolic features attributable to changes in glutamine concentration appear to be modulated via alteration in cytoskeletal status.
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Ahmed, A., D. L. Maxwell, P. M. Taylor, and M. J. Rennie. Glutamine transport in human skeletal muscle. Am. J. Physiol. 264: 993–1000, 1993.
Ahmed, A., P. M. Taylor, and M. J. Rennie. Characteristics of glutamine transport in sarcolemmal vesicles from rat skeletal muscle. Am. J. Physiol. 259: 284–291, 1990.
Häussinger, D. The role of cellular hydration in the regulation of cell function. Biochem. J. 313: 697–710, 1996. (Abstract)
Hundal, H. S., M. J. Rennie, and P. W. Watt. Characteristics of L-glutamine transport in perfused rat skeletal muscle. J. Physiol. (Lond.) 393: 283–305, 1987.
Hundal, H. S., M. J. Rennie, and P. W. Watt. Characteristics of acidic, basic and neutral amino acid transport in perfused rat hindlimb. J. Physiol. (Lond.) 408: 93–114, 1989.
Low, S. Y., M. J. Rennie, and P. M. Taylor. Modulation of glycogen synthesis in rat skeletal muscle by changes in cell volume. J. Physiol. 495: 299–303, 1996.
Low, S. Y., M. J. Rennie, and P. M. Taylor. Signaling elements involved in amino acid transport responses to altered muscle cell volume. FASEBJ. 11: 1111–1117, 1997.
Low, S. Y., M. J. Rennie, and P. M. Taylor. Involvement of integrin and the cytoskeleton in modulation of skeletal muscle glycogen synthesis by changes in cell volume. FEBS Lett 417: 101–103, 1997.
Low, S. Y., P. M. Taylor, and M. J. Rennie. Responses of glutamine transport in cultured rat muscle to osmotically-induced changes in cell volume. J. Physiol. (Lond.) 492: 877–886, 1996.
Mackenzie, B., A. Ahmed, and M. J. Rennie. Muscle amino acid metabolism and transport. In: Mammalian amino acid transport: mechanism and control, edited by M. S. Kilberg and D. Häussinger. New York: Plenum Publishing, 1992.
MacLennan, P. A., R. A. Brown, and M. J. Rennie. A positive relationship between protein synthetic rate and intracellular glutamine concentration in perfused rat skeletal muscle. FEBS Lett. 215: 187–191, 1987.
MacLennan, P. A., K. Smith, B. Weryk, P. W. Watt, and M. J. Rennie. Inhibition of protein breakdown by glutamine in perfused rat skeletal muscle. FEBS Lett. 237: 133–136, 1988.
Rennie, M. J., A. Ahmed, G. W. A. Thompson, K. Smith, W. M. Bennet, and P. W. Watt. Effects of insulin on amino acid transport and protein synthesis in skeletal muscle. In: edited by K. S. Nair. London: Smith Gordon, 1992, p. 173-180.
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Rennie, M.J., Low, S.Y., Taylor, P.M., Khogali, S.E.O., Yao, PC., Ahmed, A. (1998). Amino Acid Transport during Muscle Contraction and Its Relevance to Exercise. In: Richter, E.A., Kiens, B., Galbo, H., Saltin, B. (eds) Skeletal Muscle Metabolism in Exercise and Diabetes. Advances in Experimental Medicine and Biology, vol 441. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1928-1_27
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DOI: https://doi.org/10.1007/978-1-4899-1928-1_27
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