Abstract
Intestinal rings and isolated intestinal mucosal cells have been employed for over 25 years in the examination of biologic problems in the fields of nutrition (Del Castillo and Muniz, 1991; Fleisher et al., 1989; Gore and Hoinard, 1993; Shaw et al., 1983; Westergaard and Dietschy, 1976), pharmaceutics (Kajii et al., 1985; Meadows and Dressman, 1990; Osiecka et al., 1987; Porter et al., 1985; Tsuji et al., 1986, 1987), cell biology (Weiser, 1973a, b), and metabolism and biochemistry (Grafstrom et al., 1979; Kelley and Chen, 1985; Koster et al., 1984; Sepulveda et al., 1982; Stern, 1966). Of particular interest here is the utility of these relatively simple in vitro models for characterizing, within defined limits, the absorptive and metabolic properties of intestinal tissue.
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Fix, J.A. (1996). Intestinal Rings and Isolated Intestinal Mucosal Cells. In: Borchardt, R.T., Smith, P.L., Wilson, G. (eds) Models for Assessing Drug Absorption and Metabolism. Pharmaceutical Biotechnology, vol 8. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1863-5_4
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DOI: https://doi.org/10.1007/978-1-4899-1863-5_4
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