Abstract
Adipose tissue triacylglycerol (TG) constitutes by far the largest energy store in the body. In order for this TG to be used as a substrate for oxidative metabolism, it has to be exported from adipose tissue and transported to the tissues where it will be used. Following hydrolysis of stored TG, non-esterified fatty acids (NEFA) leave the adipocyte and enter the plasma. Unlike tissues such as skeletal muscle which extract plasma NEFA, in adipose tissue the flow of fatty acids across the cell membrane is bi-directional, outward in times of net fat mobilization such as fasting and exercise, and inward during the postprandial period. Factors regulating NEFA delivery in vivo include hormonal and nervous stimulation of lipolysis, and a variety of factors, local and systemic, which oppose this by suppressing lipolysis. Adipose tissue blood flow (ATBF) is also important. ATBF is increased in states of fat mobilization and fat deposition, although there is evidence that during strenuous exercise the increase in ATBF is not sufficient for export of all the NEFA made available from lipolysis. There are well-documented regional variations in lipolysis. The intra-abdominal depots appear to have the highest rates of TG turnover, the subcutaneous abdominal an intermediate rate, and the gluteal-femoral depots to have relatively sluggish turnover. However, much of the evidence for this derives from studies of isolated adipocytes, and confirmation in vivo is much needed. There are links between abdominal fat deposition and risk of cardiovascular disease which may be mediated through increased fatty acid delivery from abdominal fat depots. The ability of exercise specifically to decrease intra-abdominal fat stores may be yet another health benefit of regular exercise.
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References
Andersson, K., and P. Arner. Cholinoceptor-mediated effects on glycerol output from human adipose tissue using in situ microdialysis. Br J Pharmacol 115: 1155–1162, 1995.
Arner, P. Differences in lipolysis between human subcutaneous and omental adipose tissues. Ann Med 27: 435–438, 1995.
Arner, P. Impact of visceral fat. Int J Obesity 21 Suppl 2: S20, 1997.
Arner, P., E. Kriegholm, P. Engfeldt, and J. Bolinder. Adrenergic regulation of lipolysis in situ at rest and during exercise. J Clin Invest 85: 893–898, 1990.
Bonadonna, R. C., L. C. Groop, K. Zych, M. Shank, and R. A. DeFronzo. Dose-dependent effect of insulin on plasma free fatty acid turnover and oxidation in humans. Am J Physiol 259: E736–E750, 1990.
Bülow, J., and J. Madsen. Adipose tissue blood flow during prolonged, heavy exercise. Pflügers Arch 363: 231–234, 1976.
Bülow, J., J. Madsen, A. Astrup, and N. J. Christensen. Vasoconstrictor effect of high FFA/albumin ratios in adipose tissue in vivo. Acta Physiol Scand 125: 661–667, 1985.
Campbell, P. J., M. G. Carlson, J. O. Hill, and N. Nurjhan. Regulation of free fatty acid metabolism by insulin in humans: role of lipolysis and reesterification. Am J Physiol 263: E1063–E1069, 1992.
Cersosimo, E., F. Danou, M. Persson, and J. M. Miles. Effects of pulsatile delivery of basal growth hormone on lipolysis in humans. Am J Physiol 271: E123–E126, 1996.
Després, J.-P., M.-C. Pouliot, S. Moorjani, A. Nadeau, A. Tremblay, P. J. Lupien, G. Thériault, and C. Bouchard. Loss of abdominal fat and metabolic response to exercise training in obese women. Am J Physiol 261: E159–E167, 1991.
Divertie, G. D., M. D. Jensen, and J. M. Miles. Stimulation of lipolysis in humans by physiological hyper-cortisolemia. Diabetes 40: 1228–32, 1991.
Edens, N. K., R. L. Leibel, and J. Hirsch. Mechanism of free fatty acid re-esterification in human adipocytes in vitro. J Lipid Res 31: 1423–1431, 1990.
Elks, M. L., and V. C. Manganiello. Effects of thyroid hormone on regulation of lipolysis and adenosine 3’,5’-monophosphate metabolism in 3T3-L1 adipocytes. Endocrinology 117: 947–53, 1985.
Frayn, K. N., S. W. Coppack, B. A. Fielding, and S. M. Humphreys. Coordinated regulation of hormone-sensitive lipase and lipoprotein lipase in human adipose tissue in vivo: implications for the control of fat storage and fat mobilization. Adv Enz Reg 35: 163–178, 1995.
Frayn, K. N., B. A. Fielding, S. M. Humphreys, and S. W. Coppack. Nutritional influences on human adipose tissue metabolism. Biochem Soc Transac 24: 422–426, 1996.
Frayn, K. N., B. A. Fielding, J. S. Samra, and L. K. M. Summers. Extracellular metabolic regulation in adipose tissue. In: Physiology, Stress, and Malnutrition, edited by Kinney JM, Tucker HN. Philadelphia: Lip-pincott-Raven, 1997, p. 303-323.
Frayn, K. N., V. Hodgetts, and A. J. Griffiths. Mobilization and clearance of fat in exercising humans studied by regional venous catheterization. In: Biochemistry of Exercise IX, edited by Maughan RJ, Shirreffs SM. Champaign, IL: Human Kinetics, 1996, p. 73-88.
Frayn, K. N., and I. A. Macdonald. Adipose tissue circulation. In: Nervous Control of Blood Vessels, edited by Bennett T, Gardiner SM. Amsterdam: Harwood Academic, 1996, p. 505-539.
Frayn, K. N., J. S. Samra, and L. K. M. Summers. Visceral fat in relation to health: is it a major culprit or simply an innocent bystander? Int J Obesity (letter), in press.
Frayn, K. N., S. Shadid, R. Hamlani, S. M. Humphreys, M. L. Clark, B. A. Fielding, O. Boland, and S. W. Coppack. Regulation of fatty acid movement in human adipose tissue in the postabsorptive-to-postprandial transition. Am J Physiol 266: E308–E317, 1994.
Frayn, K. N., C. M. Williams, and P. Arner. Are increased plasma non-esterified fatty acid concentrations a risk marker for coronary heart disease and other chronic diseases? Clin Sci 90: 243–253, 1996.
Grønlund, B., A. Astrup, P. Bie, and N. J. Christensen. Noradrenaline release in skeletal muscle and in adipose tissue studied by microdialysis. Clin Sci 80: 595–598, 1991.
Hodgetts, V., S. W. Coppack, K. N. Frayn, and T. D. R. Hockaday. Factors controlling fat mobilization from human subcutaneous adipose tissue during exercise. J Appl Physiol 71: 445–451, 1991.
Hoffstedt, J., P. Arner, G. Hellers, and F. Lonnqvist. Variation in adrenergic regulation of lipolysis between omental and subcutaneous adipocytes from obese and non-obese men. J Lipid Res 38: 795–804, 1997.
Jensen, M. D., M. Caruso, V. Heiling, and J. M. Miles. Insulin regulation of lipolysis in nondiabetic and IDDM subjects. Diabetes 38: 1595–1601, 1989.
Kovách, A. G. B., S. Roseli, P. Sándor, E. Koltay, E. Kovách, and N. Tomka. Blood flow, oxygen consumption, and free fatty acid release in subcutaneous adipose tissue during hemorrhagic shock in control and phenoxybenzamine-treated dogs. Circ Res 26: 733–741, 1970.
Kurpad, A., K. Khan, A. G. Calder, S. Coppack, K. Frayn, I. Macdonald, and M. Elia. Effect of noradrenaline on glycerol turnover and lipolysis in the whole body and subcutaneous adipose tissue in humans in vivo. Clin Sci 86: 177–184, 1994.
Langin, D., C. Holm, and M. Lafontan. Adipocyte hormone-sensitive lipase: a major regulator of lipid metabolism. Proc Nutr Soc 55: 93–109, 1996.
Leboeuf, B. Regulation of fatty acid esterification in adipose tissue incubated in vitro. In: Handbook of Physiology Section 5: Adipose Tissue, edited by Renold AE, Cahill GF. Washington DC: American Physiological Society, 1965, p. 385-391.
Macdonald, I. A., T. Bennett, A. M. Brown, R. G. Wilcox, and A. M. Skene. The effects of acute or chronic ingestion of Propranolol or metoprolol on the metabolic and hormonal responses to prolonged, submaximal exercise in hypertensive men. Br J Clin Pharmacol 17: 283–293, 1984.
Moller, N., J. O. L. Jørgensen, O. Schmitz, J. Møller, J. S. Christiansen, K. G. M. M. Alberti, and H. Ørskov. Effects of a growth hormone pulse on total and forearm substrate fluxes in humans. Am J Physiol 258: E86–E91, 1990.
Oppenheimer, J. H., H. L. Schwartz, J. T. Lane, and M. P. Thompson. Functional relationship of thyroid hormone-induced lipogenesis, lipolysis, and thermogenesis in the rat. J Clin Invest 87: 125–32, 1991.
Rebuffé-Scrive, M., B. Anderson, L. Olbe, and P. Björntorp. Metabolism of adipose tissue in intraabdominal depots in severely obese men and women. Metabolism 39: 1021–1025, 1990.
Rebuffé-Scrive, M., B. Andersson, L. Olbe, and P. Björntorp. Metabolism of adipose tisue in intraabdominal depots of nonobese men and women. Metabolism 38: 453–458, 1989.
Rebuffé-Scrive, M., P. Lönnroth, P. Mårin, C. Wesslau, P. Björntorp, and U. Smith. Regional adipose tissue metabolism in men and postmenopausal women. Internat J Obesity 11: 347–355, 1987.
Richelsen, B., S. B. Pedersen, T. Møller-Pedersen, and J. F. Bak. Regional differences in triglyceride breakdown in human adipose tissue: effects of catecholamines, insulin, and Prostaglandin E2. Metabolism 40: 990–996, 1991.
Romijn, J. A., E. F. Coyle, L. S. Sidossis, A. Gastaldelli, J. F. Horowitz, E. Endert, and R. R. Wolfe. Regulation of endogenous fat and carbohydrate metabolism in relation to exercise intensity and duration. Am J Physiol 265: E380–E391, 1993.
Romijn, J. A., E. F. Coyle, L. S. Sidossis, X.-J. Zhang, and R. R. Wolfe. Relationship between fatty acid delivery and fatty acid oxidation during strenuous exercise. J Appl Physiol 79: 1939–1945, 1995.
Samra, J. S., M. L. Clark, S. M. Humphreys, K. N. Frayn, and I. A. Macdonald. The role of growth hormone in regulation of lipolysis in normal subjects after an overnight fast. Proc Nutr Soc 56: 90A, 1997.
Samra, J. S., M. L. Clark, S. M. Humphreys, I. A. Macdonald, D. R. Matthews, and K. N. Frayn. Effects of morning rise in cortisol concentration on regulation of lipolysis in subcutaneous adipose tissue. Am J Physiol 271: E996–E1002, 1996.
Samra, J. S., E. J. Simpson, M. L. Clark, C. D. Forster, S. M. Humphreys, I. A. Macdonald, and K. N. Frayn. Effects of adrenaline infusion on the interstitial environment of subcutaneous adipose tissue as studied by microdialysis. Clin Sci 91: 425–430, 1996.
Samra, J. S., E. J. Simpson, M. L. Clark, C. D. Forster, S. M. Humphreys, I. A. Macdonald, and K. N. Frayn. Effects of epinephrine infusion on adipose tissue: interactions between blood flow and lipid metabolism. Am J Physiol 271: E834–E839, 1996.
Sniderman, A. D., K. Cianflone, and K. Frayn. The pathogenetic role of impaired fatty acid trapping by adipocytes in generating the pleiotropic features of hyperapoB. Diabetologia 40: S152–S154, 1997.
Sniderman, A. D., K. Cianflone, L. K. M. Summers, B. A. Fielding, and K. N. Frayn. The acylation-stimulating protein pathway and regulation of postprandial metabolism. Proc Nutr Soc 56: 703–712, 1997.
Stoner, H. B., K. N. Frayn, R. N. Barton, C. J. Threlfall, and R. A. Little. The relationships between plasma substrates and hormones and the severity of injury in 277 recently injured patients. Clin Sci 56: 563–573, 1979.
Tremblay, A., and B. Buemann. Exercise-training, macronutrient balance and body weight control. Int J Obesity 19: 79–86, 1995.
Vikman, H. L., S. Ranta, T. Kiviluoto, and J. J. Ohisalo. Different metabolic regulation by adenosine in omental and subcutaneous adipose tissue. Acta Physiol Scand 142: 405–410, 1991.
Wijnen, J. A. G., M. A. van Baak, C. de Haan, H. A. J. Struijker Boudier, F. S. Tan, and L. M. A. B. Van Bortel. Beta-blockade and lipolysis during endurance exercise. Eur J Clin Pharmacol 45: 101–105, 1993.
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Frayn, K.N. (1998). Regulation of Fatty Acid Delivery in Vivo. In: Richter, E.A., Kiens, B., Galbo, H., Saltin, B. (eds) Skeletal Muscle Metabolism in Exercise and Diabetes. Advances in Experimental Medicine and Biology, vol 441. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1928-1_16
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DOI: https://doi.org/10.1007/978-1-4899-1928-1_16
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