Abstract
Pyrogens are classified into two groups, exogenous and endogenous. Exogenous pyrogens originating in the cell wall of gram-negative bacteria have the strongest pyrogenicity (Nowotny, 1969), and for them synonyms such as endotoxins, lipopolysaccharides (LPS), and O-antigens are used. If a pharmacologically active substance is contaminated with pyrogens, its intravenous administration produces transient fever in homoiothermic animals. Therefore, it is necessary to remove any pyrogen present in medicines or drugs for intravenous administration.
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Tosa, T., Sato, T., Watanabe, T., Minobe, S. (1993). Affinity Chromatographic Removal of Pyrogens. In: Ngo, T.T. (eds) Molecular Interactions in Bioseparations. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1872-7_21
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DOI: https://doi.org/10.1007/978-1-4899-1872-7_21
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