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Models for Assessing Drug Absorption and Metabolism pp 387–407Cite as

Isolated Perfused Porcine Skin Flap Systems

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Part of the book series: Pharmaceutical Biotechnology ((PBIO,volume 8))

Abstract

The ultimate goal of an in vitro model system is to predict the behavior of the drug in the in vivo setting. Most in vitro skin models used to assess the percutaneous absorption or transdermal delivery of topically applied drugs are designed around the assumption that the stratum corneum and/or epidermis is the principal barrier to compound penetration through skin. Thus, all such models were usually avascular and, until recently, nonviable preparations. However, in vivo, this stratum corneum and living epidermal barrier resides on a well-vascularized and metabolically active dermal substrate offering ample biological targets for specific types of drugs. Drugs may be vasoactive and modulate the cutaneous microcirculation; they may serve as substrates of epidermal and dermal drug-metabolizing enzymes, or they may activate cytokine and/or other modulator receptors which result in changes in epidermal, dermal, or endothelial cell function. Therefore, the anatomical and physiological complexity of human skin is significantly greater than that modeled in existing in vitro systems, which thus do not afford the possibility of detecting these potential biologically relevant events.

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Author information

Authors and Affiliations

  1. Cutaneous Pharmacology and Toxicology Center, North Carolina State University, Raleigh, North Carolina, 27606, USA

    Jim E. Riviere

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  1. Jim E. Riviere
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Editor information

Editors and Affiliations

  1. The University of Kansas, Lawrence, Kansas, USA

    Ronald T. Borchardt

  2. SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania, USA

    Philip L. Smith

  3. Tacora Corporation, Seattle, Washington, USA

    Glynn Wilson

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© 1996 Springer Science+Business Media New York

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Riviere, J.E. (1996). Isolated Perfused Porcine Skin Flap Systems. In: Borchardt, R.T., Smith, P.L., Wilson, G. (eds) Models for Assessing Drug Absorption and Metabolism. Pharmaceutical Biotechnology, vol 8. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1863-5_21

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  • DOI: https://doi.org/10.1007/978-1-4899-1863-5_21

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-1865-9

  • Online ISBN: 978-1-4899-1863-5

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