Abstract
Insulin sensitivity relates to the fatty acid composition of the skeletal muscle phos-pholipids and the intramuscular triglyceride content. The fatty acid composition of the phospholipids—but not of the triglycerides—in the muscles are influenced by regular physical activity of low-moderate intensity. An increased degree of unsaturation of the cell membranes after training may hypothetically contribute to the improvement of insulin sensitivity. Different ways of reducing the supply of lipids in the muscles may possibly cause similar changes of the fatty acid composition of the cell membranes. Further studies are needed to explore the relationships between changes of the skeletal muscle lipid composition during physical activity, the interaction with dietary fat intake, and changes of insulin sensitivity and development of related metabolic disorders.
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References
Ayre KJ and AJ Hulbert. Dietary fatty acid profile influences the composition of skeletal muscle phos-pholipids in rats. J. Nutr. 126: 653–662, 1996.
Borkman M, LH Storlien, DA Pan, AB Jenkins, DJ Chisholm and LB Campbell. The relationship between insulin sensitivity and the fatty acid composition of skeletal-muscle phospholipids. N. Engl. J. Med. 328: 238–244., 1993.
Ginsberg BH, TJ Brown, I Simonand M Spector. Effect of membrane lipid environment on the properties of insulin receptors. Diabetes. 30: 773–780, 1981.
Glatz FCG, AEMF Soffers and MB Katan. Fatty acid composition of serum cholesteryl esters and erythrocyte membranes as indicators of linoleic acid intake in man. Am. J. Clin. Nutr. 49: 269–276, 1989.
Gordon T, A Kagan, M Garcia-Palmieri, WB Kannel, WJ Zukel, J Tillotson, P Sorlie and M Hjortland. Diet and its relation to coronary heart disease and death in three populations. Circulation. 63: 500–515, 1981.
Grunfeld C, KI Baird and CR Kahn. Maintenance of 3T3-L1 cells in culture media containing saturated fatty acids decreases insulin binding and insulin action. Biochem. Biophys. Res. Commun. 103: 219–226, 1981.
Hurley BF, PM Nemeth, WH Martin III, JM Hagberg, GP Dalsky and JO Hollosz. Muscle triglyceride utilization during exercise. J. Appl. Physiol. 60: 562–567, 1986.
Kushi L, RA Lew, FJ Stare, CR Ellison, M El Lozy, G Bourke, L Daly, I Graham, N Hickey, R Mulcahy and J Kevaney. Diet and 20-year mortality from coronary heart disease. The Ireland-Boston Diet-Heart Study. N. Engl. J. Med. 312: 811–818, 1985.
Leyton J, PJ Drury and MA Crawford. In vivo incorporation of labeled fatty acids in rat liver lipids after oral administration. Lipids. 22: 553–558, 1987.
London SJ, FM Sacks, J Caesar, MJ Stampfer, E Siguel and WC Willet. Fatty acid composition of subcutaneous adipose tissue and diet in postmenopausal US women. Am. J. Clin. Nutr. 54: 340–345, 1991.
Marshall JA, RF Hamman and J Baxter. High-fat, low-carbohydrate diet and the etiology of non-insulin-dependent diabetes mellitus: The San Luis Valley Diabetes Study. Am. J. Epidemiol. 134: 590–603, 1991.
Mayer EJ, B Newman, CP Quesenberry and JV Selby. Usual dietary fat intake and insulin concentrations in healthy women twins. Diabetes Care. 16: 1459–69, 1993.
Mayer-Davis EJ, JH Monaco, HM Hoen, S Carmichael, MZ Vitolins, MJ Rewers, SM Haffner, MF Ayad, RN Bergman and AJ Karter, for the IRAS investigators. Dietary fat and insulin sensitivity in a triethnic population: the role of obesity. The Insulin Resistance Atherosclerosis Study (IRAS). Am. J. Clin. Nutr. 65: 79–87, 1997.
Melin T, C Qi, G Bengtsson-Olivecrona, B Akesson and Å Nilsson. Hydrolysis of chylomicron polyenoic fatty acid esters with lipoprotein lipase and hepatic lipase. Biochim. Biophys. Acta. 1075: 259–266, 1991.
Nikkari T, P Lukkainen, P Pietinen and P Puska. Fatty acid composition of serum lipid fractions in relation to gender and quality of dietary fat. Annals of Medicine. 27: 491–498, 1995.
Nilsson Å, B Landin, E Jensen and B Åkesson. Absorption and lymphatic transport of exogenous and endogenous arachidonic acid and linoleic acid in the rat. Am. J. Physiol. 252: G817–G824, 1987.
Öhrvall M, S Tengblads, B Vessbyb. Tocopherol concentrations in adipose tissue and relationships to tocopherol concentrations and fatty acid composition in serum. Europ. J. Clin. Nutr. 48: 212–218, 1994.
Pan DA, S Lillioja, AD Kriketos, MR Milne, LA Baur, C Bogardus, AB Jenkins and LH Storlien. Skeletal muscle triglyceride levels are inversely related to insulin action. Diabetes. 46: 983–988, 1997.
Romijn JA, EF Coyle, LS Sidossis, A Gastaldelli, JF Horowitz, E Endert and RR Wolfe. Regulation of endogenous fat and carbohydrate metabolism in relation to exercise intensity and duration. Am. J. Physiol. 265 (Endocrinol Metab 28): E380-E391, 1993.
Andersson A, A. Sjödin, R Olsson and B Vessby. Effects of physical exercise on phospholipid fatty acid composition in skeletal muscle. Am. J. Physiol. 274 (Endocrinol. Metab. 37): E432-E438, 1998.
van Staveren WA, P Deurenberg, MB Katan, J Durema, LCPGM de Groot and MDAF Hoffmans. Validity of the fatty acid composition of subcutaneous adipose tissue micro bioipsies as an estimate of the diet of separate individuals. Am. J. Epidemiol. 123: 455–463, 1986.
Storlien LH, EW Kraegen, DJ Chisholm, GL Ford, DG Bruce and WS Pascoe. Fish oil prevents insulin resistance induced by high-fat feeding in rats. Science. 237: 885–888, 1987.
Storlien LH, AB Jenkins, DJ Chisholm, WS Pascoe, S Khouri and EW Kraegen. Influence of dietary fat composition on development of insulin resistance in rats. Relation to muscle triglycerides and w-3 fatty acids in muscle phospholipid. Diabetes. 40: 280–289, 1991.
Storlien LH, ND Oakes, DA Pan, M Kusunoki and AB Jenkins. Syndromes of insulin resistance in the rat. Inducement by diet and amelioration with benflurex. Diabetes 42: 457–462, 1993.
Storlien LH, DA Pan, AD Kriketos and LA Baur. High fat diet-induced insulin resistance. Lessons and implications from animal studies. Ann. NY Acad. Sci. 683: 82–90, 1993.
Storlien LH, LA Baur, AD Kriketos, DA Pan, GJ Cooney, AB Jenkins, GD Calvert and LV Campbell. Dietary fats and insulin action. Diabetologia. 39: 621–631, 1996.
Storlien LH. Effects of benflurex on membrane lipid unsaturation: A beneficial effect for membrane fluidity and insulin action. 11th Int Symp on Atherosclerosis, Paris, October 1997 (abstr).
Vessby B, S Tengblad, and H Lithell. The insulin sensitivity is related to the fatty acid composition of the serum lipids and of the skeletal muscle phospholipids in 70 year old men. Diabetologia. 37: 1044–1050, 1994.
Vessby B. Current Opinion in Lipidology 6: 3–7, 1995.
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Vessby, B., Andersson, A., Sjödin, A. (1998). Training Induced Changes in the Fatty Acid Composition of Skeletal Muscle Lipids. In: Richter, E.A., Kiens, B., Galbo, H., Saltin, B. (eds) Skeletal Muscle Metabolism in Exercise and Diabetes. Advances in Experimental Medicine and Biology, vol 441. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1928-1_13
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DOI: https://doi.org/10.1007/978-1-4899-1928-1_13
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