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Monoamine Oxidases

  • Chapter
Handbook of Neurochemistry

Abstract

Mitochondrial monoamine oxidase (MAO) (amine: oxygen oxidoreductase, deaminating, flavin-containing; E.C. 1.4.3.4) does not display profound substrate or inhibitor specificity. Included in its substrates are the amine neurotransmitters epinephrine (E), norepinephrine (NE), dopamine (DA), and serotonin (5-HT) and other amines with false neurotransmitter or sympathomimetic properties, e.g., octopamine, tyramine, β-phenylethylamine (PEA), and tryptamine. Inactivation of MAO in vivo with irreversible MAO inhibitors leads to elevation of brain levels of these amines with a concomitant decrease in levels of their deaminated metabolites. Animal behavioral studies have shown that inhibition of MAO can result in overt behavioral changes. Thus, a regulatory role has been assigned to MAO in the brain.

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  1. Rappaport Family Medical Research Institute, Technion, Haifa, Israel

    J. P. M. Finberg & M. B. H. Youdim

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  1. J. P. M. Finberg
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  1. Center for Neurochemistry, Rockland Research Institute, Wards Island, New York, New York, 10035, USA

    Abel Lajtha

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Finberg, J.P.M., Youdim, M.B.H. (1983). Monoamine Oxidases. In: Lajtha, A. (eds) Handbook of Neurochemistry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1881-9_12

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