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Prions and Brain Diseases in Animals and Humans pp 177–185Cite as

Polyene Antibiotics in Experimental Transmissible Subacute Spongiform Encephalopathies

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Part of the book series: NATO ASI Series ((NSSA,volume 295))

Abstract

Transmissible subacute spongiform encephalopathies (TSSE) form a group of fatal neurodegenerative diseases which include Creutzfeldt-Jakob disease in humans, scrapie in sheep and goats and bovine spongiform encephalopathy (BSE) in cattle. They are characterized by a long incubation period which precedes clinical symptoms related to the central nervous system (CNS) degeneration. In experimental models, a modified proteinase-resistant form (PrPres) of a host-encoded protein (PrP) accumulates in the brain proportionally to infectivity1,2. A transcriptional overexpression of glial fibrillary acidic protein (GFAP), a specific marker of astrocytes, has also been observed3,4,5.

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Author information

Authors and Affiliations

  1. Service de Neurovirologie, DRM/DSV/SSA Commissariat à l’Energie Atomique, B.P. 6, 92 265, Fontenay aux Roses Cedex, France

    Vincent Beringue, Rémi Demaimay, Karim T. Adjou, Séverine Demart, François Lamoury, Corinne I. Lasmézas, Jean-Philippe Deslys & Dominique Dormont

  2. Laboratoire d’Immunodifférenciation Institut Jacques Monod, Université de Paris VII, Paris, France

    Michel Seman

Authors
  1. Vincent Beringue
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  2. Rémi Demaimay
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  3. Karim T. Adjou
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  4. Séverine Demart
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  5. François Lamoury
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  6. Michel Seman
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  7. Corinne I. Lasmézas
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  8. Jean-Philippe Deslys
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  9. Dominique Dormont
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  1. CH-1296, Coppet, Switzerland

    Douglas R. O. Morrison

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Beringue, V. et al. (1998). Polyene Antibiotics in Experimental Transmissible Subacute Spongiform Encephalopathies. In: Morrison, D.R.O. (eds) Prions and Brain Diseases in Animals and Humans. NATO ASI Series, vol 295. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1896-3_18

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  • DOI: https://doi.org/10.1007/978-1-4899-1896-3_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-1898-7

  • Online ISBN: 978-1-4899-1896-3

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