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Anatomy of Glucose Transporters in Skeletal Muscle

Effects of Insulin and Contractions

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Skeletal Muscle Metabolism in Exercise and Diabetes

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 441))

Abstract

Maintaining blood glucose concentration within strict limits is of fundamental importance for preventing the development of various pathophysiological complications as seen in e. g. diabetes mellitus. In this context, skeletal muscle plays a major role. In the postprandial phase it serves as the primary site for disposal of glucose, which is mainly stored as glycogen. Thus approximately half the amount of carbohydrate ingested during a meal is taken up by skeletal muscle (15, 35). In addition it uses glucose for its own metabolic needs, which can increase dramatically during exercise (33). Major determinants of skeletal muscle glucose uptake include glucose supply (arterial concentration × blood flow), glucose transport capacity of the muscle fiber surface membrane, and intracellular metabolism. In this essay we will focus on the expression and localization of glucose transporter proteins in skeletal muscle, which in turn determines the glucose transport capacity of the muscle fiber surface membrane.

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Author information

Authors and Affiliations

  1. Copenhagen Muscle Research Centre Department of Medical Physiology, The Panum Institute, University of Copenhagen, Denmark

    Thorkil Ploug

  2. Laboratory of Neurobiology, NINDS, National Institutes of Health, Bethesda, Maryland, USA

    Evelyn Ralston

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  1. Thorkil Ploug
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  2. Evelyn Ralston
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Editors and Affiliations

  1. Copenhagen Muscle Research Centre, University of Copenhagen, Copenhagen, Denmark

    Erik A. Richter , Bente Kiens , Henrik Galbo  & Bengt Saltin , ,  & 

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Ploug, T., Ralston, E. (1998). Anatomy of Glucose Transporters in Skeletal Muscle. In: Richter, E.A., Kiens, B., Galbo, H., Saltin, B. (eds) Skeletal Muscle Metabolism in Exercise and Diabetes. Advances in Experimental Medicine and Biology, vol 441. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1928-1_2

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  • DOI: https://doi.org/10.1007/978-1-4899-1928-1_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-1930-4

  • Online ISBN: 978-1-4899-1928-1

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